Daijun Xing,Fuman Wang,Min Qi,Xiaokun Wang,Xu Zhu,Yufeng Cao,Zhengtong Zhao,Gaoyang Lin. EZH2 is a biomarker associated with lung cancer diagnosis and immune infiltrates without prognostic specificity: a study based on the cancer genome atlas data. Oncol Transl Med, 2023, 9: 99-114.
EZH2 is a biomarker associated with lung cancer diagnosis and immune infiltrates without prognostic specificity: a study based on the cancer genome atlas data
Received:October 10, 2022  Revised:May 29, 2023
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KeyWord:Enhancer of zeste homolog 2; lung cancer; diagnosis; prognosis; immune infiltrating
Author NameAffiliationE-mail
Daijun Xing Cardiac Center (Department of Vascular Surgery), The Affiliated Qingdao Hiser Hospital of Qingdao University (Qingdao Hospital of Traditional Chinese Medicine), Qingdao 266033, China  
Fuman Wang Cardiac Center (Department of Vascular Surgery), The Affiliated Qingdao Hiser Hospital of Qingdao University (Qingdao Hospital of Traditional Chinese Medicine), Qingdao 266033, China  
Min Qi Cardiac Center (Department of Vascular Surgery), The Affiliated Qingdao Hiser Hospital of Qingdao University (Qingdao Hospital of Traditional Chinese Medicine), Qingdao 266033, China  
Xiaokun Wang Cardiac Center (Department of Vascular Surgery), The Affiliated Qingdao Hiser Hospital of Qingdao University (Qingdao Hospital of Traditional Chinese Medicine), Qingdao 266033, China  
Xu Zhu Cardiac Center (Department of Vascular Surgery), The Affiliated Qingdao Hiser Hospital of Qingdao University (Qingdao Hospital of Traditional Chinese Medicine), Qingdao 266033, China  
Yufeng Cao Cardiac Center (Department of Vascular Surgery), The Affiliated Qingdao Hiser Hospital of Qingdao University (Qingdao Hospital of Traditional Chinese Medicine), Qingdao 266033, China  
Zhengtong Zhao Cardiac Center (Department of Vascular Surgery), The Affiliated Qingdao Hiser Hospital of Qingdao University (Qingdao Hospital of Traditional Chinese Medicine), Qingdao 266033, China  
Gaoyang Lin Department of Thoracic Surgery, The Affiliated Qingdao Hiser Medical Center of Qingdao University Medical College lingaoyang1988@126.com 
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Abstract:
      Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2). Dysregulation of EZH2 causes alteration of gene expression and functions, thereby promoting cancer development. Recent studies suggest that EZH2 has a potential prognostic role in patients with nonsmall cell lung cancer (NSCLC). However, the prognostic value of EZH2 expression levels in NSCLC is controversial. In this study, we evaluated the prognostic value in lung cancer (LC-LUAD/LUSC) based on data from The Cancer Genome Atlas (TCGA) database. Kruskal-Wallis test, Wilcoxon signed-rank test, and logistic regression were used to evaluate the relationship between EZH2 expression and clinicopathological features. Cox regression and the Kaplan-Meier method were adopted to evaluate prognosis-related factors. Gene set enrichment analysis (GSEA) was performed to identify the key pathways related to EZH2. The correlations between EZH2 and cancer immune infiltrates were investigated by single-sample Gene Set Enrichment Analysis (ssGSEA). EZH2 was found to be up regulated with amplification in tumor tissues in multiple LC cohorts. High EZH2 expression was associated with poorer overall survival (OS). GSEA suggested that EZH2 regulates innate immune system, ECM affiliated, matrisome, surfactant metabolism. Notably, ssGSEA indicated that EZH2 expression was positively correlated with infiltrating levels of Th2 cells and significantly negatively correlated with mast cell infiltration level. These results suggest that EZH2 is associated with LC immune infiltration and significantly over-expressed in lung cancer, and its diagnostic value is better than prognosis, which lays a foundation for further study of the immunomodulatory role of EZH2 in LC.
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