| Xiaoying Quan,Xiaoyan Chen,Lei Lei,Xiaoli Jia,Chunzhi Wu,Bin Ye. Case report of a mixed pulmonary large cell neuroendocrine carcinoma. Oncol Transl Med, 2022, 8: 311-313. |
| 复合型肺大细胞神经内分泌癌1例 |
| Case report of a mixed pulmonary large cell neuroendocrine carcinoma |
| Received:January 17, 2022 Revised:December 20, 2022 |
| DOI：10.1007/s10330-022-0554-4 |
| 中文关键词: 肺大细胞神经内分泌癌；肺腺癌；诊断；治疗 |
| 英文关键词: pulmonary large cell neuroendocrine carcinoma; pulmonary adenocarcinoma; diagnosis; treatment |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Xiaoying Quan | Department of Medical Oncology, The Sixth People''''s Hospital of Chengdu | 1193084163@qq.com | | Xiaoyan Chen | Department of Medical Oncology, The Sixth People''''s Hospital of Chengdu | | | Lei Lei | Department of Medical Oncology, The Sixth People''''s Hospital of Chengdu | | | Xiaoli Jia | Department of Medical Oncology, The Sixth People''''s Hospital of Chengdu | | | Chunzhi Wu | Department of Medical Oncology, The Sixth People''''s Hospital of Chengdu | | | Bin Ye* | Department of Medical Oncology, The Sixth People''''s Hospital of Chengdu | 354539616@qq.com |
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| 中文摘要: |
| 1例57岁男性患者体检CT发现右肺中叶肿物，纤支镜活检示查见肿瘤细胞，行手术切除。术后病理为复合型肺大细胞神经内分泌癌，基因检测EGFR 21外显子L858R突变。术后行6周期依托泊苷联合顺铂化疗，化疗结束后予奥西替尼靶向治疗。随访至今，患者未见肿瘤复发转移征象。 |
| 英文摘要: |
| A 57 year-old male patient was found to have a lesion in the middle lobe of his right lung using chest
computed tomography (CT). Tumor cells were detected, and surgical excision was performed. The
patient was diagnosed with mixed large cell neuroendocrine carcinoma, and underwent six cycles of a
chemotherapy regimen comprising etoposide combined with cisplatin. Genetic testing revealed an EGFR
mutation, which prompted oxitinib-targeted therapy. To date, no signs of recurrence or metastasis have
been reported. |
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