| Sisi Wang,Chuyang Lin (Co-first author),Chuyang Lin,Tingting Xi,Yu Tong,Jinlin Wu. Relationship between IKZF1 polymorphisms and the risk of acute lymphoblastic leukemia: a meta-analysis. Oncol Transl Med, 2022, 8: 217-225. |
| IZKF1基因多态性与急性淋巴细胞白血病发病风险相关性的Meta分析 |
| Relationship between IKZF1 polymorphisms and the risk of acute lymphoblastic leukemia: a meta-analysis |
| Received:October 11, 2021 Revised:October 10, 2022 |
| DOI：10.1007/s10330-021-0527-7 |
| 中文关键词: IZKF1；基因多态性；急性淋巴细胞白血病；Meta分析；系统评价；病例-对照研究 |
| 英文关键词: IKZF1; gene polymorphism; acute lymphoblastic leukemia (ALL); meta-analysis; systematic reviews; case-control study |
| 基金项目:新生儿国家临床重点专科建设项目 (1311200003303）、四川省科技厅技术创新研发项目 (2021YJ0211) 、四川省卫健委普及应用项目(20PJ070) |
| Author Name | Affiliation | E-mail | | Sisi Wang | Department of Pediatrics
Key Laboratory of Birth Defects and Related Disease of Women and Children, Ministry of Education
West China Second University Hospital, Sichuan University, Chengdu 610041, China | wssmeitan@163.com | | Chuyang Lin (Co-first author) | | | | Chuyang Lin | Department of Pediatrics
Key Laboratory of Birth Defects and Related Disease of Women and Children, Ministry of Education
West China Second University Hospital, Sichuan University, Chengdu 610041, China | | | Tingting Xi | Department of Pediatrics
Key Laboratory of Birth Defects and Related Disease of Women and Children, Ministry of Education
West China Second University Hospital, Sichuan University, Chengdu 610041, China | | | Yu Tong | Department of Pediatrics
Key Laboratory of Birth Defects and Related Disease of Women and Children, Ministry of Education
West China Second University Hospital, Sichuan University, Chengdu 610041, China | | | Jinlin Wu* | Department of Pediatrics
Key Laboratory of Birth Defects and Related Disease of Women and Children, Ministry of Education
West China Second University Hospital, Sichuan University, Chengdu 610041, China | wujl_2000@sina.com |
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| 中文摘要: |
| 目的 系统评价 IZKF1 基因多态性与急性淋巴细胞白血病发病风险的相关性。方法 计算机检索 PubMed、EMbase、The Cochrane Library数据库，搜集有关 IZKF1 基因多态性与急性淋巴细胞白血病发病风险相关性的病例-对照研究，检索时限均从建库至 2020 年 11 月。由 2 名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后，采用 Stata 14.0 软件进行 Meta 分析。结果 共纳入48个病例-对照研究，包括病例组10520例、对照组44049例。Meta 分析结果显示，IZKF1 基因 rs4132061 位点、rs11978267 位点均与急性淋巴细胞白血病发病风险存在显著相关性。结论 当前证据表明，IZKF1基因rs4132061 位点、rs11978267位点与B细胞型急性淋巴细胞白血病发病风险存在显著相关性。 |
| 英文摘要: |
| Objective The aim of the study was to systematically evaluate the correlation between IKZF1
polymorphisms and the risk of acute lymphoblastic leukemia.
Methods Computer databases including PubMed, EMBASE, and Web of Science were searched for
case-control studies on the association between IKZF1 polymorphisms and the risk of acute lymphoblastic
leukemia. The retrieval period was from the establishment of the database to November 2020. Two
researchers independently screened the literature, extracted the data, evaluated the risk of bias in the
included studies, and used Stata 14.0 software for meta-analysis.
Results A total of 48 case-control studies were included, with 10 520 and 44 049 cases in the case and
control groups, respectively. The meta-analysis results showed that rs4132061 and rs11978267 of IKZF1
were significantly correlated with the risk of acute lymphoblastic leukemia (ALL).
Conclusion Current evidence indicates that rs4132061 and rs11978267 of IKZF1 are significantly
associated with the risk of B-cell ALL. |
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