| Jing Wang,Fei Liu,Yingying Wu,Lei Zhou,Guangyuan Hu,Lin Yang. Survival outcomes of patients with cervical esophageal cancer who received definitive radiotherapy: a retrospective study conducted in a single institution. Oncol Transl Med, 2020, 6: 135-142. |
| 颈段食管癌根治性放疗的生存预后：单中心回顾性研究 |
| Survival outcomes of patients with cervical esophageal cancer who received definitive radiotherapy: a retrospective study conducted in a single institution |
| Received:May 12, 2020 Revised:August 04, 2020 |
| DOI：10.1007/s10330-020-0428-8 |
| 中文关键词: 颈段食管癌，根治性放疗，生存预后 |
| 英文关键词: cervical esophageal cancer; definitive radiotherapy; survival outcomes |
| 基金项目: |
| Author Name | Affiliation | Postcode | | Jing Wang | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | 430030 | | Fei Liu | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Yingying Wu | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Lei Zhou | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Guangyuan Hu | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Lin Yang* | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | 430030 |
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| 中文摘要: |
| 目的 颈段食管癌（CEC）较少见，治疗经验有限。本研究的目的是为CEC行根治性放射治疗提供生存分析。
方法 回顾性分析2010年至2018年连续行根治性放疗的63例CEC患者的临床资料。对生存结果进行统计学分析。
结果 CEC中位无进展生存期（PFS）为12个月，总生存期（OS）为19个月。放射剂量≥60Gy组与<60Gy组的生存率无显著差异。有趣的是，对于近端亚组，与辐射剂量<60Gy组相比，辐射剂量≥60Gy组的PFS（p=0.039）、OS（p=0.031）和局部无复发生存率（LRFS）（p=0.005）显著提高。然而，远端亚组的改善并不显著。CEC放射治疗的安全性是可以接受的，放射剂量≥60Gy组与<60Gy组的毒性无显著性差异。
结论 CEC的生存率有待提高。对于近端CEC，辐射剂量≥60Gy与更好的PFS、OS和LRFS显著相关，值得进一步研究。 |
| 英文摘要: |
| Objective Cervical esophageal cancer (CEC) is a relatively rare condition, with limited treatment options.
The current study aimed to assess the survival outcomes of patients with CEC who received definitive
radiotherapy.
Methods In total, 63 consecutive patients with CEC who received definitive radiotherapy between 2010
and 2018 were included in this study. The survival outcomes were analyzed based on statistics.
Results The median progression-free survival (PFS) and overall survival (OS) of the patients were 12
and 19 months, respectively. There were no significant differences in terms of survival outcomes between
the groups who received radiation doses ≥ 60 and < 60 Gy. Interestingly, in the proximal CEC subgroup,
the PFS (P = 0.039), OS (P = 0.031), and loco-regional failure-free survival (LRFFS) (P = 0.005) improved
significantly in patients who received a radiation dose ≥ 60 Gy compared with those who received a
radiation dose < 60 Gy. However, in the distal CEC subgroup, the PFS, OS, and LRFFS did not significantly
improve between patients who received radiation doses ≥ 60 and < 60 Gy. Definitive radiotherapy was well
tolerated, and no significant differences were observed in terms of treatment-related toxicities between the
groups who received radiation doses ≥ 60 and < 60 Gy.
Conclusion The survival outcomes of patients with CEC should be improved. In proximal CEC, a radiation
dose ≥ 60 Gy is significantly correlated with better PFS, OS, and LRFFS. However, further research must
be performed to validate this finding. |
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