| Yang Tang,Li Yang,Wan Qin,Minxiao Yi,Bo Liu,Xianglin Yuan. A missense variant of MASP2 is associated with increased risk of radiation pneumonitis in lung cancer patients treated with radiation therapy. Oncol Transl Med, 2020, 6: 193-199. |
| MASP2的单核苷酸多态位点的错意突变与放射性肺炎相关性研究 |
| A missense variant of MASP2 is associated with increased risk of radiation pneumonitis in lung cancer patients treated with radiation therapy |
| Received:May 07, 2020 Revised:September 01, 2020 |
| DOI：10.1007/s10330-020-0425-5 |
| 中文关键词: 放射性肺炎、肺癌、MASP2、单核苷酸多态性 |
| 英文关键词: radiation pneumonitis; lung cancer; mannan-binding lectin-associated serine protease 2 (MASP2); Single Nucleotide Polymorphisms (SNP) |
| 基金项目:该研究由中国国家自然科学基金资助(编号81773360 和81700145) |
| Author Name | Affiliation | E-mail | | Yang Tang | Tongji Hospital affiliated with Tongji Medical College, Huazhong University of Science and Technology, Hankou District, Wuhan, Hubei Province, China | tangyangtjmu@126.com | | Li Yang | Tongji Hospital affiliated with Tongji Medical College, Huazhong University of Science and Technology, Hankou District, Wuhan, Hubei Province, China | | | Wan Qin | Tongji Hospital affiliated with Tongji Medical College, Huazhong University of Science and Technology, Hankou District, Wuhan, Hubei Province, China | | | Minxiao Yi | Tongji Hospital affiliated with Tongji Medical College, Huazhong University of Science and Technology, Hankou District, Wuhan, Hubei Province, China | | | Bo Liu | Tongji Hospital affiliated with Tongji Medical College, Huazhong University of Science and Technology, Hankou District, Wuhan, Hubei Province, China | | | Xianglin Yuan* | Tongji Hospital affiliated with Tongji Medical College, Huazhong University of Science and Technology, Hankou District, Wuhan, Hubei Province, China | |
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| 中文摘要: |
| 目的：放射性肺炎是胸部肿瘤放疗后常见并发症之一，其具体机制不明。MASP2作为补体系统中的重要部分，被认为在炎症损伤中具有重要作用。然而MASP2在放射性肺炎中的作用尚无人研究。本研究旨在通过关联分析来研究MASP2单核苷酸基因多态性与放射性肺炎发病风险的关系。
方法：本前瞻性临床研究（NCT02490319）纳入169例行胸部放疗的肺癌患者。获取其相关临床特征、随访资料和体细胞DNA。并使用Sanger测序对169例患者进行体细胞DNA分型分析。使用多因素Cox分析和Kaplan-Meier关联分析分析临床因素、放射剂量因素与MASP2位点对放射性肺炎发病风险的影响。
结果：本研究发现MLD（平均肺体积）≥ 15Gy和V20（照射剂量大于等于20Gy的肺体积比例）≥ 24%有更高的中重度放射性肺炎发生风险(HR=1.888, 95% CI: 1.186-3.004, P=0.007; HR=2.126, 95% CI: 1.338-3.378, P=0.001)。MASP2: rs12711521与 ≥ 2级放射性肺炎显著相关(HR=1.949, 95% CI: 1.278-2.971, P=0.002)。
结论：我们的队列中发现MLD、V20和MASP2: rs12711521与 ≥ 2级放射性肺炎发生风险显著相关。MASP2: rs12711521基因型是独立于MLD或V20的危险因素。若该研究成果被多中心大样本研究证实，则可能在成为放射治疗前预测中重度放射性肺炎发生的重要标志物。 |
| 英文摘要: |
| Objective In this study, mannan-binding lectin-associated serine protease 2 (MASP2) gene variant was
evaluated to assess the risk of radiation pneumonitis (RP) in patients with pulmonary malignancies.
Methods A total of 169 lung cancer patients with radiotherapy were included in our prospective study
(NCT02490319) and genotyped using the Sanger sequencing method. Multivariate Cox hazards analysis
and multiple testing were applied to estimate the hazard ratio (HR) and 95% confidence intervals (CIs) of
all factors possibly associated with RP risk.
Results?Patients?with?mean?lung?disease?≥?15?Gy?and?V 20 ?≥?24%?had?higher?risk?of?RP?≥?grade?2
compared with their counterparts (HR = 1.888, 95% CI: 1.186–3.004, P = 0.007; HR = 2.126, 95% CI:
1.338–3.378, P = 0.001, respectively). Importantly, CC + CA genotype of MASP2: rs12711521 was strongly
associated?with?an?increased?occurrence?of?RP?≥?grade?2?(HR?=?1.949,?95%?CI:?1.278–2.971,?P = 0.002).
Conclusion MASP2: rs12711521?was?found?to?be?significantly?associated?with?RP?≥?grade?2?in?our?cohort
and may thus be one of the important predictors of severe RP before radiotherapy, if further validated in
larger population. |
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