| liangdonghong,Zhennan Niu,Xiaofang Sun,Changjuan Meng,Zhuang Liu. Risk factors of lymph node metastasis in rectal neuroendocrine tumors. Oncol Transl Med, 2022, 8: 186-190. |
| 影响直肠神经内分泌肿瘤发生淋巴结转移的危险因素分析 |
| Risk factors of lymph node metastasis in rectal neuroendocrine tumors |
| Received:March 21, 2022 Revised:August 30, 2022 |
| DOI：10.1007/s10330-022-0562-2 |
| 中文关键词: 直肠神经内分泌肿瘤；淋巴结转移；危险因素 |
| 英文关键词: rectal neuroendocrine tumor; lymph node metastasis; risk factors |
| 基金项目:邢台市重点研发计划项目(2020ZC277) |
| Author Name | Affiliation | E-mail | | liangdonghong | 消化内镜室 | futuanfu52831@163.com | | Zhennan Niu | Department of Endoscopy, Xingtai Third Hospital | | | Xiaofang Sun | Department of Endoscopy, Xingtai Third Hospital | | | Changjuan Meng | Department of Pathology, Xingtai Third Hospital | | | Zhuang Liu* | Department of Endoscopy, Xingtai Third Hospital | |
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| 中文摘要: |
| 目的：探讨影响直肠神经内分泌肿瘤(RNENs)发生淋巴结转移的危险因素。方法：选择168例接受了根治性外科切除的RNENs患者为研究对象，收集临床病理和生存数据，回顾性分析影响患者发生淋巴结转移的危险因素。采用Kaplan-Meier法和Cox比例风险模型评估影响患者预后的独立性危险因素。结果：(1)单因素分析显示，患者年龄、肿瘤直径、肿瘤功能、Grade分级和T分期与淋巴结转移相关(P＜0.05)。年龄越高、肿瘤直径越大、功能性肿瘤、Grade分级和T分期越高，RENEs患者发生淋巴结转移的风险就越高。多元logistic回归分析显示，肿瘤大小、Grade分级和T分期影响是RENEs患者淋巴结转移的独立危险因素。(2)全组168例患者，死亡25例，总体生存率为85.1%(143/168)。Kaplan-Meier分析发现，淋巴结转移患者5年OS为40.0%(10/25)，无淋巴结转移患者5年OS为93.0%(133/143)；两组间差异有统计学意义(χ2 =29.64,P=0.00)，合并淋巴结转移的RENEs患者预后显著较差。同时，肿瘤直径较大(χ2 =22.75,P=0.000)、Grade分级较高(χ2 =121.70,P=0.000)患者的预后也显著较差。(3)Cox多因素分析结果显示，肿瘤直径(HR=1.985,P=0.008)、Grade分级(HR=3.416,P=0.004)、T分期(HR=2.413,P=0.014)、淋巴结转移(HR=3.119,P=0.000)是影响RENEs患者预后的独立性危险因素。结论：肿瘤大小、Grade分级和T分期是影响RENEs患者发生淋巴结转移及预后的主要危险因素，在术前应充分评估。 |
| 英文摘要: |
| Objective The aim of this study was to investigate the risk factors of lymph node metastasis in rectal
neuroendocrine neoplasms (RNENs).
Methods We enrolled 168 patients with RNENs as the research object, and their clinicopathological and
survival data were collected. The risk factors affecting lymph node metastasis were analyzed retrospectively,
and independent risk factors affecting prognosis were evaluated.
Results Analysis showed that age, tumor diameter, tumor function, grade, and T stage were correlated
with lymph node metastasis (P < 0.05). Multiple logistic regression analysis showed that tumor size, grade,
and T stage were independent risk factors for lymph node metastasis in patients with RNENs. Kaplan–
Meier analysis showed that the 5-year overall survival (OS) of patients with lymph node metastasis was
40.0% (10/25), and that of patients without lymph node metastasis was 93.0% (133/143). The prognosis of
RNENs patients with lymph node metastasis along with patients with large tumor diameter and high grade
was poor. Cox multivariate analysis showed that tumor diameter (HR = 1.985, P = 0.008), grade (HR =
3.416, P = 0.004), T stage (HR = 2.413, P = 0.014), and lymph node metastasis (HR = 3.119, P = 0.000)
were independent risk factors affecting the prognosis of patients with RNENs.
Conclusion Tumor size, grade, and T stage are the main risk factors for lymph node metastasis and
prognosis in patients with RNENs. These risk factors should be fully evaluated before surgery. |
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