| Guangyu Wang. Effect of UBR5 on the tumor microenvironment and its related mechanisms in cancer. Oncol Transl Med, 2021, 7: 294-304. |
| Effect of UBR5 on the tumor microenvironment and its related mechanisms in cancer |
| Received:August 31, 2021 Revised:December 10, 2021 |
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| KeyWord:UBR5; cancer; tumor; prognosis; biomarker |
| Author Name | Affiliation | E-mail | | Guangyu Wang | The Second Affiliated Hospital of Guilin Medical University | 365879737@qq.com |
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| Abstract: |
| Objective UBR5, recently identified as a potential target for cancer therapeutics, is overexpressed in
multiple malignant tumors. In addition, it is closely associated with the growth, prognosis, metastasis, and
treatment response of multiple types of cancer. Although emerging evidence supports the relationship
between UBR5 and cancer, there are limited cancer analyses available.
Methods In this study, online databases (TIMER2, GEPIA2, UALCAN, c-BioPortal, STRING) were
employed to comprehensively explore expression levels and prognostic values of the UBR5 gene in cancer,
using bioinformatic methods.
Results We found that various characteristics of the UBR5 gene such as gene expression, survival
value, genetic mutation, protein phosphorylation, immune infiltration, and pathway activities in the normal
tissue were remarkably different from those in the primary tumor. Furthermore, “protein processing in
spliceosome” and “ubiquitin mediated proteolysis” have provided evidence for their potential involvement
in the development of cancer.
Conclusion Our findings may provide insights for the selection of novel immunotherapeutic targets and
prognostic biomarkers for cancer. |
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