| Ze Ouyang,Weili Tao,Shiying Yu,Man Zou. Advances in pharmacotherapies in cancer-related cachexia. Oncol Transl Med, 2023, 9: 15-21. |
| 癌症恶病质药物治疗方法进展 |
| Advances in pharmacotherapies in cancer-related cachexia |
| Received:November 04, 2022 Revised:February 27, 2023 |
| DOI：10.1007/s10330-022-0611-1 |
| 中文关键词: 癌症，恶病质，肌肉丢失，机制，药物治疗 |
| 英文关键词: cancer; cachexia; muscle wasting; mechanism; drug therapy |
| 基金项目:国家自然科学基金(No.82003234) |
| Author Name | Affiliation | E-mail | | Ze Ouyang | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | ouyz20@163.com | | Weili Tao | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Shiying Yu | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Man Zou* | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | skyfountain@163.com |
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| 中文摘要: |
| 恶病质在癌症患者中发病率高，严重影响患者积极抗肿瘤治疗、生存质量和生存时间，影响了50-80%晚期癌症患者，现有的治疗手段对恶病质改善有限，亟需寻找新的治疗方法来改善患者的恶病质情况。近几年，关于癌症相关恶病质肌肉萎缩和体重减轻的机制和治疗药物有了新的发展，本文就恶病质最新的治疗研究进展进行系统综述。 |
| 英文摘要: |
| Cancer-related cachexia is highly prevalent in patients with advanced cancer, affecting approximately 50%–
80% of patients and seriously interfering with active therapy, quality of life, and survival time. There are
currently no effective treatments for cachexia. Therefore, new therapeutic strategies are required. In recent
years, advances in understanding the mechanisms underlying cachexia have been made, and new drugs
have been developed to combat cachexia muscle wasting and weight loss due to cancer. In this systematic
review, we discuss these novel targets and drug treatments. |
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