| Jiachen Zhang,Ting Wang,Siang Wei,Shujia Chen,Juan Bi. GFPT2 pan-cancer analysis and its prognostic and tumor microenvironment associations. Oncol Transl Med, 2021, 7: 286-293. |
| GFPT2 pan-cancer analysis and its prognostic and tumor microenvironment associations |
| Received:June 10, 2021 Revised:December 31, 2021 |
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| KeyWord:Glutamine fructose-6-phosphate transaminase 2 (GFPT2); pan-cancer, prognosis, immune, microenvironment |
| Author Name | Affiliation | Department | | Jiachen Zhang | The First Affiliated Hospital, Naval Medical University, Shanghai 200002, China | Department of Pharmacy | | Ting Wang | The First Affiliated Hospital, Naval Medical University, Shanghai 200002, China | Department of Pharmacy | | Siang Wei | The First Affiliated Hospital, Naval Medical University, Shanghai 200002, China | Department of Pharmacy, | | Shujia Chen | The First Affiliated Hospital, Naval Medical University, Shanghai 200002, China | Department of Pharmacy | | Juan Bi | The First Affiliated Hospital, Naval Medical University, Shanghai 200002, China | Department of Pharmacy |
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| Abstract: |
| Objective Glutamine fructose-6-phosphate transaminase 2 (GFPT2) is involved in a wide range of
biological functions in human cancer. However, few studies have comprehensively analyzed the correlation
between GFPT2 and different cancer prognoses and tumor microenvironments (TMEs).
Methods We evaluated the expression level and prognostic value of GFPT2 using updated public
databases and multiple comprehensive bioinformatics analysis methods and explored the relationship
between GFPT2 expression and immune infiltration, immune neoantigens, tumor mutational burden (TMB),
and microsatellite instability in pan-cancer.
Results GFPT2 was highly expressed in five cancers. GFPT2 expression correlates with the prognosis
of several cancers from The Cancer Genome Atlas (TCGA) and is significantly associated with stromal
and immune scores in pan-cancer. High GFPT2 expression in BLCA, BRCA, and CHOL was positively
correlated with the infiltration of immune cells, such as B-cells, CD4+ T, CD8+ T cells, dendritic cells,
neutrophils, and macrophages.
Conclusion High GFPT2 expression may modify the outcomes of patients with BLCA, BRCA, or CHOL
cancers by increasing immune cell infiltration. These findings may provide insights for further investigation
into GFPT2 as a potential target in pan-cancer. |
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