| Ying Shao,Yadi Wang,Fuli Zhang,Shi Wang. Application of biological optimization of hypofractionated radiotherapy post conservative surgery for breast cancer. Oncol Transl Med, 2020, 6: 93-97. |
| 生物优化方法在乳腺癌保乳术后低分割放疗中的应用 |
| Application of biological optimization of hypofractionated radiotherapy post conservative surgery for breast cancer |
| Received:January 26, 2020 Revised:June 21, 2020 |
| DOI：10.1007/s10330-020-0404-4 |
| 中文关键词: 等效均匀剂量; 乳腺癌; 低分割放疗; 剂量学 |
| 英文关键词: equivalent uniform dose (EUD); breast cancer; hypofractionated radiotherapy; dosimetry |
| 基金项目:北京市科技计划项目（编号：Z181100001718011） |
| Author Name | Affiliation | Postcode | | Ying Shao | Department of Radiotherapy, Beijing Tsinghua Changgung Hospital affiliated to Tsinghua University | 102218 | | Yadi Wang | Department of Radiotherapy, The Seventh Medical Center, PLA General Hospital | | | Fuli Zhang* | Department of Radiotherapy, The Seventh Medical Center, PLA General Hospital | | | Shi Wang | Department of Engineering Physics, Tsinghua University | |
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| 中文摘要: |
| 目的：探讨乳腺癌保守术后低分割放疗中生物学优化方法的应用及其与物理优化方法的差异。方法：回顾性研究15例已接受放疗的左侧乳腺癌患者。对每一例患者，选用容积旋转调强放疗技术（VMAT）重新设计四组放疗计划，分别为物理优化组（PF组）、生物-物理优化组合组（BF + PF组和PF + BF组）和生物优化组（BF组）。通过计算和分析相应的剂量-体积参数，评估基于以上四种优化方法的剂量学差异。结果：除CI外，BF组计划与PF组计划的靶区参数差异有统计学意义（P<0.05）。 BF组和BF + PF组的TCP值均高于PF组和PF + BF组。此外，BF组患侧肺的剂量-体积参数明显小于其他三组计划，MU数也分别比PF组和PF + BF组降低约16％。结论：生物优化方法有助于提高靶区的EUD和TCP值，同时降低危及器官的剂量-体积参数并提高了治疗实施效率。 |
| 英文摘要: |
| Objective The aim of the study was to discuss the application of biological optimization and its difference
from physical optimization in hypofractionated radiotherapy for breast cancer after conservative surgery.
Methods This retrospective study enrolled 15 randomly chosen patients with left-sided breast cancer
who received radiotherapy. The volumetric arc therapy (VMAT) technique was used to redesign treatment
plans with physical functions (PF) group, biological-physical functions combined (BF + PF and PF + BF)
groups, and biological functions (BF) group. The dosimetric differences based on the above four optimization
methods were assessed by calculating and analyzing the corresponding dose-volume parameters.
Results The target parameters of the four groups differed significantly (P < 0.05) except for the conformity
index (CI). The tumor control probability (TCP) values in the BF and BF + PF groups were higher than those
in the PF and PF + BF groups. Moreover, the dose-volume parameters of the ipsilateral lung in the BF group
were less than those of three other groups, while the monitor unit (MU) in the BF group was approximately
16% lower than those of the PF and PF + BF groups.
Conclusion Biological functions were useful to increase the equivalent uniform dose (EUD) and TCP
values of the target, decrease the dose-volume parameters of the organs-at-risk (OARs), and improve
treatment efficiency |
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