| Lu Gan,Mo Li,Mo Li (Co-first author),Tongtao Yang (Co-first author),Tongtao Yang,Jin Wu,Junjie Du,Zhuojing Luo,Yong Zhou. Expression of HERG in musculoskeletal tumors with different degrees of malignancy. Oncol Transl Med, 2019, 5: 242-248. |
| Expression of HERG in musculoskeletal tumors with different degrees of malignancy |
| Received:August 26, 2019 Revised:November 20, 2019 |
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| KeyWord:HERG; potassium ion channel; musculoskiletal tumors; expression |
| Author Name | Affiliation | Department | | Lu Gan | Department of orthopedics, Xijing hospital, air force medical university | Orthopeadics | | Mo Li | Department of orthopedics, Xijing hospital, air force medical university | Orthorpeadics | | Mo Li (Co-first author) | | | | Tongtao Yang (Co-first author) | | | | Tongtao Yang | Department of orthopedics, second affiliated hospital of air force medical university | Orthorpeadics | | Jin Wu | The 175th hospital of the PLA | Orthorpeadics | | Junjie Du | | | | Zhuojing Luo | Department of orthopedics, first affiliated hospital of air force medical university | Orthopedics | | Yong Zhou | Department of orthopedics, second affiliated hospital of air force medical university | Orthorpeadics |
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| Abstract: |
| Objective The expression of HERG in common bone tumors is scarcely reported and there is a lack
of dedicated studies. This study aimed to investigated the expression of HERG in several common
musculoskeletal tumors.
Methods Immunohistochemical staining, RT-PCR, and Western blotting were used to observe HERG
expression differences in various tissues and cell lines.
Results HERG was differentially expressed in different malignant tumors, both at a differential protein
level and localization within tumors. HERG was not expressed in normal bone tissue. The HERG inhibitor
E-4031 markedly inhibited the proliferation of osteosarcoma cell lines.
Conclusion HERG was highly expressed in malignant tumors. Blocking of HERG can effectively inhibit
the proliferation of bone tumors. |
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