| Xinhui QI,Shuxian Qu,Cheng Du,Jianing Qiu,Yongming Liu,Jingyu Li,Zhendong Zheng. Effects of enteral nutrition intervention on immune and nutritional indexes of patients with gastric malignant cancer during postoperative chemotherapy. Oncol Transl Med, 2020, 6: 222-227. |
| 肠内营养对胃恶性肿瘤术后化疗期间免疫指标及营养指标的影响 |
| Effects of enteral nutrition intervention on immune and nutritional indexes of patients with gastric malignant cancer during postoperative chemotherapy |
| Received:November 29, 2019 Revised:October 12, 2020 |
| DOI：10.1007/s10330-019-0394-4 |
| 中文关键词: 消化道恶性肿瘤；肠内营养；免疫增强型营养支持治疗 |
| 英文关键词: Gastrointestinal malignancy; enteral nutrition; immune-enhanced nutrition support therapy |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Xinhui QI | Department of Oncology, General Hospital of Northern Theater Command, Shenyang 110016, China | qixinhui7@sina.com | | Shuxian Qu | Department of Oncology, General Hospital of Northern Theater Command, Shenyang 110016, China | | | Cheng Du | Department of Oncology, General Hospital of Northern Theater Command, Shenyang 110016, China | | | Jianing Qiu | Department of Oncology, General Hospital of Northern Theater Command, Shenyang 110016, China | | | Yongming Liu | Department of Oncology, General Hospital of Northern Theater Command, Shenyang 110016, China | | | Jingyu Li | Department of Oncology, General Hospital of Northern Theater Command, Shenyang 110016, China | | | Zhendong Zheng* | Department of Oncology, General Hospital of Northern Theater Command, Shenyang 110016, China | zhengzhdong@163.com |
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| 中文摘要: |
| 摘要：目的 探讨对NRS≥3的胃恶性肿瘤患者进行营养支持治疗后患者整体营养状况及相关指标的变化。方法 收集我院50例胃恶性肿瘤术后患者，随机分为免疫增强型肠内营养治疗（25例）及常规肠内营养治疗（25例），应用NRS评估结合实验室指标对恶性肿瘤患者进行营养不良的筛查。观察两组患者体重指数（BMI）,血红蛋白（HB）,血清总蛋白（TP），血清白蛋白（ALB），免疫指标：CD3+、CD4+/CD8+、CD3+/CD8+在化疗前后的变化情况以及化疗后消化道不良反应的发生率及分级情况。结果 50例胃恶性肿瘤患者,免疫增强型肠内营养组较常规肠内营养组，各项营养指标及免疫指标均有提高，具有显著性差异。且化疗后消化道不良反应发生率相对较低，分度更轻。结论 免疫增强型肠内营养治疗较常规肠内营养治疗，可明显改善患者的营养状态，改善机体免疫功能，提高肿瘤患者对化疗的耐受性，降低毒副作用，改善肿瘤患者的生活质量。 |
| 英文摘要: |
| Objective: The aim of this study was to investigate changes in nutritional status and related indexes in
patients with Nutritional Risk Score (NRS) ≥ 3 gastric cancer after nutritional support treatment.
Methods: A total of 50 patients with gastric cancer were divided into two groups according to the different
nutritional support treatment they received during postoperative chemotherapy: immune-enhanced enteral
nutrition group (n = 25) and conventional enteral nutrition group (n = 25). Changes in patient’ body mass
index (BMI), hemoglobin (HB), serum total protein (TP), serum albumin (ALB), and immune indexes (CD3+,
CD4+/CD8+, CD3+/CD8+) were monitored before and after chemotherapy. At the same time, the incidence
and classification of gastrointestinal adverse reactions after chemotherapy were assessed.
Results: Compared with the conventional enteral nutrition group, the nutritional and immune indexes
in the immune-enhanced enteral nutrition group were significantly improved. After chemotherapy, the
incidence of adverse reactions in the digestive tract was relatively lower and the grade was reduced.
Conclusion: Immune-enhanced enteral nutrition support can significantly improve the nutritional status of
patients, improve immune function, increase the susceptibility of cancer patients to chemotherapy, reduce
toxicity and adverse effects, and improve the quality of life of tumor patients compared with conventional
enteral nutrition support. |
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