| Xiaoying Quan,Zhihui Zhang. A case report of double-protein expression in primary uterine cervical diffuse large B cell lymphoma and a review of the literature. Oncol Transl Med, 2020, 6: 131-133. |
| 原发性子宫颈弥漫大B细胞淋巴瘤“双蛋白表达”1例 |
| A case report of double-protein expression in primary uterine cervical diffuse large B cell lymphoma and a review of the literature |
| Received:March 12, 2020 Revised:June 14, 2020 |
| DOI：10.1007/s10330-020-0409-9 |
| 中文关键词: ：弥漫大B细胞淋巴瘤；子宫颈癌；“双蛋白表达” |
| 英文关键词: diffuse large B-cell lymphoma; uterine cervix; “double-protein” expression |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Xiaoying Quan* | The Sixth People''s Hospital of Chengdu | 1193084163@qq.com | | Zhihui Zhang | Department of Lymphoma, Sichuan Cancer Hospital and Research Institute, Chengdu 610041, China | |
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| 中文摘要: |
| 子宫颈原发性非霍奇金淋巴瘤罕见。我们在此报告一例2016年12月于四川肿瘤医院行宫颈活检的原发性子宫颈弥漫性大B细胞淋巴瘤中“双蛋白表达”病例，该病例发生于一名53岁妇女，有绝经后阴道出血1个月的病史。经过检查，她被诊断为IVA期，并接受了6个周期的RCHOP治疗(利妥昔单抗+环磷酰胺+表柔比星+长春新碱+强的松)。2周期化疗后为部分缓解，但6周期化疗后为进展。随调整化疗方案为“西达本胺 +顺铂+异环磷酰胺+地塞米松+依托泊苷”，最终因患者无法耐受化疗副作用而放弃治疗出院。我们的结论是，“双蛋白表达”在原发性子宫颈弥漫性大B细胞淋巴瘤中的表达是难以治疗和预后不良的。因此，应考虑提高诊断和治疗。 |
| 英文摘要: |
| Primary non-Hodgkin’s lymphoma of the uterine cervix is rarely observed. Here, we report a case of “doubleprotein” expression in a primary uterine cervical diffuse large B-cell lymphoma that was detected based on
cervical biopsies at Sichuan Cancer Hospital in December 2016 in a 53-year-old woman with a 1-month
history of postmenopausal vaginal bleeding. She was diagnosed with stage IVA cervical cancer after workup
and treated with six cycles of rituximab + cyclophosphamide + epirubicin + vindesine + prednisone. She
showed a positive partial response after two cycles; however, response assessment revealed a progressive
disease after six cycles. Based on the current condition, a treatment regimen comprising a combination of
second-line chemotherapy and radiotherapy was advised for the patient. Unfortunately, she discontinued
her treatment because of various factors. We conclude that “double-protein” expression in primary uterine
cervical diffuse large B-cell lymphoma is difficult to treat and has a poor prognosis. Therefore, improving the
diagnosis and treatment of this disease should be considered. |
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