| Xiaoying Quan,Zhihui Zhang. A case report of double-protein expression in primary uterine cervical diffuse large B cell lymphoma and a review of the literature. Oncol Transl Med, 2020, 6: 131-133. |
| A case report of double-protein expression in primary uterine cervical diffuse large B cell lymphoma and a review of the literature |
| Received:March 12, 2020 Revised:June 14, 2020 |
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| KeyWord:diffuse large B-cell lymphoma; uterine cervix; “double-protein” expression |
| Author Name | Affiliation | E-mail | | Xiaoying Quan | The Sixth People''s Hospital of Chengdu | 1193084163@qq.com | | Zhihui Zhang | Department of Lymphoma, Sichuan Cancer Hospital and Research Institute, Chengdu 610041, China | |
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| Abstract: |
| Primary non-Hodgkin’s lymphoma of the uterine cervix is rarely observed. Here, we report a case of “doubleprotein” expression in a primary uterine cervical diffuse large B-cell lymphoma that was detected based on
cervical biopsies at Sichuan Cancer Hospital in December 2016 in a 53-year-old woman with a 1-month
history of postmenopausal vaginal bleeding. She was diagnosed with stage IVA cervical cancer after workup
and treated with six cycles of rituximab + cyclophosphamide + epirubicin + vindesine + prednisone. She
showed a positive partial response after two cycles; however, response assessment revealed a progressive
disease after six cycles. Based on the current condition, a treatment regimen comprising a combination of
second-line chemotherapy and radiotherapy was advised for the patient. Unfortunately, she discontinued
her treatment because of various factors. We conclude that “double-protein” expression in primary uterine
cervical diffuse large B-cell lymphoma is difficult to treat and has a poor prognosis. Therefore, improving the
diagnosis and treatment of this disease should be considered. |
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