| Wei Gao,Xiaoxiao Liu,Hongbing Ma. Effect of radiotherapy on tumor markers and serum immune-associated cells in patients with esophageal cancer. Oncol Transl Med, 2021, 7: 275-278. |
| 放疗对食管癌患者血清免疫细胞及肿瘤标志物的影响 |
| Effect of radiotherapy on tumor markers and serum immune-associated cells in patients with esophageal cancer |
| Received:November 06, 2021 Revised:December 16, 2021 |
| DOI：10.1007/s10330-021-0532-2 |
| 中文关键词: 放射治疗；食管癌；免疫细胞；肿瘤标记物 |
| 英文关键词: radiotherapy; esophageal cancer; tumor markers, immune-associated cells |
| 基金项目:肿瘤外泌体miRNA调控Treg细胞在食管鳞癌放射抗拒中的作用及机制，2019-01至2022-12，国家自然科学基金委员会，面上项目81872471 |
| Author Name | Affiliation | E-mail | | Wei Gao | The Hospital of Xi ''an Architectural Science and Techology University,Xi ''an China | gaoxian118@163.com | | Xiaoxiao Liu | The Second Affiliated Hospital of Xi ''an Jiaotong University,Xi ''an China | | | Hongbing Ma* | Department of Oncology radiotherapy,The Second Affiliated Hospital of Xi ''an Jiaotong University,Xi ''an China | mhbxian@126.com |
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| 中文摘要: |
| 摘要：目的探讨放射治疗对食管癌患者血清免疫细胞和肿瘤标志物的影响。方法选择我院2016年10月至2020年7月收治的87例食管癌患者为研究组，所有患者均接受放疗。选择同期在我院体检的87名健康志愿者作为对照组，比较两组患者血清免疫相关细胞和肿瘤标志物的变化。结果研究组放疗前CEA、CA125、CA72-4、CYFRA21-1、SCC水平均高于对照组，差异有统计学意义（P<0.05）。研究组放疗后CEA、CA125、CA72-4、CYFRA21-1、SCC水平均低于放疗前，但仍高于对照组，差异有统计学意义（P<0.05）。研究组放疗前后CD3、CD4、CD4/CD8、NK细胞水平均低于对照组，而Treg细胞、CD8水平均高于对照组，差异有统计学意义（P<0.05）。观察组放疗后CD3、CD4、CD4/CD8水平均低于放疗前，CD8水平高于放疗前，差异有统计学意义（P<0.05）。结论放疗可有效降低食管癌患者血清肿瘤标志物水平，但对机体免疫功能有不良影响。 |
| 英文摘要: |
| Objective This study aimed to investigate the effect of radiotherapy on serum immune-associated cells
and tumor markers in patients with esophageal cancer.
Methods A total of 87 patients with esophageal cancer admitted to our hospital between October 2016
and July 2020 were selected as the observation group, and all patients received radiotherapy. A total of
87 healthy volunteers who underwent physical examination at our hospital during the same period were
selected as the control group in order to compare the changes in serum immune-associated cells and tumor
markers between the two groups.
Results The levels of carcinoembryonic antigen (CEA), cancer antigen (CA) 125, CA72-4, C-terminus of
cytokeratin (CYFRA) 21-1, and squamous cell carcinoma (SCC) antigen in the observation group before
radiotherapy were higher than those in the control group, and the differences were significant (P < 0.05).
The levels of CEA, CA125, CA72-4, CYFRA21-1, and SCC antigen in the research group after radiotherapy
were significantly lower than those before radiotherapy, but were still significantly higher than those in the
control group (P < 0.05). The levels of CD3+, CD4+, CD4+/CD8+, and natural killer cells in the research
group before and after radiotherapy were significantly lower, while the levels of Treg and CD8+ cells were
significantly higher than those in the control group (P < 0.05). The levels of CD3+, CD4+, and CD4+/CD8+
cells in the observation group after radiotherapy were lower, while the levels of CD8+ cells were significantly
higher than those before radiotherapy (P < 0.05).
Conclusion Radiotherapy can effectively reduce the level of serum tumor markers in patients with
esophageal cancer; these antigens and cells can be used as tumor markers of esophageal cancer in order
to determine its prognosis. However, radiotherapy has adverse effects on the immune function of the body.
The reasons behind this need to be further studied and analyzed. |
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