| Xinhui QI,Shuxian Qu,Cheng Du,Jianing Qiu,Yongming Liu,Jingyu Li,Zhendong Zheng. Effects of enteral nutrition intervention on immune and nutritional indexes of patients with gastric malignant cancer during postoperative chemotherapy. Oncol Transl Med, 2020, 6: 222-227. |
| Effects of enteral nutrition intervention on immune and nutritional indexes of patients with gastric malignant cancer during postoperative chemotherapy |
| Received:November 29, 2019 Revised:October 12, 2020 |
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| KeyWord:Gastrointestinal malignancy; enteral nutrition; immune-enhanced nutrition support therapy |
| Author Name | Affiliation | E-mail | | Xinhui QI | Department of Oncology, General Hospital of Northern Theater Command, Shenyang 110016, China | qixinhui7@sina.com | | Shuxian Qu | Department of Oncology, General Hospital of Northern Theater Command, Shenyang 110016, China | | | Cheng Du | Department of Oncology, General Hospital of Northern Theater Command, Shenyang 110016, China | | | Jianing Qiu | Department of Oncology, General Hospital of Northern Theater Command, Shenyang 110016, China | | | Yongming Liu | Department of Oncology, General Hospital of Northern Theater Command, Shenyang 110016, China | | | Jingyu Li | Department of Oncology, General Hospital of Northern Theater Command, Shenyang 110016, China | | | Zhendong Zheng | Department of Oncology, General Hospital of Northern Theater Command, Shenyang 110016, China | zhengzhdong@163.com |
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| Abstract: |
| Objective: The aim of this study was to investigate changes in nutritional status and related indexes in
patients with Nutritional Risk Score (NRS) ≥ 3 gastric cancer after nutritional support treatment.
Methods: A total of 50 patients with gastric cancer were divided into two groups according to the different
nutritional support treatment they received during postoperative chemotherapy: immune-enhanced enteral
nutrition group (n = 25) and conventional enteral nutrition group (n = 25). Changes in patient’ body mass
index (BMI), hemoglobin (HB), serum total protein (TP), serum albumin (ALB), and immune indexes (CD3+,
CD4+/CD8+, CD3+/CD8+) were monitored before and after chemotherapy. At the same time, the incidence
and classification of gastrointestinal adverse reactions after chemotherapy were assessed.
Results: Compared with the conventional enteral nutrition group, the nutritional and immune indexes
in the immune-enhanced enteral nutrition group were significantly improved. After chemotherapy, the
incidence of adverse reactions in the digestive tract was relatively lower and the grade was reduced.
Conclusion: Immune-enhanced enteral nutrition support can significantly improve the nutritional status of
patients, improve immune function, increase the susceptibility of cancer patients to chemotherapy, reduce
toxicity and adverse effects, and improve the quality of life of tumor patients compared with conventional
enteral nutrition support. |
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