| Yaqiong Ni,Wei Yao,Yunsheng Wang,Hui Wang,Qinjiang Liu. Effects of rearranged during transfection mutation on calcitonin and procalcitonin expression in sporadic medullary thyroid carcinoma. Oncol Transl Med, 2022, 8: 121-125. |
| Effects of rearranged during transfection mutation on calcitonin and procalcitonin expression in sporadic medullary thyroid carcinoma |
| Received:November 17, 2021 Revised:June 19, 2022 |
| View Full Text View/Add Comment Download reader |
| KeyWord:sporadic medullary thyroid carcinoma (SMTC); procalcitonin; calcitonin: rearranged during transfection (RET) |
| Author Name | Affiliation | E-mail | | Yaqiong Ni | Gansu provincial Cancer Hospital | 13919306776@163.com | | Wei Yao | Gansu provincial Cancer Hospital | | | Yunsheng Wang | Gansu provincial Cancer Hospital | | | Hui Wang | Gansu provincial Cancer Hospital | | | Qinjiang Liu | Gansu provincial Cancer Hospital | liuqj99@126.com |
|
| Hits: 2483 |
| Download times: 2949 |
| Abstract: |
| Objective The aim of this study was to investigate the effects of rearranged during transfection (RET)
mutation on the expressions of calcitonin (CTn) and procalcitonin (PCT) in sporadic medullary thyroid
carcinoma (SMTC).
Methods RET mutation was detected by polymerase chain reaction direct sequencing in 64
cases of SMTC, and the expression levels of CTn and PCT in SMTC tissues were detected using the
immunohistochemical streptavidin-perosidase (SP) method. The effect of RET mutations on the expression
of CTn and PCT along with its relationship with clinicopathological parameters were analyzed.
Results The expression rates of CTn and PCT in SMTC tissues were 90.6% (58/64) and 67.2% (43/64),
respectively. CTn and PCT expression were found to be associated with tumor size and lymph node
metastasis (P < 0.05) but not with gender, age, or tumor capsule invasion (P > 0.05). There was a significant
correlation between CTn and PCT expression (r = 0.269, P = 0.041), and the intensity of positive CTn
expression was positively correlated with RET mutation (r = 0.507, P = 0.000). However, PCT expression
was not associated with RET mutation (r = 0.188, P = 0.136).
Conclusion High expression of CTn and PCT was associated with the progression of medullary
carcinoma, and the intensity of CTn expression was associated with RET mutation. PCT may provide
valuable information for the diagnosis and prognosis of SMTC. |
| Close |
|
|
|