| Jiayu Du,Jie Tang,Qian Zhang,Xiaojie Ma. Cone beam computed tomography-guided differences among registration methods for lung cancer and the effects of tumor position, treatment model, and tumor size on positioning errors. Oncol Transl Med, 2021, 7: 203-208. |
| CBCT-guided differences in different registration methods for lung cancer and the effects of different tumor positions, treatment models, and tumor sizes on positioning errors |
| Cone beam computed tomography-guided differences among registration methods for lung cancer and the effects of tumor position, treatment model, and tumor size on positioning errors |
| Received:June 05, 2021 Revised:October 29, 2021 |
| DOI：10.1007/s10330-021-0499-9 |
| 中文关键词: lung cancer; IMRT; positioning error; registration method; CBCT; different tumor locations; different treatment modes; tumor size |
| 英文关键词: lung cancer; IMRT; positioning error; registration method; CBCT; different tumor locations; different treatment modes; tumor size |
| 基金项目:南德·拉亚德·考特（第18SXZ0542）），第二次大号（第11900002-037次）的 |
| Author Name | Affiliation | E-mail | | Jiayu Du | 北川医学院附属医院 | 1256357656@qq.com | | Jie Tang | Department of Oncology, Affiliated Hospital of North Sichuan Medical College | | | Qian Zhang | Department of Oncology, Affiliated Hospital of North Sichuan Medical College | | | Xiaojie Ma* | Department of Oncology, Affiliated Hospital of North Sichuan Medical College | 992437730@qq.com |
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| 中文摘要: |
| 摘要 目的：探讨锥型束CT（CBCT）引导下调强放射治疗（IMRT）肺癌三种不同配准方式的差异以及不同肿瘤位置、治疗模式及肿瘤大小对配准的影响。方法：回顾性分析2017年11月-2019年10月在我院放疗的80例肺癌患者，比较在自动骨性配准、自动灰度（t+r）配准和自动灰度（t）配准三种配准方式下X/Y/Z轴的摆位误差。同时将患者根据不同肿瘤位置、治疗模式、肿瘤大小进行分组进行摆位误差的比较。结果：患者在X/Y/Z轴上，自动灰度（t+r）配准和自动灰度（t）配准有更好的趋势；在不同治疗模式下，三种配准方式的差异均不显著；不同肿瘤大小在Y轴上，三种配准方式之间均有显著差异（p<0.05）；不同的肿瘤位置，在X/Y轴方向上的差异均不显著（p>0.05），而Z轴方向上自动骨性配准时纵隔肺门部的差异最大（p<0.05）。结论：治疗模式并不是影响肺癌配准误差的主要因素。在肺癌的配准中，对于上下肺<3cm的肿瘤，三种配准方式均可，更推荐采用自动灰度配准的方式；对于位于纵隔肺门部位<3cm的肿瘤以及上下肺>=3cm的肿瘤推荐采用灰度配准中的任一方式即可。 |
| 英文摘要: |
| Objective To explore the differences in three different registration methods of cone beam computed
tomography (CBCT)-guided down-regulated intense radiation therapy for lung cancer as well as the effects
of tumor location, treatment mode, and tumor size on registration.
Methods This retrospective analysis included 80 lung cancer patients undergoing radiotherapy in our
hospital from November 2017 to October 2019 and compared automatic bone registration, automatic
grayscale (t + r) registration, and automatic grayscale (t) positioning error on the X-, Y-, and Z-axes under
three types of registration methods. The patients were also grouped according to tumor position, treatment
mode, and tumor size to compare positioning errors.
Results On the X-, Y-, and Z-axes, automatic grayscale (t + r) and automatic grayscale (t) registration
showed a better trend. Analysis of the different treatment modes showed differences in the three registration
methods; however, these were not statistically significant. Analysis according to tumor sizes showed
significant differences between the three registration methods (P < 0.05). Analysis according to tumor
positions showed differences in the X- and Y-axes that were not significant (P > 0.05), while the autopsy
registration in the Z-axis showed the largest difference in the mediastinal and hilar lymph nodes (P < 0.05).
Conclusion The treatment mode was not the main factor affecting registration error in lung cancer. Three
registration methods are available for tumors in the upper and lower lungs measuring < 3 cm; among
these, automatic gray registration is recommended, while any gray registration method is recommended
for tumors located in the mediastinal hilar site measuring < 3 cm and in the upper and lower lungs ≥ 3 cm. |
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