| Tianyin Ma,Zhang Chen,Yibo Chai,Xiangdong Gongye,Peng Xia,Chenming Qu,Ming Tian,Yufeng Yuan. Research progress on immunotherapy for cholangiocarcinoma targeting the tumor immune microenvironment. Oncol Transl Med, 2023, 9: 49-55. |
| 针对肿瘤免疫微环境的胆管癌免疫治疗的研究进展 |
| Research progress on immunotherapy for cholangiocarcinoma targeting the tumor immune microenvironment |
| Received:April 18, 2023 Revised:May 05, 2023 |
| DOI：10.1007/s10330-023-0642-2 |
| 中文关键词: 胆管癌；肿瘤免疫微环境；肿瘤相关巨噬细胞；肿瘤浸润淋巴细胞；过继性T细胞转移；免疫检查点抑制剂；免疫疗法 |
| 英文关键词: Cholangiocarcinoma; Tumor Immune Microenvironment; Tumor-Associated Macrophages; Tumor-Infiltrating Lymphocytes; Adoptive T-cell Transfer; Immune Checkpoint Inhibitors; Immunotherapy |
| 基金项目:我们的工作得到了湖北省卫计委医学科研基金（WJ2021M255）、武汉大学中南医院癌症研究与转化平台项目（ZLYNXM202004）、湖北省重点研发计划（2021BCA114）、武汉大学中南医院医学科技创新平台研究基金（PTXM2021022）、武汉大学中南医院优秀博士（博士后）项目（批准号：ZNYB2021021）的支持。 |
| Author Name | Affiliation | E-mail | | Tianyin Ma | Zhongnan Hospital of Wuhan University | martintwina@outlook.com | | Zhang Chen | Zhongnan Hospital of Wuhan University | | | Yibo Chai | Zhongnan Hospital of Wuhan University | | | Xiangdong Gongye | Zhongnan Hospital of Wuhan University | | | Peng Xia | Zhongnan Hospital of Wuhan University | | | Chenming Qu | Zhongnan Hospital of Wuhan University | | | Ming Tian | Zhongnan Hospital of Wuhan University | | | Yufeng Yuan* | Zhongnan Hospital of Wuhan University | yuanyf1971@whu.edu.cn |
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| 中文摘要: |
| 胆管癌（CCA）是第二种最常见的肝胆癌，其发病率近年来显著增加。由于诊断和治疗方案有限，CCA的预后效果不佳。肿瘤免疫微环境（TIME）由免疫细胞、细胞因子和趋化因子组成，在癌症进展和逃避免疫监视和治疗反应方面起着重要作用。针对TIME的免疫治疗策略提供了识别和根除CCA的潜力。本综述讨论了CCA中TIME的细胞和分子成分以及针对TIME的免疫治疗策略。 |
| 英文摘要: |
| Cholangiocarcinoma (CCA) is the second most common hepatobiliary cancer and its incidence has increased significantly in recent years. CCA has poor prognostic outcomes due to limited diagnosis and treatment options. The tumor immune microenvironment (TIME), comprising immune cells, cytokines, and chemokines, plays a significant role in cancer progression and evasion from immune surveillance and therapeutic responses. Immunotherapeutic strategies targeting TIME offer the potential for recognition and eradication of CCA. This review discusses the cellular and molecular components of TIME in CCA and immunotherapeutic strategies targeting TIME. |
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