| Jiachen Zhang,Ting Wang,Siang Wei,Shujia Chen,Juan Bi. GFPT2 pan-cancer analysis and its prognostic and tumor microenvironment associations. Oncol Transl Med, 2021, 7: 286-293. |
| GFPT2在泛癌中与肿瘤微环境及预后的关系 |
| GFPT2 pan-cancer analysis and its prognostic and tumor microenvironment associations |
| Received:June 10, 2021 Revised:December 31, 2021 |
| DOI：10.1007/s10330-021-0500-0 |
| 中文关键词: GFPT2，膀胱癌，预后，免疫，微环境 |
| 英文关键词: Glutamine fructose-6-phosphate transaminase 2 (GFPT2); pan-cancer, prognosis, immune, microenvironment |
| 基金项目: |
| Author Name | Affiliation | Department | | Jiachen Zhang | The First Affiliated Hospital, Naval Medical University, Shanghai 200002, China | Department of Pharmacy | | Ting Wang | The First Affiliated Hospital, Naval Medical University, Shanghai 200002, China | Department of Pharmacy | | Siang Wei | The First Affiliated Hospital, Naval Medical University, Shanghai 200002, China | Department of Pharmacy, | | Shujia Chen | The First Affiliated Hospital, Naval Medical University, Shanghai 200002, China | Department of Pharmacy | | Juan Bi* | The First Affiliated Hospital, Naval Medical University, Shanghai 200002, China | Department of Pharmacy |
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| 中文摘要: |
| 目的 谷氨酰胺果糖-6-磷酸转氨酶2（GFPT2）参与人类癌症的广泛生物学功能。然而，很少有研究全面分析GFPT2与BLCA预后，肿瘤微环境（TME）之间的相关性。方法 根据更新的公共数据库和综合多种生物信息学分析方法，评估GFPT2基因的表达水平和预后价值，探讨GFPT2基因表达与BLCA免疫浸润的关系。结果 GFPT2在5种癌症中高表达。GFPT2表达与来自TCGA的几种癌症的预后相关。BLCA患者GFPT2基因表达低，随时间延长而显着下降（P<0.05），影响BLCA患者的生存时间。此外，BLCA中GFPT2的表达与免疫细胞如B细胞，CD4+T，CD8+T细胞，树突状细胞，嗜中性粒细胞和巨噬细胞的感染呈正相关。结论 GFPT2可作为BLCA的预后生物标志物，免疫微环境的变化在BLCA发生发展中起重要作用。 |
| 英文摘要: |
| Objective Glutamine fructose-6-phosphate transaminase 2 (GFPT2) is involved in a wide range of
biological functions in human cancer. However, few studies have comprehensively analyzed the correlation
between GFPT2 and different cancer prognoses and tumor microenvironments (TMEs).
Methods We evaluated the expression level and prognostic value of GFPT2 using updated public
databases and multiple comprehensive bioinformatics analysis methods and explored the relationship
between GFPT2 expression and immune infiltration, immune neoantigens, tumor mutational burden (TMB),
and microsatellite instability in pan-cancer.
Results GFPT2 was highly expressed in five cancers. GFPT2 expression correlates with the prognosis
of several cancers from The Cancer Genome Atlas (TCGA) and is significantly associated with stromal
and immune scores in pan-cancer. High GFPT2 expression in BLCA, BRCA, and CHOL was positively
correlated with the infiltration of immune cells, such as B-cells, CD4+ T, CD8+ T cells, dendritic cells,
neutrophils, and macrophages.
Conclusion High GFPT2 expression may modify the outcomes of patients with BLCA, BRCA, or CHOL
cancers by increasing immune cell infiltration. These findings may provide insights for further investigation
into GFPT2 as a potential target in pan-cancer. |
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