| Shaojun Nong,Yangbo Guan,Zhongqing Wei#,Yueping Zhang,Bin Cheng,Chongsheng He,Limin Ma,Shujun Zhou,Wenguang Li,Jian Ni,Zhiwei Wang. Title:Impact of IL-18 gene promoter polymorphisms on renal cell carcinoma occurrence and prognosis in Han Chinese population. Oncol Transl Med, 2019, 5: 278-284. |
| Title:Impact of IL-18 gene promoter polymorphisms on renal cell carcinoma occurrence and prognosis in Han Chinese population |
| Received:December 11, 2019 Revised:January 04, 2020 |
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| KeyWord:Interleukin-18; renal cell carcinoma; Polymorphism; Prognosis |
| Author Name | Affiliation | E-mail | | Shaojun Nong | Department of Urological Surgery,The Affiliated Hospital of Nantong University | shaojunnong@sina.com | | Yangbo Guan | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Zhongqing Wei# | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Yueping Zhang | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Bin Cheng | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Chongsheng He | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Limin Ma | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Shujun Zhou | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Wenguang Li | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Jian Ni | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Zhiwei Wang | Department of Urological Surgery,The Affiliated Hospital of Nantong University | |
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| Abstract: |
| Objective This study was to examine a possible association between two promoter polymorphisms, -137G/C and -607C/A, in the IL-18 gene and renal cell carcinoma occurrence and prognosis in Han Chinese.
Methods We used a high-resolution melting method to genotype these two polymorphisms in 175 Chinese Han patients with renal cell carcinoma enrolled to follow-up in this study and in 200 age-matched healthy controls.
Result Carriers of the GG genotype of the -137G/ C polymorphism had 2.165 time higher risk of renal cell carcinoma progression than carriers of GC[HR=2.15, 95%CI=1.270-3.687]. However, we found no significant association of genotype or allele distributions of these two polymorphisms with occurrence of renal cell carcinoma.
Conclusion We conclude that there is evidence that the IL-18 gene promoter polymorphism -137G/C influences the prognosis of renal cell carcinoma patients. |
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