| Ying Shao,Yadi Wang,Fuli Zhang,Shi Wang. Application of biological optimization of hypofractionated radiotherapy post conservative surgery for breast cancer. Oncol Transl Med, 2020, 6: 93-97. |
| Application of biological optimization of hypofractionated radiotherapy post conservative surgery for breast cancer |
| Received:January 26, 2020 Revised:June 21, 2020 |
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| KeyWord:equivalent uniform dose (EUD); breast cancer; hypofractionated radiotherapy; dosimetry |
| Author Name | Affiliation | Postcode | | Ying Shao | Department of Radiotherapy, Beijing Tsinghua Changgung Hospital affiliated to Tsinghua University | 102218 | | Yadi Wang | Department of Radiotherapy, The Seventh Medical Center, PLA General Hospital | | | Fuli Zhang | Department of Radiotherapy, The Seventh Medical Center, PLA General Hospital | | | Shi Wang | Department of Engineering Physics, Tsinghua University | |
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| Abstract: |
| Objective The aim of the study was to discuss the application of biological optimization and its difference
from physical optimization in hypofractionated radiotherapy for breast cancer after conservative surgery.
Methods This retrospective study enrolled 15 randomly chosen patients with left-sided breast cancer
who received radiotherapy. The volumetric arc therapy (VMAT) technique was used to redesign treatment
plans with physical functions (PF) group, biological-physical functions combined (BF + PF and PF + BF)
groups, and biological functions (BF) group. The dosimetric differences based on the above four optimization
methods were assessed by calculating and analyzing the corresponding dose-volume parameters.
Results The target parameters of the four groups differed significantly (P < 0.05) except for the conformity
index (CI). The tumor control probability (TCP) values in the BF and BF + PF groups were higher than those
in the PF and PF + BF groups. Moreover, the dose-volume parameters of the ipsilateral lung in the BF group
were less than those of three other groups, while the monitor unit (MU) in the BF group was approximately
16% lower than those of the PF and PF + BF groups.
Conclusion Biological functions were useful to increase the equivalent uniform dose (EUD) and TCP
values of the target, decrease the dose-volume parameters of the organs-at-risk (OARs), and improve
treatment efficiency |
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