| Wei Gao,Xiaoxiao Liu,Hongbing Ma. Effect of radiotherapy on tumor markers and serum immune-associated cells in patients with esophageal cancer. Oncol Transl Med, 2021, 7: 275-278. |
| Effect of radiotherapy on tumor markers and serum immune-associated cells in patients with esophageal cancer |
| Received:November 06, 2021 Revised:December 16, 2021 |
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| KeyWord:radiotherapy; esophageal cancer; tumor markers, immune-associated cells |
| Author Name | Affiliation | E-mail | | Wei Gao | The Hospital of Xi ''an Architectural Science and Techology University,Xi ''an China | gaoxian118@163.com | | Xiaoxiao Liu | The Second Affiliated Hospital of Xi ''an Jiaotong University,Xi ''an China | | | Hongbing Ma | Department of Oncology radiotherapy,The Second Affiliated Hospital of Xi ''an Jiaotong University,Xi ''an China | mhbxian@126.com |
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| Abstract: |
| Objective This study aimed to investigate the effect of radiotherapy on serum immune-associated cells
and tumor markers in patients with esophageal cancer.
Methods A total of 87 patients with esophageal cancer admitted to our hospital between October 2016
and July 2020 were selected as the observation group, and all patients received radiotherapy. A total of
87 healthy volunteers who underwent physical examination at our hospital during the same period were
selected as the control group in order to compare the changes in serum immune-associated cells and tumor
markers between the two groups.
Results The levels of carcinoembryonic antigen (CEA), cancer antigen (CA) 125, CA72-4, C-terminus of
cytokeratin (CYFRA) 21-1, and squamous cell carcinoma (SCC) antigen in the observation group before
radiotherapy were higher than those in the control group, and the differences were significant (P < 0.05).
The levels of CEA, CA125, CA72-4, CYFRA21-1, and SCC antigen in the research group after radiotherapy
were significantly lower than those before radiotherapy, but were still significantly higher than those in the
control group (P < 0.05). The levels of CD3+, CD4+, CD4+/CD8+, and natural killer cells in the research
group before and after radiotherapy were significantly lower, while the levels of Treg and CD8+ cells were
significantly higher than those in the control group (P < 0.05). The levels of CD3+, CD4+, and CD4+/CD8+
cells in the observation group after radiotherapy were lower, while the levels of CD8+ cells were significantly
higher than those before radiotherapy (P < 0.05).
Conclusion Radiotherapy can effectively reduce the level of serum tumor markers in patients with
esophageal cancer; these antigens and cells can be used as tumor markers of esophageal cancer in order
to determine its prognosis. However, radiotherapy has adverse effects on the immune function of the body.
The reasons behind this need to be further studied and analyzed. |
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