| Yong He,Yilin Wu,Yueyue Zhang,Qun Lv,Liming Li,Mingjun Jiang. Recent progress in understanding the role of genes in the pathogenesis of cutaneous squamous cell carcinoma. Oncol Transl Med, 2021, 7: 245-252. |
| 皮肤鳞癌相关致病基因的最新进展 |
| Recent progress in understanding the role of genes in the pathogenesis of cutaneous squamous cell carcinoma |
| Received:August 02, 2021 Revised:December 21, 2021 |
| DOI：10.1007/s10330-021-0511-1 |
| 中文关键词: 皮肤肿瘤；基因学；肿瘤发生 |
| 英文关键词: cutaneous squamous cell carcinoma (cSCC); genetics; pathogenesis; carcinogenesis |
| 基金项目: |
| Author Name | Affiliation | Postcode | | Yong He | Chinese Academy of Medical Sciences and Peking Union Medical College | 210042 | | Yilin Wu | Chinese Academy of Medical Sciences and Peking Union Medical College | | | Yueyue Zhang | Affiliated Jinling Hospital, Medical School of Nanjing University | 210002 | | Qun Lv | Chinese Academy of Medical Sciences and Peking Union Medical College | | | Liming Li | Chinese Academy of Medical Sciences and Peking Union Medical College | | | Mingjun Jiang* | Chinese Academy of Medical Sciences and Peking Union Medical College | 210042 |
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| 中文摘要: |
| 皮肤鳞状细胞癌是人类第二常见的皮肤肿瘤。紫外线照射是最重要的环境危险因素，其他危险因素包括人乳头状瘤病毒、慢性炎症和慢性伤口。大部分的病人确诊时已经是肿瘤晚期,伴有区域淋巴结和远处器官转移。这些高转移性疾病的长期预后非常差,十年生存率小于10%。因此,阐明肿瘤的发病机制具有重要意义,可能有助于发展新型生物标志物和新的治疗方法。在本文中,我们特别关注肿瘤发生过程中相关基因的最新进展，希望能对未来肿瘤发生机制相关研究有所帮助。 |
| 英文摘要: |
| Cutaneous squamous cell carcinoma (cSCC) is the second most common skin tumor in humans. Ultraviolet
(UV) radiation is an important environmental risk factor for cSCC; other risk factors include human papilloma
virus (HPV) infection, chronic inflammation, and chronic wounds. A large proportion of patients present
with an aggressive form of cSCC at the time of diagnosis, which is often accompanied by regional lymph
node involvement and distant metastases. The long-term prognosis for these highly metastatic diseases is
extremely poor, with a 10-year survival rate of less than 10%. Therefore, clarifying the pathogenesis of this
tumor is of great significance and may contribute to the identification of novel biomarkers and development
of new therapeutic strategies. In this review, we focus on the recent progress in genes related to the
development of this tumor, intending to aid future investigations into the genetic alterations related to cSCC. |
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