Yong He,Yilin Wu,Yueyue Zhang,Qun Lv,Liming Li,Mingjun Jiang. Recent progress in understanding the role of genes in the pathogenesis of cutaneous squamous cell carcinoma. Oncol Transl Med, 2021, 7: 245-252.
Recent progress in understanding the role of genes in the pathogenesis of cutaneous squamous cell carcinoma
Received:August 02, 2021  Revised:December 21, 2021
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KeyWord:cutaneous squamous cell carcinoma (cSCC); genetics; pathogenesis; carcinogenesis
Author NameAffiliationPostcode
Yong He Chinese Academy of Medical Sciences and Peking Union Medical College 210042
Yilin Wu Chinese Academy of Medical Sciences and Peking Union Medical College 
Yueyue Zhang Affiliated Jinling Hospital, Medical School of Nanjing University 210002
Qun Lv Chinese Academy of Medical Sciences and Peking Union Medical College 
Liming Li Chinese Academy of Medical Sciences and Peking Union Medical College 
Mingjun Jiang Chinese Academy of Medical Sciences and Peking Union Medical College 210042
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Abstract:
      Cutaneous squamous cell carcinoma (cSCC) is the second most common skin tumor in humans. Ultraviolet (UV) radiation is an important environmental risk factor for cSCC; other risk factors include human papilloma virus (HPV) infection, chronic inflammation, and chronic wounds. A large proportion of patients present with an aggressive form of cSCC at the time of diagnosis, which is often accompanied by regional lymph node involvement and distant metastases. The long-term prognosis for these highly metastatic diseases is extremely poor, with a 10-year survival rate of less than 10%. Therefore, clarifying the pathogenesis of this tumor is of great significance and may contribute to the identification of novel biomarkers and development of new therapeutic strategies. In this review, we focus on the recent progress in genes related to the development of this tumor, intending to aid future investigations into the genetic alterations related to cSCC.
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