| Lu Gan,Mo Li,Mo Li (Co-first author),Tongtao Yang (Co-first author),Tongtao Yang,Jin Wu,Junjie Du,Zhuojing Luo,Yong Zhou. Expression of HERG in musculoskeletal tumors with different degrees of malignancy. Oncol Transl Med, 2019, 5: 242-248. |
| HERG在不同恶性程度骨与软组织肿瘤中的表达 |
| Expression of HERG in musculoskeletal tumors with different degrees of malignancy |
| Received:August 26, 2019 Revised:November 20, 2019 |
| DOI：10.1007/s10330-019-0376-6 |
| 中文关键词: HERG；钾离子通道；骨肿瘤；表达 |
| 英文关键词: HERG; potassium ion channel; musculoskiletal tumors; expression |
| 基金项目:陕西省重点研究课题编号：2018YBXM-SF-12-2 |
| Author Name | Affiliation | Department | | Lu Gan | Department of orthopedics, Xijing hospital, air force medical university | Orthopeadics | | Mo Li | Department of orthopedics, Xijing hospital, air force medical university | Orthorpeadics | | Mo Li (Co-first author) | | | | Tongtao Yang (Co-first author) | | | | Tongtao Yang | Department of orthopedics, second affiliated hospital of air force medical university | Orthorpeadics | | Jin Wu | The 175th hospital of the PLA | Orthorpeadics | | Junjie Du | | | | Zhuojing Luo | Department of orthopedics, first affiliated hospital of air force medical university | Orthopedics | | Yong Zhou* | Department of orthopedics, second affiliated hospital of air force medical university | Orthorpeadics |
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| 中文摘要: |
| 摘要 背景 HERG表达在常见骨肿瘤中报道较少，缺乏足够的研究。目的 探讨HERG在多种常见的肌肉骨骼系统肿瘤中的表达。方法采用免疫组化染色等方法;RT-PCR和western blot检测不同组织和细胞株中HERG s的表达差异。结果 我们的研究表明，HERG在不同的恶性肿瘤中均有不同程度、不同部位的表达，但在正常骨组织中无表达。某些阻滞剂4-AP能明显抑制骨肉瘤细胞株的增殖。结论HERG在恶性肿瘤中呈高表达，其阻断剂能有效抑制恶性肿瘤的增殖 |
| 英文摘要: |
| Objective The expression of HERG in common bone tumors is scarcely reported and there is a lack
of dedicated studies. This study aimed to investigated the expression of HERG in several common
musculoskeletal tumors.
Methods Immunohistochemical staining, RT-PCR, and Western blotting were used to observe HERG
expression differences in various tissues and cell lines.
Results HERG was differentially expressed in different malignant tumors, both at a differential protein
level and localization within tumors. HERG was not expressed in normal bone tissue. The HERG inhibitor
E-4031 markedly inhibited the proliferation of osteosarcoma cell lines.
Conclusion HERG was highly expressed in malignant tumors. Blocking of HERG can effectively inhibit
the proliferation of bone tumors. |
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