| Yanlin Feng,Souraka Tapara Dramani Maman,Shuo Li,Dingdong He,Jiancheng Tu. Link between miR-19b and the mTOR signaling pathway in cancer prognosis. Oncol Transl Med, 2020, 6: 153-164. |
| miR-19b与mTOR信号通路在肿瘤预后中的作用 |
| Link between miR-19b and the mTOR signaling pathway in cancer prognosis |
| Received:April 23, 2020 Revised:May 15, 2020 |
| DOI：10.1007/s10330-020-0422-2 |
| 中文关键词: 微小RNA；miR-19b；预后；机制；mTOR；癌症 |
| 英文关键词: microRNA; miR-19b; prognosis; mechanism; mTOR; cancers |
| 基金项目:武汉大学中南医院科研种子培养计划（cxpy2018067）；武汉大学中南医院科研种子培养计划（ZNPY2017054） |
| Author Name | Affiliation | E-mail | | Yanlin Feng | Department of Clinical Laboratory Medicine & Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China | yanlinfeng@whu.edu.cn | | Souraka Tapara Dramani Maman | Department of Clinical Laboratory Medicine & Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China | | | Shuo Li | Department of Clinical Laboratory Medicine & Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China | | | Dingdong He | Department of Clinical Laboratory Medicine & Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China | | | Jiancheng Tu* | Department of Clinical Laboratory Medicine & Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China | jianchengtu@whu.edu.cn |
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| 中文摘要: |
| 关于miR-19b对肿瘤预后的作用，以往的研究存在明显的分歧和矛盾。同时，miR-19b可通过不同的途径影响肿瘤生长，主要靶向PTEN-PI3K-AKT从而激活下游mTOR通路。为了探讨miR-19b与mTOR可能存在的联系对癌症预后的影响，我们对已发表的文献进行了全面的总结。结果显示miR-19b的高表达可通过促进癌症的远处转移从而缩短患者的总体生存期（HRs = 1.54，95% CIs = 1.20-1.98），但其对患者的无病生存期及无进展生存期没有影响（HRs = 0.61，95% CIs = 0.31-1.19）；对TCGA数据库数据的分析结果也证明了miR-19b在肿瘤发生发展中的作用。进一步的试验序列分析表明，尽管目前结果认为miR-19b对患者的无病生存期及无进展生存期没有影响，但仍需通过增加纳入的文献量来证明这一结论。同时通过对miR-19b参与癌症进展机制的探讨，揭示了miR-19b与mTOR通路可能的关联，miR-19b可能通过mTOR通路发挥其促癌作用，其可能成为肿瘤的治疗靶点。 |
| 英文摘要: |
| Objective Previous studies have reported differing conclusions regarding the prognostic value of miR-
19b in cancers. Moreover, miR-19b may affect tumor growth by different pathways, mainly targeting PTENPI3K-
AKT, which activates the downstream mTOR pathway. Therefore, we performed data mining to
explore the possible correlation between miR-19b and mTOR in cancer prognosis.
Methods We conducted online search and collected a total of 943 articles. According to different authors
cross check and our study including/excluding criteria we at end retained 21 articles with 25 studies in this
meta-analysis. Then TCGA data containing miR-19b level with cancer progression were obtained using
OncomiR. Furthermore, Trial Sequential Analysis (TSA) was performed to determine whether the results of
our meta-analysis could be used in clinical applications. After that, articles regarding the mechanism of miR-
19b in various cancers were analyzed and KEGG pathway database was used to find the main regulatory
function of miR-19b in human cancers.
Results Overall hazard ratio (HR) results showed that higher levels of miR-19b expression were
correlated with shorter overall survival time [HR = 1.54, 95% confidence interval (CI) = 1.20-1.98] by
promoting distant metastasis, but had no correlation with disease-free survival (DFS)/progression-free
survival (PFS; HR = 0.61, 95% CI = 0.31–1.19). Data from The Cancer Genome Atlas also revealed the
role of miR-19b in tumorigenesis. According to trial sequential analysis results, more evidence is required
to confirm that miR-19b is not correlated with DFS/PFS. Exploration of the mechanism revealed a possible
link between miR-19b and the mTOR pathway.
Conclusion miR-19b may have a pro-carcinogenic role through the mTOR pathway and thus, it is likely
to be a therapeutic target for cancers. |
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