| xiaofangzhang,Yanqing Zhang,Yungang Zhang,Chuanke Wan,Ling Xu,Ruimin Li. Special IgD-λ type multiple myeloma based on bone marrow cell morphology: A case report. Oncol Transl Med, 2021, 7: 239-241. |
| 1例骨髓细胞形态学特殊的IgD-?型多发性骨髓瘤 |
| Special IgD-λ type multiple myeloma based on bone marrow cell morphology: A case report |
| Received:June 23, 2021 Revised:October 27, 2021 |
| DOI：10.1007/s10330-021-0506-6 |
| 中文关键词: IgD-?型多发性骨髓瘤；骨髓细胞形态；免疫固定电泳；血清游离轻链 |
| 英文关键词: IgD-λ type multiple myeloma; bone marrow cell morphology; immuno fixation electrophoresis; serum free light chain |
| 基金项目: |
| Author Name | Affiliation | E-mail | | xiaofangzhang | Handan Central Hospital | zyxzxr666@126.com | | Yanqing Zhang | Clinical Laboratory, Handan Central Hospital, Handan 056000, China | | | Yungang Zhang | Clinical Laboratory, Handan Central Hospital, Handan 056000, China | | | Chuanke Wan | Clinical Laboratory, Handan Central Hospital, Handan 056000, China | | | Ling Xu | Clinical Laboratory, Handan Central Hospital, Handan 056000, China | | | Ruimin Li* | Clinical Laboratory, Handan Central Hospital, Handan 056000, China | |
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| 中文摘要: |
| 目的 探讨细胞形态特殊的IgD-?型多发性骨髓瘤（MM）的实验室指标变化特点，提高对IgD-?型MM的认知。方法 分析邯郸市中心医院2020年12月收治的1例IgD-?型MM患者的骨髓细胞形态、免疫固定电泳、血清游离轻链（sFLC）及流式细胞术检测指标。结果 患者骨髓涂片检查可见62%的异常细胞，该细胞可见成团分布，形态似淋巴瘤和转移癌细胞；免疫球蛋白IgG、IgA和IgM均低于正常范围，免疫固定电泳可见一条单克隆轻链?成分，血清游离轻链?为2700.00mg/L，游离轻链?/?为0.0023；血钙、乳酸脱氢酶（LDH）、?2微球蛋白升高；流式细胞术提示该细胞为浆细胞肿瘤等。结论 IgD-?型MM是一种少见类型的MM，其发病年龄小、侵袭性强、预后差，临床表现复杂，易误诊或漏诊。分析该病的临床症状、实验室特点，对疾病的诊断、治疗及预后都有积极作用。 |
| 英文摘要: |
| We aimed to explore the changes of laboratory indexes of IgD- λ type multiple myeloma with special cell
morphology, and to improve the cognition of IgD-λ type MM. To explore the changes of laboratory indexes
of IgD-λ type 1 multiple myeloma with special cell morphology, and to improve the cognition of IgD-λ
type MM. The morphology of bone marrow cells, immunofixation electrophoresis, serum free light chain
(sFLC) and other detection indexes of a patient with IgD-λ type MM treated in Handan Central Hospital in
December 2020 were analyzed. The patient bone marrow smears showed 62% of abnormal cells–which
were distributed in clusters and resembled lymphoma and metastatic cancer cells. The Flowcytometry
indicates that the cell is a plasma cell tumor.Immunoglobulin IgG, IgA and IgM were all lower than the
normal range.There is a monoclonal light chain λ component in immunofixation electrophoresis.The serum
free light chain λ was 2700.00 mg/ L, light chain k/λ is 0.0023, the high of serum calcium, LDH, β2
microglobulin. IgD-λ type MM is a rare type of MM. The age of onset is young, the invasiveness is strong,
the prognosis is poor, the clinical manifestation is complex, and it is easy to be misdiagnosed or missed.
The analysis of the clinical symptoms and laboratory characteristics of the disease plays a positive role in
the diagnosis, treatment and prognosis of the disease . |
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