| Jing Wang,Fei Liu,Yingying Wu,Lei Zhou,Guangyuan Hu,Lin Yang. Survival outcomes of patients with cervical esophageal cancer who received definitive radiotherapy: a retrospective study conducted in a single institution. Oncol Transl Med, 2020, 6: 135-142. |
| Survival outcomes of patients with cervical esophageal cancer who received definitive radiotherapy: a retrospective study conducted in a single institution |
| Received:May 12, 2020 Revised:August 04, 2020 |
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| KeyWord:cervical esophageal cancer; definitive radiotherapy; survival outcomes |
| Author Name | Affiliation | Postcode | | Jing Wang | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | 430030 | | Fei Liu | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Yingying Wu | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Lei Zhou | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Guangyuan Hu | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Lin Yang | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | 430030 |
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| Abstract: |
| Objective Cervical esophageal cancer (CEC) is a relatively rare condition, with limited treatment options.
The current study aimed to assess the survival outcomes of patients with CEC who received definitive
radiotherapy.
Methods In total, 63 consecutive patients with CEC who received definitive radiotherapy between 2010
and 2018 were included in this study. The survival outcomes were analyzed based on statistics.
Results The median progression-free survival (PFS) and overall survival (OS) of the patients were 12
and 19 months, respectively. There were no significant differences in terms of survival outcomes between
the groups who received radiation doses ≥ 60 and < 60 Gy. Interestingly, in the proximal CEC subgroup,
the PFS (P = 0.039), OS (P = 0.031), and loco-regional failure-free survival (LRFFS) (P = 0.005) improved
significantly in patients who received a radiation dose ≥ 60 Gy compared with those who received a
radiation dose < 60 Gy. However, in the distal CEC subgroup, the PFS, OS, and LRFFS did not significantly
improve between patients who received radiation doses ≥ 60 and < 60 Gy. Definitive radiotherapy was well
tolerated, and no significant differences were observed in terms of treatment-related toxicities between the
groups who received radiation doses ≥ 60 and < 60 Gy.
Conclusion The survival outcomes of patients with CEC should be improved. In proximal CEC, a radiation
dose ≥ 60 Gy is significantly correlated with better PFS, OS, and LRFFS. However, further research must
be performed to validate this finding. |
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