| Guangyu Wang. Effect of UBR5 on the tumor microenvironment and its related mechanisms in cancer. Oncol Transl Med, 2021, 7: 294-304. |
| UBR5对肿瘤微环境的影响及在肿瘤中的相关机制 |
| Effect of UBR5 on the tumor microenvironment and its related mechanisms in cancer |
| Received:August 31, 2021 Revised:December 10, 2021 |
| DOI：10.1007/s10330-021-0515-5 |
| 中文关键词: UBR5；癌症；肿瘤；预后；生物标志物 |
| 英文关键词: UBR5; cancer; tumor; prognosis; biomarker |
| 基金项目:广西自然科学基金(NO. 2019GXNSFBA245032);广西科技计划项目（桂科 AD20238021）；广西肿瘤免疫与微环境调控重点实验室开放基金(NO:203030302008、203030302018、2020KF010);桂林市科学研究与技术开发项目（(NO. 20190218-5-5)）广西壮族自治区中青年教师基本能力培养计划资助项目(NO. 2021KY0496) |
| Author Name | Affiliation | E-mail | | Guangyu Wang* | The Second Affiliated Hospital of Guilin Medical University | 365879737@qq.com |
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| 中文摘要: |
| 摘要
目的 UBR5在多种恶性肿瘤中过表达，近年来被认为是一种潜在的肿瘤治疗靶点。此外，它与多种癌症的生长、预后、转移和治疗反应密切相关。虽然新出现的证据支持UBR5和癌症之间的关系，但可获得的癌症分析较少。
方法 利用在线数据库（TIMER2、GEPIA2、UALCAN、c-BioPortal、String）和生物信息学方法综合探讨UBR5基因在肿瘤中的表达水平及预后价值。
结果 UBR5基因在正常组织中的基因表达、生存率、基因突变、蛋白磷酸化、免疫浸润、细胞通路等特征与原发肿瘤组织明显不同。此外，“剪接体中的蛋白质加工”和“泛素介导的蛋白质水解”也为它们可能参与癌症的发展提供了依据。
结论 本研究为肿瘤免疫治疗新靶点和预后生物标志物的选择提供了新的思路。 |
| 英文摘要: |
| Objective UBR5, recently identified as a potential target for cancer therapeutics, is overexpressed in
multiple malignant tumors. In addition, it is closely associated with the growth, prognosis, metastasis, and
treatment response of multiple types of cancer. Although emerging evidence supports the relationship
between UBR5 and cancer, there are limited cancer analyses available.
Methods In this study, online databases (TIMER2, GEPIA2, UALCAN, c-BioPortal, STRING) were
employed to comprehensively explore expression levels and prognostic values of the UBR5 gene in cancer,
using bioinformatic methods.
Results We found that various characteristics of the UBR5 gene such as gene expression, survival
value, genetic mutation, protein phosphorylation, immune infiltration, and pathway activities in the normal
tissue were remarkably different from those in the primary tumor. Furthermore, “protein processing in
spliceosome” and “ubiquitin mediated proteolysis” have provided evidence for their potential involvement
in the development of cancer.
Conclusion Our findings may provide insights for the selection of novel immunotherapeutic targets and
prognostic biomarkers for cancer. |
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