| xiaofangzhang,Yanqing Zhang,Yungang Zhang,Chuanke Wan,Ling Xu,Ruimin Li. Special IgD-λ type multiple myeloma based on bone marrow cell morphology: A case report. Oncol Transl Med, 2021, 7: 239-241. |
| Special IgD-λ type multiple myeloma based on bone marrow cell morphology: A case report |
| Received:June 23, 2021 Revised:October 27, 2021 |
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| KeyWord:IgD-λ type multiple myeloma; bone marrow cell morphology; immuno fixation electrophoresis; serum free light chain |
| Author Name | Affiliation | E-mail | | xiaofangzhang | Handan Central Hospital | zyxzxr666@126.com | | Yanqing Zhang | Clinical Laboratory, Handan Central Hospital, Handan 056000, China | | | Yungang Zhang | Clinical Laboratory, Handan Central Hospital, Handan 056000, China | | | Chuanke Wan | Clinical Laboratory, Handan Central Hospital, Handan 056000, China | | | Ling Xu | Clinical Laboratory, Handan Central Hospital, Handan 056000, China | | | Ruimin Li | Clinical Laboratory, Handan Central Hospital, Handan 056000, China | |
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| Abstract: |
| We aimed to explore the changes of laboratory indexes of IgD- λ type multiple myeloma with special cell
morphology, and to improve the cognition of IgD-λ type MM. To explore the changes of laboratory indexes
of IgD-λ type 1 multiple myeloma with special cell morphology, and to improve the cognition of IgD-λ
type MM. The morphology of bone marrow cells, immunofixation electrophoresis, serum free light chain
(sFLC) and other detection indexes of a patient with IgD-λ type MM treated in Handan Central Hospital in
December 2020 were analyzed. The patient bone marrow smears showed 62% of abnormal cells–which
were distributed in clusters and resembled lymphoma and metastatic cancer cells. The Flowcytometry
indicates that the cell is a plasma cell tumor.Immunoglobulin IgG, IgA and IgM were all lower than the
normal range.There is a monoclonal light chain λ component in immunofixation electrophoresis.The serum
free light chain λ was 2700.00 mg/ L, light chain k/λ is 0.0023, the high of serum calcium, LDH, β2
microglobulin. IgD-λ type MM is a rare type of MM. The age of onset is young, the invasiveness is strong,
the prognosis is poor, the clinical manifestation is complex, and it is easy to be misdiagnosed or missed.
The analysis of the clinical symptoms and laboratory characteristics of the disease plays a positive role in
the diagnosis, treatment and prognosis of the disease . |
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