| Gang Zhou,Xiangyu Meng,Shangqin Liu. Association between diabetes mellitus, hypertension, hyperlipidemia, chronic viral hepatitis, and the risk of multiple myeloma: a case-control study. Oncol Transl Med, 2020, 6: 87-92. |
| 糖尿病、高血压、高脂血症、慢性病毒性肝炎与多发性骨髓瘤的发病风险分析 |
| Association between diabetes mellitus, hypertension, hyperlipidemia, chronic viral hepatitis, and the risk of multiple myeloma: a case-control study |
| Received:November 12, 2019 Revised:April 29, 2020 |
| DOI：10.1007/s10330-019-0391-1 |
| 中文关键词: 多发性骨髓瘤；糖尿病；高血压；高脂血症；病毒性肝炎；病例对照研究 |
| 英文关键词: multiple myeloma (MM); diabetes mellitus (DM); hypertension; hyperlipidemia; chronic viral hepatitis; case-control study |
| 基金项目:黄芩素诱导白血病细胞凋亡和克服耐药的分子机制探讨（国家自然科学基金面上项目，8147007） |
| Author Name | Affiliation | E-mail | | Gang Zhou | Department of Hematology, Zhongnan Hospital of Wuhan University | 1021848223@qq.com | | Xiangyu Meng | Department of Urology Surgery, Zhongnan Hospital of Wuhan University | | | Shangqin Liu* | Department of Hematology, Zhongnan Hospital of Wuhan University | ubeliu@aliyun.com |
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| 中文摘要: |
| 目的：通过病例对照研究，探究糖尿病（DM）、高血压病、高脂血症、慢性病毒性肝炎是否是多发性骨髓瘤（MM）发病的危险因素，并对是否合并上述暴露因素的MM患者的临床特征进行分析。方法：收集340例MM患者以及680例2012年1月至2017年12月入院的良性疾病住院患者分别作为病例组与对照组，通过病历资料回顾的方式明确其DM、高血压、高脂血症、慢性病毒性肝炎病史，通过单因素与多因素分析比较两组DM、高血压、高脂血症、慢性病毒性肝炎病史是否存在差异。以DM、高血压、高脂血症、慢性病毒性肝炎作为暴露因素，对暴露因素组和非暴露因素组的MM患者的肾功能、真菌感染、其他感染等临床特征进行分析比较，以探究其是否存在差异。结果： MM患者与对照组之间DM、高血压、高脂血症的发病率无明显差异。MM患者慢性病毒性肝炎者发病率高于同期良性疾病住院患者（P<0.01）。有无DM、高血压、高脂血症的MM患者住院期间的肾功能异常、真菌感染、其他感染的患病率均无显著差别。有慢性病毒性肝炎的MM患者住院治疗期间合并非真菌感染的几率显著高于无慢性病毒性肝炎的MM患者（OR = 4.2， P = 0.01）。结论：DM、高血压、高脂血症和MM的发病没有显著关联，慢性病毒性肝炎显著增加MM的风险，同时增加MM患者发生非真菌感染的几率。虽然没有显著的统计学意义，但可以看出DM和高血压有增加MM发病风险的趋势，后续需要大样本研究进行进一步探索和验证。 |
| 英文摘要: |
| Objective This case-control study aimed to investigate whether diabetes mellitus (DM), hypertension,
hyperlipidemia, and chronic viral hepatitis are risk factors for multiple myeloma (MM). Moreover, the clinical
characteristics of MM patients with or without the abovementioned exposure factors were analyzed.
Methods In total, 340 MM patients and 680 patients with benign diseases who were hospitalized from
January 2012 to December 2017 were classified under the case group and control group, respectively.
Data about medical history of DM, hypertension, hyperlipidemia and chronic viral hepatitis were collected
by reviewing medical records. Univariate and multivariate analyses were conducted to compare the
history of DM, hypertension, hyperlipidemia, and viral hepatitis between the two groups. Considering DM,
hypertension, hyperlipidemia, and chronic viral hepatitis as exposure factors, clinical characteristics, such
as renal function and presence of fungal and other types of infections, between the exposed and nonexposed
groups were analyzed.
Results No significant difference was observed in the prevalence of DM, hypertension, and
hyperlipidemia between the case and control groups. MM patients had a higher prevalence of chronic viral
hepatitis than those with benign diseases. No significant difference was observed in the prevalence of renal
dysfunction, fungal infection, and non-fungal infections in MM patients with or without DM, hypertension,
and hyperlipidemia. MM patients with chronic viral hepatitis had a significantly higher prevalence of nonfungal
infections during hospitalization than those without.
Conclusion No significant association was noted between MM and DM, hypertension, and hyperlipidemia.
Chronic viral hepatitis is correlated to a significantly higher risk of MM, and MM patients with chronic viral
hepatitis were more susceptible to non-fungal infections during hospitalization. Although a non-significant
trend was observed in this study, we believe that DM and hypertension might be associated with a higher
risk of MM. Thus, large-scale studies must be conducted to validate the results of the current study |
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