| zhangyichao. Prognostic value of serum carcinoembryonic antigen combined with nutritional status control score in patients with colorectal cancer. Oncol Transl Med, 2022, 8: 135-139. |
| 血清癌胚抗原联合营养状况控制评分对结直肠癌患者预后的判断价值 |
| Prognostic value of serum carcinoembryonic antigen combined with nutritional status control score in patients with colorectal cancer |
| Received:September 03, 2021 Revised:May 19, 2022 |
| DOI：10.1007/s10330-021-0516-6 |
| 中文关键词: 结直肠癌；癌胚抗原；营养状况控制评分 |
| 英文关键词: colorectal cancer; carcinoembryonic antigen; nutritional status control score |
| 基金项目:四川省科技厅科技支撑计划项目(项目编号：2018SZ2311) |
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| 中文摘要: |
| 目的：探讨血清癌胚抗原(CEA)联合营养状况控制评分(CONUT)对结直肠癌患者预后的判断价值。方法：对261例在本院接受结直肠癌手术的患者进行回顾性研究。根据ROC曲线分析结果，分别以CONUT=3分、CEA=5 ng/mL，将患者分为高CONUT评分组和低CONUT评分组，高CEA水平组(<5 ng/mL)和低CEA水平组(≥5 ng/mL组)，统计分析CONUT评分、CEA水平及二者联合检测对患者预后及临床病理参数的影响。结果：（1）不同CONUT评分于患者年龄、肿瘤直径、分化类型、T分期有明显相关性(P＜0.05)，患者年龄越大、肿瘤直径越大、未分化型肿瘤、T分期越高，患者的CONUT评分就越高。（2）75例患者在随访期内死亡，45例死于结直肠癌进展或复发。低CONUT评分组患者的5年OS率(75.8%，138/182)明显高于高CONUT评分组(54.4%,43/79)，差异具有统计学意义(P<0.01)。低CEA患者5年OS率(82.6%,142/172)明显高于高CEA患者(43.8%,39/89)(P<0.01)，差异具有统计学意义(P<0.01)。（3）根据血清CEA水平及CONUT评分，将患者分为CEAlow/CONUTlow组(n=128)、CEAlow/CONUThigh组(n=44)、CEAhigh/CONUTlow组(n=53)和CEAhigh/CONUThigh组(n=36)，其5年生存率率分别为84.7%、69%、55.3%和36.1%，差异具有统计学意义(P<0.01)，（4）COX多因素分析显示，年龄、CONUT评分、CEA联合CONUT评分、淋巴结转移和远处转移均是影响结直肠癌患者预后的独立性危险因素。结论：联合CEA检测及CONUT评分可更准确判断结直肠癌患者预后。 |
| 英文摘要: |
| Objective To investigate the prognostic value of serum carcinoembryonic antigen (CEA) and controlling
nutritional status (CONUT) score in patients with colorectal cancer.
Methods We retrospectively studied 261 patients with colorectal cancer in our hospital. The patients were
divided into two groups by CONUT = 3 and CEA = 5 ng/mL, and the effects of CONUT score and CEA level
on the prognosis and clinicopathological parameters were statistically analyzed.
Results (1) Different CONUT scores were significantly correlated with age, tumor diameter, differentiation
type, and T stage (P < 0.05). The older the patient was, the larger the tumor diameter, undifferentiated
tumor, and T stage were, the higher the CONUT score was. (2) Seventy-five patients died during the
follow-up period, and 45 patients died of progression or recurrence of colorectal cancer. The 5-year overall
survival (OS) rate of the low CONUT score group was significantly higher than that of the high CONUT
score group, and the 5-year OS rate of the low CEA group was significantly higher than that of the high
CEA group; the difference was statistically significant (P < 0.01). (3) According to the serum CEA level
and CONUT score, the 5-year survival rates of CEAlow/CONUTlow, CEAlow/CONUThigh, CEAhigh/CONUTlow,
and CEAhigh/CONUThigh were 84.7%, 69%, 55.3%, and 36.1% respectively, with statistical significance (P
<0.01). (4) The Cox multivariate analysis showed that age, CONUT score, CEA combined with CONUT
score, lymph node metastasis, and distant metastasis were independent risk factors for the prognosis of
colorectal cancer patients.
Conclusion: The combination of CEA detection and CONUT score can more accurately judge the prognosis
of colorectal cancer patients. |
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