| Minhai Dong,Qungen Xiao,Jinyang Hu,Xiaopeng Li,Dongsheng Guo,Baofeng Wang. Meningeal melanocytoma in the cerebellopontine angle: A rare case report and review of the literature. Oncol Transl Med, 2021, 7: 35-40. |
| Meningeal melanocytoma in the cerebellopontine angle: A rare case report and review of the literature |
| Received:October 13, 2020 Revised:February 23, 2021 |
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| KeyWord:meningeal melanocytoma; cerebellopontine angle; pathology; therapy |
| Author Name | Affiliation | E-mail | | Minhai Dong | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | dongminhai@163.com | | Qungen Xiao | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Jinyang Hu | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Xiaopeng Li | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Dongsheng Guo | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Baofeng Wang | Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | wbf620@163.com |
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| Abstract: |
| Primary meningeal melanocytoma (MM) in the cerebellopontine angle (CPA) region is an extremely
rare neoplasm that originates from the melanocytes in the leptomeninges. These lesions are usually
misdiagnosed as they mimic other common CPA lesions through their nonspecific presenting symptoms,
signs, and radiological characteristics. Here, we report a 47-year-old Chinese female patient who
presented with a 1-month history of the right-sided tongue numbness and 1-week history of the rightsided face numbness that had been worsening for 2 days. The tumor, in the right CPA region, showed
a slight isointensity on T1-weighted image and mixed signal intensity on T2-weighted image. The
clinical presentation, surgical treatment, and pathologic characteristics were determined. The tumor was
microsurgically resected and gross-total resection was achieved. The tumor revealed a solid, capsulated,
brown-black lesion. Immunohistochemistry showed that the tumor cells were positive for human melanoma
black-45 (HMB-45), melanoma antigen (MelanA), S100, SOX10, and BRAF, confirming the final diagnosis
of meningeal melanocytoma. Ultimately, no signs of radiological local recurrence were observed during the
two-year follow-up. Collectively, meningeal melanocytoma is difficult to distinguish from common tumors in
the CPA region before operation due to the lack of specificity in imaging and symptoms. Complete surgical
resection is the best therapeutic option for this tumor. Although the tumor is commonly considered as a
benign lesion, recurrence and metastasis are common, and pathogenesis remains unclear. |
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