| Zhijie Fan,Motuma Yigezu Daba,Xiaoling Yan,Xianglin Yuan. Role of miRNA-21 in radiation-induced heart disease. Oncol Transl Med, 2023, 9: 56-65. |
| miRNA-21在放射性心脏损伤中的作用 |
| Role of miRNA-21 in radiation-induced heart disease |
| Received:February 03, 2023 Revised:April 23, 2023 |
| DOI：10.1007/s10330-023-0625-5 |
| 中文关键词: microRNA-21（miRNA-21），放射性心脏损伤（RIHD），生物标志物，靶向治疗，纤维化 |
| 英文关键词: microRNA-21 (miRNA-21); radiation-induced heart disease (RIHD); biomarkers; targeted therapy; fibrosis |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Zhijie Fan | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China | ZJFan_000@163.com | | Motuma Yigezu Daba | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China | | | Xiaoling Yan | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China | | | Xianglin Yuan* | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China | yuanxianglin@hust.edu.cn |
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| 中文摘要: |
| 放射性心脏损伤（RIHD）是胸部放射治疗（RT）的一种潜在的致命性临床并发症。RIHD的临床表现包括心肌病、心包炎、冠状动脉动脉粥样硬化、瓣膜病和传导缺陷，这些情况会损害患者放疗后的长期健康状况，并限制了可使用的有效杀死肿瘤细胞所需的放疗剂量和强度。其潜在的细胞和分子机制在很大程度上仍不清楚。MicroRNA（miRNA）是高度保守的非编码单链小分子RNA，其调节了基因表达并参与到细胞的增殖、凋亡、分化和疾病发展的过程。MicroRNA-21（miRNA-21）是近年来在肿瘤和心血管疾病领域研究最深入的miRNA之一。大量证据表明miRNA-21在RIHD中起重要作用。本文回顾了miRNA-21在心血管系统中的来源和功能，以及miRNA-21在RIHD发病机制中的作用。此外，还讨论了miRNA-21作为预测和治疗RIHD的新靶点的潜在作用。 |
| 英文摘要: |
| Radiation-induced heart disease (RIHD) is a potentially fatal clinical complication of chest radiotherapy
(RT). RIHD is detrimental to the long-term health of post-RT survivors and limits the dose and intensity of
RT required to effectively kill tumor cells. However, the cellular and molecular mechanisms underlying these
effects remain largely unknown. MicroRNAs (miRNAs) are highly conserved, non-coding, single-stranded,
small molecular RNAs that regulate gene expression and participate in cellular proliferation, apoptosis,
differentiation, and disease development. MicroRNA-21 (miRNA-21) has become one of the most
intensively studied miRNAs in the fields of cancer and cardiovascular disease in recent years. miRNA-21
plays an important role in RIHD progression. This article reviews the origin and function of miRNA-21 in the
cardiovascular system and its role in RIHD pathogenesis. In addition, the potential role of miRNA-21 as a
new target for predicting and treating RIHD is also discussed. |
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