| Mengting Dong,Chunyang Li,Patiguli·Jiapaer,Xiaofei Li,Xiaohong Xue,Ke Jiang,Jiayu Sheng. KIF15 expression characteristics: Relevance toneo-adjuvant chemotherapy efficacy in breast cancer. Oncol Transl Med, 2021, 7: 69-75. |
| 乳腺癌组织中驱动蛋白KIF15的表达与新辅助化疗疗效的相关性 |
| KIF15 expression characteristics: Relevance toneo-adjuvant chemotherapy efficacy in breast cancer |
| Received:January 13, 2021 Revised:May 04, 2021 |
| DOI：10.1007/s10330-021-0478-8 |
| 中文关键词: 乳腺癌；新辅助化疗；驱动蛋白家族成员15；分子亚型 |
| 英文关键词: breast cancer; neoadjuvant chemotherapy; KIF15; molecular subtypes |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Mengting Dong | Department of Breast Diseases, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China | nancyd33@163.com | | Chunyang Li | Department of Breast Diseases, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China | | | Patiguli·Jiapaer | Department of Breast Diseases, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China | | | Xiaofei Li | Department of Breast Diseases, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China | | | Xiaohong Xue | Department of Breast Diseases, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China | | | Ke Jiang | Department of Breast Diseases, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China | | | Jiayu Sheng* | Department of Breast Diseases, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China | sjy1983sh@126.com |
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| 中文摘要: |
| 【摘要】目的 探讨乳腺癌驱动蛋白家族成员-15（kinesin family member15， KIF15）的表达与乳腺癌临床病理特征的相关性及其对新辅助化疗（neoadjuvant chemotherapy，NCT）疗效的影响，评价KIF15对新辅助化疗疗效的预测价值。方法 应用免疫组织化学方法检测93例行新辅助化疗的乳腺癌病例癌组织中KIF15的表达，分析其与新辅助化疗疗效及临床病理指标的关系。结果 ①KIF15在新辅助化疗前的高表达率为24.73%，KIF15表达与患者淋巴结转移、ER、HER-2及KI67表达情况呈正相关性（P<0.05）。②新辅助化疗的临床总有效率为70.97%，病理疗效评价为MHR比率达到61.29%，KIF15高表达组新辅助化疗临床有效率为95.65%，病理MHR比率为65.22%，明显高于KIF15低表达组（P<0.05）。③不同的分子分型与临床疗效及病理疗效也呈相关，其中有84%的TNBC患者评估为临床有效，52%的TNBC患者评估为病理疗效显著，明显高于其他分子分型（P<0.05）。④25例TNBC患者中KIF15表达与患者淋巴结转移情况及病理疗效呈正相关。结论 KIF15高表达者对化疗更为敏感，提示新辅助化疗疗效更好。不同分子分型患者新辅助化疗疗效不同，其中TNBC最好，且KIF15高表达的TNBC患者新辅助化疗疗效更优。可见，KIF15对乳腺癌新辅助化疗疗效具有一定的预测价值。 |
| 英文摘要: |
| Objective The relationship between the expression of kinesin family member 15 (KIF15) and
clinicopathological features in breast cancer (BC) remains controversial. In this study, we aimed to explore
the influence of KIF15 expression on the efficacy of neoadjuvant chemotherapy (NAC) and evaluate its
clinical value in predicting prognosis for BC patients.
Methods Immunohistochemistry was used to detect KIF15 expression in 93 BC patients undergoing
NAC to analyze the relationship between KIF15 expression and clinical efficacy and analytical parameters.
Results Of the 93 BC patients enrolled, 24.73% who underwent NAC had higher KIF15 expression levels,
showing positive correlations with ER, HER-2, Ki67, and lymph node metastasis (P < 0.05). The clinical
benefit of NAC was 70.97%, and the major histological response (MHR) rate was 61.29%. The effective
therapeutic rate in patients with high KIF15 expression was 95.65%, while the MHR rate was 65.22%.
Various molecular BC subtypes with varied clinical and pathological responses exhibited correlation to
a large extent. Of all the BC patients studied, 84% of the triple-negative breast cancer (TNBC) patients
were evaluated as clinically effective, and 52% of the TNBC patients were evaluated as pathologically
effective, and these values were significantly higher than those of the other molecular types (P < 0.05).
The expression of KIF15 in 25 TNBC patients showed positive correlations with lymph node metastasis.
Conclusion Overexpression of KIF15 was shown to increase BC sensitivity to chemotherapy and
demonstrated better outcomes. |
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