| Li Zheng,Jin Wang,Lin Ang,Jin Huang,Min Zhao. Spindle epithelial tumor with thymus-like differentiation：A case report and literature review. Oncol Transl Med, 2022, 8: 150-153. |
| 伴胸腺样分化的梭形细胞肿瘤1例并文献复习 |
| Spindle epithelial tumor with thymus-like differentiation：A case report and literature review |
| Received:September 11, 2021 Revised:May 27, 2022 |
| DOI：10.1007/s10330-021-0520-0 |
| 中文关键词: 伴胸腺样分化的梭形细胞肿瘤；免疫组化 |
| 英文关键词: spindle epithelial tumor; thymus-like differentiation; immunohistochemistry |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Li Zheng | The Second People’s Hospital of Hefei | zhengli352@163.com | | Jin Wang | The Second People’s Hospital of Hefei | | | Lin Ang | The Second People’s Hospital of Hefei | | | Jin Huang | The Second People’s Hospital of Hefei | | | Min Zhao* | The Second People’s Hospital of Hefei | Zhao.Min.hi@163.com |
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| 中文摘要: |
| 伴胸腺样分化的梭形细胞肿瘤（Spindle cell tumor with thymus-like differentiation，SETTLE）是一类罕见的甲状腺低度恶性肿瘤，主要发生于甲状腺内或周围。国内文献报道不到10例，国外文献报道约50例左右。我们报道了一例少见的发生于甲状腺周围颈部软组织的SETTLE，发生于一名41岁的男性患者。 肿瘤组织以梭形细胞成份为主，其间可见散在的腺样结构。免疫组化腺上皮成份CK、CK19阳性，梭形细胞CK、Vimentin、Bcl-2阳性。手术切除是SETTLE的主要治疗方式，该例患者行颈部包块切除术，术后8个月无复发与转移。 |
| 英文摘要: |
| Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a rare, low-grade malignant neoplasm
that mainly occurs in the thyroid gland or its perimeter. Fewer than 10 cases of SETTLE have been reported
in the Chinese literature, whereas approximately 50 cases have been reported in the international literature.
We report a rare case of SETTLE that occurred in the soft tissues of the neck around the thyroid gland in a
41-year-old man. The neoplastic tissue, which mainly consisted of spindle epithelial components, included
sporadically visible thymus-like structures. Immunohistochemistry demonstrated CK and CK19 positivity
in the thymic epithelial components and CK, vimentin, and Bcl-2 positivity in the spindle cells. Surgical
resection is the main treatment option for SETTLE. This patient underwent mass resection of the neck, and
no recurrence or metastasis was observed even at 8 months postoperatively |
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