| Zhijie Fan,Motuma Yigezu Daba,Xiaoling Yan,Xianglin Yuan. Role of miRNA-21 in radiation-induced heart disease. Oncol Transl Med, 2023, 9: 56-65. |
| Role of miRNA-21 in radiation-induced heart disease |
| Received:February 03, 2023 Revised:April 23, 2023 |
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| KeyWord:microRNA-21 (miRNA-21); radiation-induced heart disease (RIHD); biomarkers; targeted therapy; fibrosis |
| Author Name | Affiliation | E-mail | | Zhijie Fan | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China | ZJFan_000@163.com | | Motuma Yigezu Daba | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China | | | Xiaoling Yan | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China | | | Xianglin Yuan | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China | yuanxianglin@hust.edu.cn |
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| Abstract: |
| Radiation-induced heart disease (RIHD) is a potentially fatal clinical complication of chest radiotherapy
(RT). RIHD is detrimental to the long-term health of post-RT survivors and limits the dose and intensity of
RT required to effectively kill tumor cells. However, the cellular and molecular mechanisms underlying these
effects remain largely unknown. MicroRNAs (miRNAs) are highly conserved, non-coding, single-stranded,
small molecular RNAs that regulate gene expression and participate in cellular proliferation, apoptosis,
differentiation, and disease development. MicroRNA-21 (miRNA-21) has become one of the most
intensively studied miRNAs in the fields of cancer and cardiovascular disease in recent years. miRNA-21
plays an important role in RIHD progression. This article reviews the origin and function of miRNA-21 in the
cardiovascular system and its role in RIHD pathogenesis. In addition, the potential role of miRNA-21 as a
new target for predicting and treating RIHD is also discussed. |
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