| siang wei. The role of OR51E2 in colon cancer and rectal adenocarcinoma and the potential underlying mechanism. Oncol Transl Med, 2022, 8: 140-145. |
| OR51E2与结肠癌和直肠腺癌的相关性分析及其可能的靶向调控机制 |
| The role of OR51E2 in colon cancer and rectal adenocarcinoma and the potential underlying mechanism |
| Received:August 19, 2021 Revised:June 21, 2022 |
| DOI：10.1007/s10330-021-0513-3 |
| 中文关键词: OR51E2，结肠癌，直肠癌，侵袭性，靶向微RNA，PPI，途径 |
| 英文关键词: OR51E2; colon cancer; rectal cancer; targeted microRNA; protein-protein interaction |
| 基金项目: |
| Author Name | Affiliation | E-mail | | siang wei | shanxi agricultural university | 978996802@qq.com |
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| 中文摘要: |
| 肠道微生物群产生的短链脂肪酸（SCFA）在肠道相关疾病的发生发展中起着积极的作用。OR51E2是一种新发现的SCFAs受体。目前，OR51E2与肠癌的研究还很有限。本研究旨在分析OR51E2与肠癌的关系。利用生物信息学方法分析OR51E2在肠道不同组成部分的蛋白表达、相关蛋白的调节、免疫细胞的浸润、OR51E2在结肠癌和直肠癌中的表达和预后，OR51E2在结肠、小肠和十二指肠中的表达水平相对较高。OR51E2与许多蛋白质分子之间存在相互作用。此外，OR51E2在结肠癌和直肠癌中的表达水平显著降低，并且OR51E2与免疫细胞之间存在正相关，这增加了结肠癌和直肠癌患者的生存率和预后风险（HR=1.5），还预测miR-96-5p和miR-1271-5-p可以靶向OR51E2。这项研究表明，OR51E2在维持结肠癌和直肠腺癌患者的生存中起着重要作用。 |
| 英文摘要: |
| Objective Short-chain fatty acids (SCFAs) produced by intestinal microbiota influence the pathogenesis
and development of several intestinal diseases. OR51E2 is a newly discovered SCFA receptor. At present,
research on the link between OR51E2 and intestinal cancer is limited. This study aimed to analyze the
relationship between OR51E2 and colorectal cancer.
Methods Bioinformatic analysis revealed the OR51E2 protein expression pattern in different parts of the
intestine, regulation of related proteins, and immune cell infiltration. The expression pattern and prognostic
value of OR51E2 in colon and rectal cancer was determined, and the miRNAs targeting OR51E2 were
predicted.
Results The expression level of OR51E2 was relatively high in the colon, small intestine, and duodenum.
In addition, OR51E2 expression level was significantly reduced in colon and rectal cancer. A positive
correlation between OR51E2 and immune cells was observed, which was associated with the survival
of patients with colon and rectal cancer (hazard ratio: 1.5). Further, miR-96-5p and miR-1271-5-p were
predicted to target OR51E2.
Conclusion OR51E2 plays an important positive role in the survival of patients with colon cancer and
rectal adenocarcinoma. |
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