| Minhai Dong,Qungen Xiao,Jinyang Hu,Xiaopeng Li,Dongsheng Guo,Baofeng Wang. Meningeal melanocytoma in the cerebellopontine angle: A rare case report and review of the literature. Oncol Transl Med, 2021, 7: 35-40. |
| 脑膜黑素细胞瘤在桥小脑角区罕见：一例病例报告及文献复习 |
| Meningeal melanocytoma in the cerebellopontine angle: A rare case report and review of the literature |
| Received:October 13, 2020 Revised:February 23, 2021 |
| DOI：10.1007/s10330-020-0460-0 |
| 中文关键词: 脑膜黑素细胞瘤;桥小脑角;病理;治疗。 |
| 英文关键词: meningeal melanocytoma; cerebellopontine angle; pathology; therapy |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Minhai Dong | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | dongminhai@163.com | | Qungen Xiao | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Jinyang Hu | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Xiaopeng Li | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Dongsheng Guo | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Baofeng Wang* | Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | wbf620@163.com |
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| 中文摘要: |
| 原发性脑膜黑素细胞瘤（MM）是起源于软脑膜黑素细胞的肿瘤，该肿瘤在桥小脑角（CPA）区极为罕见。原发性脑膜黑素细胞瘤由于可表现出与其他常见的CPA病变类似的非特异性症状、体征和影像学特征，因此常被误诊。在此，我们报道了一名47岁的中国女性患者，主要表现为右侧舌头麻木1个月和右侧脸部麻木1周，加重2天。在T1加权图像上，右CPA区域的肿瘤显示出轻微的等信号，在T2加权图像上，显示混杂的信号。本文介绍了该患者的临床表现，手术治疗和病理特点，对该肿瘤进行显微手术切除，并实现了肿瘤全切除。该患者的肿瘤大体上呈实性，有包囊且呈棕黑色。免疫组织化学结果显示，人黑素瘤抗原-45（HMB-45），黑素瘤抗原（MelanA），S100，SOX10和BRAF在肿瘤细胞中呈阳性，该肿瘤最终诊断出脑膜黑素细胞瘤。两年后随访的影像学上未观察到局部肿瘤复发的迹象。总而言之，由于缺乏的特异性的影像学特征和症状，在手术前，脑膜黑素细胞瘤很难与CPA区域的常见肿瘤区分开。手术切除是该肿瘤的最佳治疗选择，尽管通常将肿瘤视为良性病变，但通常会发生复发和转移，而且发病机理仍不清楚。 |
| 英文摘要: |
| Primary meningeal melanocytoma (MM) in the cerebellopontine angle (CPA) region is an extremely
rare neoplasm that originates from the melanocytes in the leptomeninges. These lesions are usually
misdiagnosed as they mimic other common CPA lesions through their nonspecific presenting symptoms,
signs, and radiological characteristics. Here, we report a 47-year-old Chinese female patient who
presented with a 1-month history of the right-sided tongue numbness and 1-week history of the rightsided face numbness that had been worsening for 2 days. The tumor, in the right CPA region, showed
a slight isointensity on T1-weighted image and mixed signal intensity on T2-weighted image. The
clinical presentation, surgical treatment, and pathologic characteristics were determined. The tumor was
microsurgically resected and gross-total resection was achieved. The tumor revealed a solid, capsulated,
brown-black lesion. Immunohistochemistry showed that the tumor cells were positive for human melanoma
black-45 (HMB-45), melanoma antigen (MelanA), S100, SOX10, and BRAF, confirming the final diagnosis
of meningeal melanocytoma. Ultimately, no signs of radiological local recurrence were observed during the
two-year follow-up. Collectively, meningeal melanocytoma is difficult to distinguish from common tumors in
the CPA region before operation due to the lack of specificity in imaging and symptoms. Complete surgical
resection is the best therapeutic option for this tumor. Although the tumor is commonly considered as a
benign lesion, recurrence and metastasis are common, and pathogenesis remains unclear. |
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