| Zhihua Wang. Metabolic reprogramming drives homeostasis and specialization of regulatory T cells in cancer. Oncol Transl Med, 2022, 8: 18-27. |
| Metabolic reprogramming drives homeostasis and specialization of regulatory T cells in cancer |
| Received:February 10, 2022 Revised:February 10, 2022 |
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| KeyWord:cancer immunity; FOXP3; T cells; tumor microenvironment |
| Author Name | Affiliation | E-mail | | Zhihua Wang | Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China | zhwang_hust@hotmail.com |
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| Abstract: |
| Transcription factor forkhead box P3 (Foxp3)+ regulatory T (Treg) cells are receiving increasing attention
because this unique subset of T cells is characterized by exerting negative regulatory function of cellular
immune responses. The resultant suppression of anti-tumor immunity in the tumor microenvironment
(TME) is regarded as a major obstacle to immunotherapies in a plethora of cancers. Thus, an integrated
understanding of the intrinsic correlation between tumors and Treg cell biology is urgently required.
This review focuses on the peculiar biochemical effects of tumor metabolic environments on Tregs and
how Tregs orchestrate internal metabolic switches and altered metabolic pathways and molecules to
survive and function after the remodeling of homeostasis and specialization, providing new directions for
immunotherapies. |
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