| Yakun He,Min Wang,Heping Deng,Jin Ren. Application of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) combined with magnetic resonance spectroscopy (MRS) in prostate cancer diagnosis. Oncol Transl Med, 2021, 7: 31-34. |
| 磁共振动态增强扫描联合波谱分析在前列腺癌诊断中的价值 |
| Application of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) combined with magnetic resonance spectroscopy (MRS) in prostate cancer diagnosis |
| Received:March 27, 2020 Revised:January 27, 2021 |
| DOI：10.1007/s10330-020-0414-4 |
| 中文关键词: 前列腺癌；磁共振成像；动态增强；波谱成像 |
| 英文关键词: prostate cancer; magnetic resonance imaging (MRI); dynamic contrast-enhanced (DCE); spectroscopy |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Yakun He | Department of Radiology, Sichuan Cancer Hospital, Chengdu 610041, China | hykun_1123@163.com | | Min Wang* | Department of Radiology, Sichuan Cancer Hospital, Chengdu 610041, China | 273795600@qq.com | | Heping Deng | Department of Radiology, Sichuan Cancer Hospital, Chengdu 610041, China | | | Jin Ren | Department of Radiology, Sichuan Cancer Hospital, Chengdu 610041, China | |
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| 中文摘要: |
| 目的：探讨磁共振动态增强扫描联合波谱分析在前列腺癌诊断中的价值。方法：在我院门诊部从2013年1月至2017年1月所诊断为前列腺疾病患者中随机抽取前列腺癌确诊患者60名，前列腺增生患者60名，健康体检者60名，并依次将他们列入前列腺癌组、增生组及对照组。使用SiemensAvanto1.5 T高场强超导MR成像仪，进行DCE-MRI扫描及MRS扫描，MRS扫描完毕后，在工作站spectroscopy选项卡进行频谱分析，生成前列腺代谢产物胆碱(Cho)、肌酸(Cr)和枸椽酸盐(Cit)的波峰谱线，并计算出Cho/Cit、(Cho+Cr)/Cit的比值及均值。结果：三组研究对象在21sec、1 min、2 min所进行的MR动态增强检查结果之间的比较具有统计学意义，检查存在着显著性的差异。三组研究对象所进行的波谱分析结果之间的比较具有统计学意义，检查存在着显著性的差异。DCE-MRI和MRS两种检查方法的联合应用敏感性为89.67%，特异性为95.78％,准确性为94.34%。结论：DCE-MRI联合MRS检查在前列腺癌的诊断中是有应用价值的。 |
| 英文摘要: |
| Objective The aim of the study was to investigate the application of dynamic contrast-enhanced magnetic
resonance imaging (DCE-MRI) combined with magnetic resonance spectroscopy (MRS) in prostate cancer
diagnosis.
Methods In the outpatient department of our hospital (Sichuan Cancer Hospital, Chengdu, China), 60
patients diagnosed with prostate disease were selected randomly and included in a prostate cancer group,
60 patients with benign prostatic hyperplasia were included in a proliferation group, and 60 healthy subjects
were included in a control group, from January 2013 to January 2017. Using Siemens Avanto 1.5 T highfield superconducting MRI for DCE-MRI and MRS scans, after the MRS scan was completed, we used
the workstation spectroscopy tab spectral analysis, and eventually obtained the crest lines of the prostate
metabolites choline (Cho), creatine (Cr), citrate (Cit), and the values of Cho/Cit, and (Cho + Cr)/Cit.
Results Participants who had undergone 21-s, 1-min, and 2-min dynamic contrast-enhanced MR
revealed significant variations among the three groups. The spectral analysis of the three groups revealed
a significant variation as well. DCE-MRI and MRS combined had a sensitivity of 89.67%, specificity of
95.78%, and accuracy of 94.34%.
Conclusion DCE-MRI combined with MRS is of great value in the diagnosis of prostate cancer |
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