| Guobo Du,Qian Zhou,Xinyao He,Long Cheng,Jing Zhou. Glioblastoma multiforme with metastasis to. Oncol Transl Med, 2020, 6: 36-38. |
| 胶质母细胞瘤肺、骨、胸壁转移1例 |
| Glioblastoma multiforme with metastasis to |
| Received:November 26, 2019 Revised:March 12, 2020 |
| DOI：10.1007/s10330-019-0393-3 |
| 中文关键词: 颅外胶质母细胞瘤；多形性胶质母细胞瘤；转移瘤 |
| 英文关键词: extracranial glioblastoma; glioblastoma multiforme; metastases |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Guobo Du | Affiliated Hospital of North Sichuan Medical College | duguobo@yeah.net | | Qian Zhou | North Sichuan Medical College | | | Xinyao He | North Sichuan Medical College | | | Long Cheng | Affiliated Hospital of North Sichuan Medical College | | | Jing Zhou* | Affiliated Hospital of North Sichuan Medical College | zj8126118@yeah.net |
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| 中文摘要: |
| 多形性胶质母细胞瘤(GBM)是一种常见的脑肿瘤，很少发生颅外转移。我们报告一位40岁男性，左颞叶胶质母细胞瘤患者接受开颅手术，术后放化疗，反应良好。诊断后11个月，患者出现肿瘤转移到胸壁、双肺和骨。给予患者2周期紫杉醇联合顺铂化疗后病情进展，诊断14个月后因转移椎体病理学骨折导致截瘫，最后诊断第19个月后死于全身衰竭。
结论: GBM颅外转移非常罕见。我们报道一例GBM患者术后出现肺、骨、胸壁转移，对化疗不敏感。需要更多的报道及进一步研究。 |
| 英文摘要: |
| Glioblastoma multiforme (GBM) is a common brain tumor that rarely metastasizes extra-cranially. We
present the case of a 40-year-old male with left temporal GBM who underwent craniotomy followed by
radiotherapy and chemotherapy. Postoperative MRI scans at different time intervals demonstrated a good
response. Eleven months after the initial diagnosis, there were no clinical or radiological signs suggesting
recurrence. However, the tumor showed metastasis simultaneously to the chest wall, lungs, and bone,
despite 2 cycles of chemotherapy. The patient developed paraplegia 14 months after the initial diagnosis
and died due to systemic failure 19 months after diagnosis. Extracranial metastasis of GBM is extremely
rare. We present the unusual case of a patient with GBM who showed simultaneous metastasis to the
lungs, bone, and chest wall. The prognosis of patients with extracranial metastasis of glioblastomas is very
poor, regardless of chemoradiotherapy. Newer approaches, such as immunotherapy and anti-angiogenic
therapy, need to be further studied. |
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