| Tianyin Ma,Zhang Chen,Yibo Chai,Xiangdong Gongye,Peng Xia,Chenming Qu,Ming Tian,Yufeng Yuan. Research progress on immunotherapy for cholangiocarcinoma targeting the tumor immune microenvironment. Oncol Transl Med, 2023, 9: 49-55. |
| Research progress on immunotherapy for cholangiocarcinoma targeting the tumor immune microenvironment |
| Received:April 18, 2023 Revised:May 05, 2023 |
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| KeyWord:Cholangiocarcinoma; Tumor Immune Microenvironment; Tumor-Associated Macrophages; Tumor-Infiltrating Lymphocytes; Adoptive T-cell Transfer; Immune Checkpoint Inhibitors; Immunotherapy |
| Author Name | Affiliation | E-mail | | Tianyin Ma | Zhongnan Hospital of Wuhan University | martintwina@outlook.com | | Zhang Chen | Zhongnan Hospital of Wuhan University | | | Yibo Chai | Zhongnan Hospital of Wuhan University | | | Xiangdong Gongye | Zhongnan Hospital of Wuhan University | | | Peng Xia | Zhongnan Hospital of Wuhan University | | | Chenming Qu | Zhongnan Hospital of Wuhan University | | | Ming Tian | Zhongnan Hospital of Wuhan University | | | Yufeng Yuan | Zhongnan Hospital of Wuhan University | yuanyf1971@whu.edu.cn |
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| Abstract: |
| Cholangiocarcinoma (CCA) is the second most common hepatobiliary cancer and its incidence has increased significantly in recent years. CCA has poor prognostic outcomes due to limited diagnosis and treatment options. The tumor immune microenvironment (TIME), comprising immune cells, cytokines, and chemokines, plays a significant role in cancer progression and evasion from immune surveillance and therapeutic responses. Immunotherapeutic strategies targeting TIME offer the potential for recognition and eradication of CCA. This review discusses the cellular and molecular components of TIME in CCA and immunotherapeutic strategies targeting TIME. |
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