| Min Li,Chengliang Zhang,Xiaofang Shangguan,Rui Huang,Dong Liu,Chengliang Zhang. Intervention for oxaliplatin-induced hypersensitivity in China: a cross-sectional internet-based survey. Oncol Transl Med, 2020, 6: 277-281. |
| 中国奥沙利铂所致过敏反应的干预现状：一项横断面网络调查 |
| Intervention for oxaliplatin-induced hypersensitivity in China: a cross-sectional internet-based survey |
| Received:June 28, 2020 Revised:December 04, 2020 |
| DOI：10.1007/s10330-020-0443-3 |
| 中文关键词: 奥沙利铂；过敏反应；干预；横断面 |
| 英文关键词: oxaliplatin; hypersensitivity reactions; intervention; cross-sectional survey |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Min Li | Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | 2254765273@qq.com | | Chengliang Zhang | Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | Yue Wang | Statistical Department, Tongji Hospital Affiliated with Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | Xiaofang Shangguan | School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | Rui Huang | School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | Dong Liu | Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | | Chengliang Zhang* | Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | clzhang@tjh.tjmu.edu.cn |
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| 中文摘要: |
| 摘要 目的 了解肿瘤医师对奥沙利铂（OXA）所致过敏反应的干预现状。方法 采用滚雪球抽样的方式通过网络向中国各省市从事肿瘤治疗的医师发放调查问卷，了解其社会人口学特征、OXA所致过敏反应的发生以及干预现状，运用假设性检验方法探析OXA过敏反应发生率与干预措施之间的关系。结果 共回收有效问卷401份，被调查者年龄主要分布在30~40岁且多数肿瘤医师工作年限不高于5年。使用糖皮质激素和H1受体拮抗剂预防OXA过敏反应的比例分别为67.83%和38.65%，且工作年限较长、职称较高的医师使用糖皮质激素预防比例较高，所报告的OXA过敏反应发生率较低。使用糖皮质激素类药物进行预防，可在一定程度上降低OXA过敏反应发生率（P<0.05）。结论 应增强低年资肿瘤医师预防OXA过敏反应的风险意识，并进一步促进糖皮质激素等预防OXA过敏反应的临床效果评价。 |
| 英文摘要: |
| Objective This cross-sectional study aimed at investigating the intervention status and the influence of
oncologists on oxaliplatin-induced hypersensitivity reactions (OIHR).
Methods Snowball sampling was used to send questionnaires to oncologists in various provinces and
cities in China, via the internet, to collect data on their socio-demographic characteristics, the occurrence
of OIHR, and the current status of interventions. One-way ANOVA and T-test of geographic samples were
used to explore the relationship between the incidence of OIHR and intervention measures.
Results A total of 401 valid questionnaires were collected, most respondents were 30–40 years old, and
most oncologists had 5 years of working experience. The proportions of glucocorticoid and H1 receptor
antagonist use for OIHR prevention were 67.83% and 38.65%, respectively. The proportion of oncologists
with longer working years and higher professional titles who used glucocorticoids for OIHR prevention was
higher, and the observed OIHR incidence was lower. Pretreatment with glucocorticoids may be an effective
preventive measure and can reduce the incidence of the OXA allergic reactions (P < 0.05).
Conclusion The risk awareness of junior oncologists to OIHR prevention should be strengthened, and
clinical efficacy evaluation of glucocorticoids in OIHR prevention should be further promoted. |
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