Yong He,Yilin Wu,Yueyue Zhang,Qun Lv,Liming Li,Mingjun Jiang. Recent progress in understanding the role of genes in the pathogenesis of cutaneous squamous cell carcinoma. Oncol Transl Med, 2021, 7: 245-252. |
Recent progress in understanding the role of genes in the pathogenesis of cutaneous squamous cell carcinoma |
Received:August 02, 2021 Revised:December 21, 2021 |
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KeyWord:cutaneous squamous cell carcinoma (cSCC); genetics; pathogenesis; carcinogenesis |
Author Name | Affiliation | Postcode | Yong He | Chinese Academy of Medical Sciences and Peking Union Medical College | 210042 | Yilin Wu | Chinese Academy of Medical Sciences and Peking Union Medical College | | Yueyue Zhang | Affiliated Jinling Hospital, Medical School of Nanjing University | 210002 | Qun Lv | Chinese Academy of Medical Sciences and Peking Union Medical College | | Liming Li | Chinese Academy of Medical Sciences and Peking Union Medical College | | Mingjun Jiang | Chinese Academy of Medical Sciences and Peking Union Medical College | 210042 |
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Abstract: |
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin tumor in humans. Ultraviolet
(UV) radiation is an important environmental risk factor for cSCC; other risk factors include human papilloma
virus (HPV) infection, chronic inflammation, and chronic wounds. A large proportion of patients present
with an aggressive form of cSCC at the time of diagnosis, which is often accompanied by regional lymph
node involvement and distant metastases. The long-term prognosis for these highly metastatic diseases is
extremely poor, with a 10-year survival rate of less than 10%. Therefore, clarifying the pathogenesis of this
tumor is of great significance and may contribute to the identification of novel biomarkers and development
of new therapeutic strategies. In this review, we focus on the recent progress in genes related to the
development of this tumor, intending to aid future investigations into the genetic alterations related to cSCC. |
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