| Bowen Shi,Jianlong Bu,Yanbo Wang,Lantao Chen,Shidong Xu. Elevated pretreatment plasma fibrinogen level is associated with metastasis of non-small cell lung cancer (NSCLC). Oncol Transl Med, 2020, 6: 200-207. |
| 治疗前高水平血浆纤维蛋白原与非小细胞肺癌转移之间联系 |
| Elevated pretreatment plasma fibrinogen level is associated with metastasis of non-small cell lung cancer (NSCLC) |
| Received:May 19, 2020 Revised:October 16, 2020 |
| DOI：10.1007/s10330-020-0430-0 |
| 中文关键词: 纤维蛋白原；转移；非小细胞肺癌；肿瘤分期 |
| 英文关键词: fibrinogen; metastasis; NSCLC; tumor stage |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Bowen Shi | Department of Thoracic Surgery, Harbin Medical University Cancer Hospital | sbw1012@163.com | | Jianlong Bu | Department of Thoracic Surgery, Harbin Medical University Cancer Hospital | | | Yanbo Wang | Department of Thoracic Surgery, Harbin Medical University Cancer Hospital | | | Lantao Chen | Department of Thoracic Surgery, Harbin Medical University Cancer Hospital | | | Shidong Xu* | Department of Thoracic Surgery, Harbin Medical University Cancer Hospital | |
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| 中文摘要: |
| 目的：本研究主要目的在于探究患者治疗前血浆纤维蛋白原水平与非小细胞肺癌转移之间的联系。方法：本研究纳入了503例有明确病理诊断的非小细胞肺癌患者及168例有明确组织学诊断的良性肺部肿瘤患者。在患者进行治疗前评估患者血浆纤维蛋白原水平，并通过秩和检验、卡方检验等方法分析患者肿瘤大小、转移情况、临床分期与治疗前血浆纤维蛋白原之间联系。结果：伴有转移的非小细胞肺癌患者的血浆纤维蛋白原水平中位值高于不伴有转移非小细胞肺癌患者及肺部良性肿瘤患者的血浆纤维蛋白原中位值，并且差异具有统计学意义（秩和检验P<0.001）。血浆纤维蛋白原水平在进展期非小细胞肺癌患者中明显升高（秩和检验，P<0.001）。血浆纤维蛋白原升高（>2.974g/L）与非小细胞肺癌患者肿瘤的大小，转移及分期之间存在明显关联（卡方检验，P<0.001）。结论：通过此研究发现血浆纤维蛋白原水平升高可以用来评估非小细胞肺癌患者的转移及肿瘤进展情况。 |
| 英文摘要: |
| Objective The aim of this study was to investigate the correlation between pretreatment fibrinogen levels
and metastasis in non-small cell lung cancer (NSCLC).
Methods The study included 503 NSCLC patients with a clear pathological diagnosis and 168 patients
diagnosed with benign lung diseases by histological examination. Pretreatment plasma fibrinogen values
were quantified, and the relationship between plasma fibrinogen level and clinical variables comprising
tumor size, metastasis, and clinical stage was examined using Kruskal-Wallis test, Wilcoxon rank sum test,
and Chi-square test.
Results The median plasma fibrinogen values were statistically higher in NSCLC patients with metastasis
than patients with benign lung diseases and NSCLC patients without metastasis (Kruskal-Wallis test; P <
0.001). Plasma fibrinogen values were also significantly higher in advanced clinical stages (Wilcoxon rank
sum test; P < 0.001). A significant relationship was observed between elevated fibrinogen (> 2.974 g/L) and
metastasis, clinical stage, and tumor size (Chi-square test; P < 0.001).
Conclusion This correlation suggests that elevated pretreatment plasma fibrinogen levels can predict
metastasis and advanced tumor stage in NSCLC patients. |
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