| Qian Zhang,Jie Tang,Xiaojie Ma,Jiayu Du. Radiation-induced brain injury after a conventional dose of intensity-modulated radiotherapy for nasopharyngeal carcinoma: a case report and literature review. Oncol Transl Med, 2020, 6: 30-35. |
| 常规剂量下调强放疗鼻咽癌后放射性脑损伤病例报告及文献复习 |
| Radiation-induced brain injury after a conventional dose of intensity-modulated radiotherapy for nasopharyngeal carcinoma: a case report and literature review |
| Received:October 11, 2019 Revised:March 18, 2020 |
| DOI：10.1007/s10330-019-0383-3 |
| 中文关键词: 放射性脑损伤，鼻咽癌，VMAT |
| 英文关键词: radiation-induced brain injury; nasopharyngeal carcinoma; VMAT |
| 基金项目:四川省医学科研青年创新课题（编号：Q18031）、2018年市校战略合作科研项目(编号：18SXHZ0542)资助 |
| Author Name | Affiliation | E-mail | | Qian Zhang | Department of Oncology, affiliated Hospital of North Sichuan Medical College | 1002060536@qq.com | | Jie Tang | Department of Oncology, affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China | | | Xiaojie Ma* | Department of Oncology, affiliated Hospital of North Sichuan Medical College | 992437730@qq.com | | Jiayu Du | Department of Oncology, affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China | |
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| 中文摘要: |
| 病例介绍 一例61岁女性鼻咽癌患者，经VMAT常规剂量放疗开始后后1月余，突发认知功能障碍入院，初步诊断为放射性脑损伤，经固醇类激素等综合治疗后，患者症状迅速好转。结论 对于鼻咽癌患者行VMAT，临床认为：颞叶小于65Gy或者１％的体积＜65Gy时出现放射性脑损伤的几率极低，超过此数值会出现不同程度的放射性脑损伤。本例患者颞叶受照剂量小于此值，但仍然出现了放射性脑损伤，其临床的特殊性可供参考，需引起临床医生的重视。 |
| 英文摘要: |
| A 61-year-old female nasopharyngeal carcinoma patient was admitted to the hospital with sudden
cognitive dysfunction one month after Volumetric Intensity Modulated Arc Therapy (VMAT) conventional
dose radiotherapy, and the initial diagnosis was radiation-induced brain injury (RBI). After comprehensive
treatment with steroid hormones, the patient’s condition rapidly improved. Typically, in nasopharyngeal
carcinoma patients treated with VMAT, the incidence of RBI is extremely low when the temporal lobe dose
is less than 65 Gy or 1% of the volume is less than 65 Gy. When this limit is exceeded, RBI may occur
in varying degrees. However, in this case, even though the temporal lobe dose was under the prescribed
limit, the patient still experienced RBI. The rare observations in this case can be used as a reference, and
clinicians should seriously consider the possibility of RBI in similar cases. |
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