| Zhuo Zhong,Fei Gao,Zhuo Lv,Zhi Hui Zhong,De Long. A case report of iodine-125 seed placement during operation for the treatment of advanced gallbladder carcinoma with septic shock. Oncol Transl Med, 2021, 7: 95-98. |
| 25I粒子植入治疗晚期胆囊癌术中感染性休克1例 |
| A case report of iodine-125 seed placement during operation for the treatment of advanced gallbladder carcinoma with septic shock |
| Received:September 25, 2020 Revised:April 08, 2021 |
| DOI：10.1007/s10330-020-0457-7 |
| 中文关键词: 晚期胆囊癌；125I粒子植入；脓毒血症；感染性休克 |
| 英文关键词: advanced gallbladder cancer; 125I seed placement; sepsis; septic shock |
| 基金项目:广州市花都区科技计划项目（20-HDWS-054） |
| Author Name | Affiliation | E-mail | | Zhuo Zhong | Department of Oncology, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou 510800, China | zhongzhuo36688@163.com | | Fei Gao | Department of Minimally Invasive Interventional Radiology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China | | | Zhuo Lv | Department of Oncology, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou 510800, China | | | Zhi Hui Zhong | Department of Minimally Invasive Interventional Radiology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China | | | De Long* | Department of Oncology, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou 510800, China | longted@163.com |
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| 中文摘要: |
| 本研究报道一例晚期胆囊癌患者，125I粒子植入术后感染性休克及治疗过程。中年女性晚期胆囊癌复发患者，接受125I粒子植入术治疗，术后出现脓毒血症伴感染性休克，血培养提示豚鼠气单胞菌和粪肠球菌感染，给予万古霉素、亚胺培南抗感染治疗，配合免疫球蛋白冲击及血管活性药物使用，病情逐渐稳定。125I粒子植入过程中，脓毒血症伴感染性休克非常罕见，一旦发生，患者死亡风险极大，广谱抗生素、免疫球蛋白和血管活性药物及时联合使用对稳定病情至关重要，本病例的治疗可作为临床医师处理此类并发症的参考。 |
| 英文摘要: |
| This case report describes a patient with advanced gallbladder cancer who developed septic shock
associated with iodine-125 (125I) seed implantation. The treatment process is described to provide a
clinical reference for similar cases. A 52-year-old woman with recurrence of advanced gallbladder cancer
underwent 125I seed implantation and developed postoperative sepsis with septic shock. The blood culture
suggested infection with Aeromonas caviae and Enterococcus faecalis. Vancomycin and imipenem were
immediately administered according to the drug sensitivity results, along with immunoglobulin therapy and
vasoactive drugs. The patient’s condition gradually stabilized after comprehensive treatment. Sepsis with
septic shock is a rare but potentially fatal complication of 125I seed implantation. Timely administration of
broad-spectrum antibiotics, immunoglobulin therapy, and vasoactive drugs is very important to stabilize
the patient’s condition. Our treatment of this patient can serve as a reference for clinicians to manage this
complication in similar cases. |
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