| yuhangzhang,Peng Xu. Mechanism of tumor synthetic lethal-related targets. Oncol Transl Med, 2021, 7: 183-194. |
| Mechanism of tumor synthetic lethal-related targets |
| Mechanism of tumor synthetic lethal-related targets |
| Received:April 13, 2021 Revised:August 19, 2021 |
| DOI：10.1007/s10330-021-0490-0 |
| 中文关键词: 合成致死；靶向药物；常见肿瘤 |
| 英文关键词: synthetic lethal; targeted drug; common tumors |
| 基金项目:基于基因单核苷酸多态性研究卡培他滨所致手足综合征的中医体制分类 |
| Author Name | Affiliation | E-mail | | yuhangzhang | Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, China | 2289233936@qq.com | | Peng Xu* | Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi’an 710003, China | zxz310@163.com |
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| 中文摘要: |
| 合成致死在肿瘤学精准治疗中的地位越来越重要，基因突变所致的恶性肿瘤是一个复杂的DNA信号传导过程，从多方面抑制DNA信号可能更有效的控制肿瘤的发生发展。本文将在合成致死理论下探讨常见实体瘤的突变基因药物选择。 |
| 英文摘要: |
| Synthetic lethality is becoming more and more important in the precise treatment of oncology. Malignant
tumors caused by gene mutations involve a complex DNA signaling process, and inhibition of DNA signaling
in different ways may more effectively control the occurrence and development of tumors.
Inhibition of tumor paired lethal genes effectively kills tumor cells, and more and more novel drugs that
inhibit tumors are developing in this direction. This article reviews the synthetic lethal theory and discusses
selection of drugs to target mutated genes in common solid tumors. The synthetic lethal gene pairs,
representative targeted drugs, and related characteristics of four tumor types: lung cancer, breast cancer,
colon cancer and prostate cancer, are systematically reviewed. |
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