| Zhitang Guo,Ming Zhang,Ang Liu,Zhihong Zhang,Kejia Li,Jiayun Ge. Successful surgical resection of large hepatocellular carcinoma with portal vein tumor thrombus after conversion therapy with mFOLFOX-HAIC combined with donafenib and sintilimab: two case reports and a literature review. Oncol Transl Med, 2023, 9: 66-72. |
| Successful surgical resection of large hepatocellular carcinoma with portal vein tumor thrombus after conversion therapy with mFOLFOX-HAIC combined with donafenib and sintilimab: two case reports and a literature review |
| Received:April 07, 2023 Revised:April 27, 2023 |
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| KeyWord:hepatocellular carcinoma; portal vein tumor thrombus; immunotherapy; targeted therapy; mFOLFOX-HAIC |
| Author Name | Affiliation | E-mail | | Zhitang Guo | Second Affliated Hospital, Kunming Medical University | xiaoguozhitang@163.com | | Ming Zhang | Yunnan Maternl and Child Health Care Hospital | | | Ang Liu | Shiping County People''s Hospital | | | Zhihong Zhang | Second Affliated Hospital, Kunming Medical University | | | Kejia Li | Third Affiliated Hospital, Yunnan University of Traditional Chinese Medicine | | | Jiayun Ge | Third Affiliated Hospital, Yunnan University of Traditional Chinese Medicine | gejy520@163.com |
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| Abstract: |
| The aim of our study was to evaluate the clinical efficacy of mFOLFOX-HAIC combined with donafenib and
sintilimab conversion therapy followed by surgical resection of large hepatocellular carcinoma with portal
vein tumor thrombus (PVTT). The clinical data of two patients with large hepatocellular carcinoma who were
admitted to the Second Affiliated Hospital of Kunming Medical University were retrospectively collected.
Both patients received mFOLFOX-HAIC combined with donafenib and sintilimab conversion therapy,
followed by hepatectomy. Clinical data were reported, and clinical efficacy was evaluated. One patient had
a 14.5 × 11.1 cm tumor with a tumor thrombus in the right portal vein. The other patient had a 12.1 × 8.3
cm tumor with portal and hepatic vein tumor thrombi. Both patients had CNLC stage IIIa prior to conversion
therapy, which was reduced to stage Ib after conversion therapy. Subsequently, the patient underwent open
and laparoscopic right hemihepatectomies. Short-term high-intensity conversion therapy with mFOLFOXHAIC
combined with donafenib and sintilimab is a feasible and effective treatment for patients with large
hepatocellular carcinoma with PVTT. |
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