| Jian Li,Yimin Chen. Expression of PD-1/PD-L1 in lung adenocarcinoma and its clinical significance. Oncol Transl Med, 2021, 7: 15-19. |
| 四川省卫生适宜技术推广项目（2017YZ-00158） |
| Expression of PD-1/PD-L1 in lung adenocarcinoma and its clinical significance |
| Received:August 09, 2020 Revised:February 27, 2021 |
| DOI：10.1007/s10330-020-0449-9 |
| 中文关键词: 肺腺癌；PD-1；PD-L1；基因突变 |
| 英文关键词: lung adenocarcinoma; PD-1; PD-L1; gene mutation |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Jian Li* | Emeishan people''s Hospital | zhongzhonglw199@aliyun.com | | Yimin Chen | Department of Respiration, Emeishan People's Hospital, Emeishan 614200, China | |
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| 中文摘要: |
| 目的：探讨PD-1/PD-L1在非小细胞肺癌(NSCLC)中的表达及其临床意义。方法：选取100例肺腺癌患者为研究对象，检测手术标本组织中PD-1和PD-L1的表达，收集患者临床病理参数并随访，统计分析PD-1和PD-L1表达对肺腺癌患者临床病理参数及预后的影响。结果：（1）PD-L1和PD-1主要定位于肿瘤细胞的细胞膜和细胞浆。PD-1在肿瘤中的阳性表达率为53%，PD-L1在肿瘤中的阳性表达率为40%。（2）PD-1的表达对KRAS突变的发生率有明显影响（P＜0.05），PD-L1的表达对EGFR突变的发生率有明显影响（P＜0.05）。但PD-1/PD-L1表达对T分期、N分期、AJCC分期等临床病理特征无明显影响（P＞0.05）。（3）Kaplan-Meier生存分析显示，PD-1和PD-L1阳性表达对肺腺癌患者的DFS有显著的不良影响（2=14.52，P＜0.05；2=7.54，P＜0.05），PD-1和PD-L阳性患者的DFS较短，但二者对患者的OS无明显影响（2=2.74，P=0.152；2=1.63，P=0.405）。（4）COX多因素分析显示，EGFR基因突变、PD-1高表达、PD-L1高表达、N分期、AJCC分期均是影响患者DFS的独立性危险因素（P＜0.05）。结论：PD-1/PD-L1的高表达与肺腺癌的发生密切相关，且PD-L1的表达与EGFR突变、PD-1表达与KRAS突变状态之间呈负相关关系，可作为判断患者预后不良的独立性危险因素。 |
| 英文摘要: |
| Objective This study aimed to investigate PD-1/PD-L1 expression in lung adenocarcinoma and its
relationship with EGFR/KRAS mutation.
Methods The expression levels of PD-1 and PD-L1 in lung adenocarcinoma were detected.
Clinicopathological parameters were collected and followed up. The effects of PD-1 and PD-L1 expression
on clinicopathological parameters and prognosis of patients with lung adenocarcinoma were statistically
analyzed.
Results PD-L1 and PD-1 were mainly located in the membrane and cytoplasm of tumor cells. The
positive expression rates of PD-1 and PD-L1 were 53% and 40%, respectively. Positive PD-1 expression
had a significant effect on the incidence of KRAS mutation (P < 0.05), while PD-L1 expression significantly
affected the incidence of EGFR mutation (P < 0.05). Overexpression of PD-1 and PD-L1 had a significant
negative effect on disease-free survival (DFS) in patients with lung adenocarcinoma (P<0.05) but had no
significant effect on overall survival (P > 0.05). EGFR gene mutation, high PD-1 expression, high PD-L1
expression, N stage, and AJCC stage were independent risk factors of DFS (P < 0.05).
Conclusion High PD-1/PD-L1 expression is closely related to the occurrence of lung adenocarcinoma
and can be used as an independent factor to assess the prognosis of patients with lung adenocarcinoma.
There were negative correlations between PD-L1 expression and EGFR mutation and between PD-1
expression and KRAS mutation. |
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