| Zhitang Guo,Ming Zhang,Ang Liu,Zhihong Zhang,Kejia Li,Jiayun Ge. Successful surgical resection of large hepatocellular carcinoma with portal vein tumor thrombus after conversion therapy with mFOLFOX-HAIC combined with donafenib and sintilimab: two case reports and a literature review. Oncol Transl Med, 2023, 9: 66-72. |
| mFOLFOX-HAIC联合多纳非尼和信迪利单抗转化治疗大肝癌合并门静脉癌栓后成功手术切除：2例病例报告并文献复习 |
| Successful surgical resection of large hepatocellular carcinoma with portal vein tumor thrombus after conversion therapy with mFOLFOX-HAIC combined with donafenib and sintilimab: two case reports and a literature review |
| Received:April 07, 2023 Revised:April 27, 2023 |
| DOI：10.1007/s10330-023-0639-9 |
| 中文关键词: 肝细胞癌；门静脉癌栓；免疫治疗；靶向治疗；mFOLFOX-HAIC |
| 英文关键词: hepatocellular carcinoma; portal vein tumor thrombus; immunotherapy; targeted therapy; mFOLFOX-HAIC |
| 基金项目:基金资助：昆明医科大学临床研究项目（No. ynIIT20211013）和昆明医科大学联合专项基金项目（No. 202201AY070001-105）. |
| Author Name | Affiliation | E-mail | | Zhitang Guo | Second Affliated Hospital, Kunming Medical University | xiaoguozhitang@163.com | | Ming Zhang | Yunnan Maternl and Child Health Care Hospital | | | Ang Liu | Shiping County People''s Hospital | | | Zhihong Zhang | Second Affliated Hospital, Kunming Medical University | | | Kejia Li | Third Affiliated Hospital, Yunnan University of Traditional Chinese Medicine | | | Jiayun Ge* | Third Affiliated Hospital, Yunnan University of Traditional Chinese Medicine | gejy520@163.com |
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| 中文摘要: |
| 目的 评价mFOLFOX-HAIC方案联合多纳非尼和信迪利单抗转化治疗后手术切除治疗大肝癌合并门静脉癌栓的临床疗效。
方法 回顾性收集昆明医科大学第二附属医院收治的2例大肝癌患者的临床资料。2例患者均接受mFOLFOX-HAIC联合多纳非尼和信迪利单抗转化治疗后行肝切除术。记录患者的临床资料并评价临床疗效。
结果1例患者肿瘤直径14.5*11.1cm，伴门静脉右支癌栓，另1例肿瘤直径12.1*8.3cm，伴门静脉、肝静脉癌栓，2例患者转化治疗前均为IIIa期，转化治疗后均降为Ib期，随后分别行开腹和腹腔镜右半肝切除术。
结论mFOLFOX-HAIC方案联合多纳非尼和信迪利单抗短期高强度转化治疗大肝癌伴门静脉癌栓是一种可行、有效的治疗方法。 |
| 英文摘要: |
| The aim of our study was to evaluate the clinical efficacy of mFOLFOX-HAIC combined with donafenib and
sintilimab conversion therapy followed by surgical resection of large hepatocellular carcinoma with portal
vein tumor thrombus (PVTT). The clinical data of two patients with large hepatocellular carcinoma who were
admitted to the Second Affiliated Hospital of Kunming Medical University were retrospectively collected.
Both patients received mFOLFOX-HAIC combined with donafenib and sintilimab conversion therapy,
followed by hepatectomy. Clinical data were reported, and clinical efficacy was evaluated. One patient had
a 14.5 × 11.1 cm tumor with a tumor thrombus in the right portal vein. The other patient had a 12.1 × 8.3
cm tumor with portal and hepatic vein tumor thrombi. Both patients had CNLC stage IIIa prior to conversion
therapy, which was reduced to stage Ib after conversion therapy. Subsequently, the patient underwent open
and laparoscopic right hemihepatectomies. Short-term high-intensity conversion therapy with mFOLFOXHAIC
combined with donafenib and sintilimab is a feasible and effective treatment for patients with large
hepatocellular carcinoma with PVTT. |
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