| Lili Shen,Chao Li,Jingwen Wang,Jin Fan,Ji Zhu. CEA levels predict tumor response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. Oncol Transl Med, 2022, 8: 180-185. |
| CEA levels predict tumor response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer |
| Received:January 05, 2022 Revised:July 30, 2022 |
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| KeyWord:locally advanced rectal cancer (LARC); carcinoembryonic antigen (CEA); neoadjuvant chemoradiotherapy; pathological complete response (pCR) |
| Author Name | Affiliation | E-mail | | Lili Shen | Department of Oncology, Nantong Haimen People’s Hospital, Haimen Hospital of Nantong University | shenlilimao2012@163.com | | Chao Li | Department of Radiotherapy, Huashan Hospital, Fudan University | | | Jingwen Wang | Department of Radiation Oncology, Fudan University Shanghai Cancer Center | | | Jin Fan | Department of Radiation Oncology, Fudan University Shanghai Cancer Center | | | Ji Zhu | Department of Radiation Oncology, Fudan University Shanghai Cancer Center | |
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| Abstract: |
| Objective The aim of this study was to evaluate the impact of serum carcinoembryonic antigen (CEA) in
the prediction of pathological complete response (pCR) in locally advanced rectal cancer (LARC) patients
treated with neoadjuvant chemoradiotherapy (nCRT).
Methods A total of 925 LARC patients who underwent nCRT followed by TME between March 2006
and February 2018 were enrolled at Fudan University Shanghai Cancer Center. Using logistic regression
models, we investigated the associations between serum CEA levels and pathological complete remission
(pCR). Further stratified analyses were performed according to different CEA thresholds.
Results We found that pre-nCRT CEA and post-nCRT CEA were negatively correlated with pCR
(P < 0.001). Stratified analyses revealed that when the CEA cutoff value was set to 5 ng/mL, 10.6% of
patients with post-nCRT CEA levels > 5 ng/mL achieved pCR. Meanwhile, when the CEA cutoff value was
set to 10 ng/mL, only 6.8% of the patients with post-nCRT CEA levels > 10 ng/mL achieved pCR.
Conclusion In summary, pre- and post-nCRT CEA levels ≤ 5 ng/mL were favorable predictors of pCR
in LACR patients, and the “watch and wait” strategy is not recommended for patients with post-nCRT CEA
levels > 10 ng/mL. |
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