| liangdonghong,Zhennan Niu,Xiaofang Sun,Changjuan Meng,Zhuang Liu. Risk factors of lymph node metastasis in rectal neuroendocrine tumors. Oncol Transl Med, 2022, 8: 186-190. |
| Risk factors of lymph node metastasis in rectal neuroendocrine tumors |
| Received:March 21, 2022 Revised:August 30, 2022 |
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| KeyWord:rectal neuroendocrine tumor; lymph node metastasis; risk factors |
| Author Name | Affiliation | E-mail | | liangdonghong | 消化内镜室 | futuanfu52831@163.com | | Zhennan Niu | Department of Endoscopy, Xingtai Third Hospital | | | Xiaofang Sun | Department of Endoscopy, Xingtai Third Hospital | | | Changjuan Meng | Department of Pathology, Xingtai Third Hospital | | | Zhuang Liu | Department of Endoscopy, Xingtai Third Hospital | |
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| Abstract: |
| Objective The aim of this study was to investigate the risk factors of lymph node metastasis in rectal
neuroendocrine neoplasms (RNENs).
Methods We enrolled 168 patients with RNENs as the research object, and their clinicopathological and
survival data were collected. The risk factors affecting lymph node metastasis were analyzed retrospectively,
and independent risk factors affecting prognosis were evaluated.
Results Analysis showed that age, tumor diameter, tumor function, grade, and T stage were correlated
with lymph node metastasis (P < 0.05). Multiple logistic regression analysis showed that tumor size, grade,
and T stage were independent risk factors for lymph node metastasis in patients with RNENs. Kaplan–
Meier analysis showed that the 5-year overall survival (OS) of patients with lymph node metastasis was
40.0% (10/25), and that of patients without lymph node metastasis was 93.0% (133/143). The prognosis of
RNENs patients with lymph node metastasis along with patients with large tumor diameter and high grade
was poor. Cox multivariate analysis showed that tumor diameter (HR = 1.985, P = 0.008), grade (HR =
3.416, P = 0.004), T stage (HR = 2.413, P = 0.014), and lymph node metastasis (HR = 3.119, P = 0.000)
were independent risk factors affecting the prognosis of patients with RNENs.
Conclusion Tumor size, grade, and T stage are the main risk factors for lymph node metastasis and
prognosis in patients with RNENs. These risk factors should be fully evaluated before surgery. |
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