| Ying Li,Qiaofang Li,Yanluqi He,Hongzhen Zhang. The prognostic significance of ALI, PLR, and Ki-67 expression in stage III–IV inoperable non-small cell lung cancer. Oncol Transl Med, 2021, 7: 7-14. |
| The prognostic significance of ALI, PLR, and Ki-67 expression in stage III–IV inoperable non-small cell lung cancer |
| Received:June 23, 2020 Revised:February 19, 2021 |
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| KeyWord:non-small cell lung cancer (NSCLC); advanced lung cancer inflammation index (ALI); expression of Ki-67; prognosis |
| Author Name | Affiliation | E-mail | | Ying Li | 1.Graduate School of Hebei North University | 349546474@qq.com | | Qiaofang Li | 1.Graduate School of Hebei North University | | | Yanluqi He | 1.Graduate School of Hebei North University | | | Hongzhen Zhang | 1.Graduate School of Hebei North University | hongzhenzhang456@sohu.com |
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| Abstract: |
| Objective The aim of the study was to investigate and compare the prognostic value of advanced
inflammatory index, platelet/lymphocyte ratio (PLR), and Ki-67 expression in stage III–IV inoperable nonsmall cell lung cancer (NSCLC) before treatment.
Methods The clinical data of 98 inoperable patients with stage III–IV NSCLC in our hospital (Fifth
Department of Oncology, Hebei General Hospital, Shijiazhuang, China) before treatment were
retrospectively analyzed, and advanced lung cancer inflammation index (ALI) was calculated using body
mass index (BMI) × serum albumin (ALB) ÷ neutrophil/lymphocyte ratio (NLR). he optimal cutoff values of
ALI and PLR for predicting prognosis is determined. Chi-square test was used to analyze the relationship
between patients and clinical characteristics. Kaplan-Meier method was used to calculate the total survival
of patients, and log-rank test was used for comparison. Independent prognostic factors were assessed by
univariate and multivariate analyses. Spearman correlation was used to analyze the relationship among
ALI, PLR, and Ki-67.
Results In our study of the 98 cases, the survival time of the patients with ALI < 18 was significantly lower
than that of patients with ALI > 18 (P < 0.001), with a median survival time of 10 months and 25 months,
respectively. The survival time of patients with a PLR < 185 was significantly higher than that of patients
with a PLR > 185 (median survival time was 27 months vs. 10 months, P < 0.001).The higher the Ki-67
expression, the shorter the survival time (P < 0.005).The combined ALI and PLR detection results indicated
that the survival time of patients with high ALI and low PLR was significantly longer than that of patients with
low ALI and high PLR (P < 0.001). Univariate analysis showed that smoking history, degree of differentiation,
KPS score, Ki-67 expression, ALI value, and PLR affected the prognosis of patients. Multivariate analysis
showed that KPS score, ALI value, and Ki-67 expression were independent prognostic factors.
Conclusion ALI, PLR, and Ki-67 expression are important predictors of stage III-IV inoperable NSCLC.
In terms of the prognostic value, ALI seems to have the best ability to predict patient survival. In addition,
the combined detection of ALI and PLR levels before treatment seems to be more helpful in improving our
prediction of patient prognosis. Moreover, it is expected to play a role in future clinical applications. |
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