| Shaojun Nong,Yangbo Guan,Zhongqing Wei#,Yueping Zhang,Bin Cheng,Chongsheng He,Limin Ma,Shujun Zhou,Wenguang Li,Jian Ni,Zhiwei Wang. Title:Impact of IL-18 gene promoter polymorphisms on renal cell carcinoma occurrence and prognosis in Han Chinese population. Oncol Transl Med, 2019, 5: 278-284. |
| 白细胞介素18启动子基因多态性在中国汉族肾癌复发及预后影响 |
| Title:Impact of IL-18 gene promoter polymorphisms on renal cell carcinoma occurrence and prognosis in Han Chinese population |
| Received:December 11, 2019 Revised:January 04, 2020 |
| DOI：10.1007/s10330-019-0397-7 |
| 中文关键词: 白细胞介素18， 肾癌，基因多态性，预后 |
| 英文关键词: Interleukin-18; renal cell carcinoma; Polymorphism; Prognosis |
| 基金项目:中国博士后课题基金，江苏省南通市科技课题基金 |
| Author Name | Affiliation | E-mail | | Shaojun Nong* | Department of Urological Surgery,The Affiliated Hospital of Nantong University | shaojunnong@sina.com | | Yangbo Guan | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Zhongqing Wei# | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Yueping Zhang | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Bin Cheng | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Chongsheng He | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Limin Ma | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Shujun Zhou | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Wenguang Li | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Jian Ni | Department of Urological Surgery,The Affiliated Hospital of Nantong University | | | Zhiwei Wang | Department of Urological Surgery,The Affiliated Hospital of Nantong University | |
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| 中文摘要: |
| 目的：本研究目的探讨白细胞介素18两个启动子-137G/C和 -607C/A基因多态性和中国汉族肾癌复发和预后关系。
方法：通过检测175名汉族肾癌患者的两个启动子基因表达并进行跟踪随访，同时和200名健康对照组做对比。
结果：在进展性肾癌患者中发现携带-137G/ C 基因多态性的GG 基因型比GC基因型具有较高的表达[HR=2.15, 95%CI=1.270-3.687].但我们发现在肾癌复发患者中两个启动子等位基因型表达无统计学意义。
结论 有证据表明细胞介素18启动子-137G/C表达影响肾癌患者的预后 |
| 英文摘要: |
| Objective This study was to examine a possible association between two promoter polymorphisms, -137G/C and -607C/A, in the IL-18 gene and renal cell carcinoma occurrence and prognosis in Han Chinese.
Methods We used a high-resolution melting method to genotype these two polymorphisms in 175 Chinese Han patients with renal cell carcinoma enrolled to follow-up in this study and in 200 age-matched healthy controls.
Result Carriers of the GG genotype of the -137G/ C polymorphism had 2.165 time higher risk of renal cell carcinoma progression than carriers of GC[HR=2.15, 95%CI=1.270-3.687]. However, we found no significant association of genotype or allele distributions of these two polymorphisms with occurrence of renal cell carcinoma.
Conclusion We conclude that there is evidence that the IL-18 gene promoter polymorphism -137G/C influences the prognosis of renal cell carcinoma patients. |
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