| zhengfeng shi,Shuchun Lin,Xiaorong Tang,Hongli Zheng,Fei Wang,Wudong Tao. The expression of miR-155 and miR-181 in gastric cancer and their effects on clinical parameters and prognostic value. Oncol Transl Med, 2019, 5: 264-267. |
| miR-155、miR-181在胃癌中的表达及对临床病理参数、预后价值的影响 |
| The expression of miR-155 and miR-181 in gastric cancer and their effects on clinical parameters and prognostic value |
| Received:August 12, 2019 Revised:September 26, 2019 |
| DOI：10.1007/s10330-019-0372-2 |
| 中文关键词: miR-155；miR-181；胃癌；肿瘤标志物 |
| 英文关键词: ?miR-155; miR-181; gastric cancer; tumor markers |
| 基金项目:江苏省卫生计生委 2015 年度面上项目（H201518） |
| Author Name | Affiliation | E-mail | | zhengfeng shi | Fifth People''''s Hospital of Zhangjiagang | jianjian1919@163.com | | Shuchun Lin | Fifth People''''s Hospital of Zhangjiagang | | | Xiaorong Tang | Fifth People''''s Hospital of Zhangjiagang | | | Hongli Zheng | Fifth People''''s Hospital of Zhangjiagang | | | Fei Wang | Fifth People''''s Hospital of Zhangjiagang | | | Wudong Tao* | Fifth People''''s Hospital of Zhangjiagang | Jianjian 1919@163.com |
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| 中文摘要: |
| 目的：探讨miR-155、miR-181在胃癌中的表达及对临床病例参数、
预后价值的影响。方法：选取68例胃癌患者及80例健康志愿者为研究对象。收集患者、志愿者的血清样本，及患者的手术标本，检测血清及肿瘤组织中miR-155、miR-181的表达水平。结果：（1）与正常组相比，胃癌组患者血清中的miR-155、miR-181水平显著较高（P＜0.05）。（2）miR-155、miR-181在胃癌组织中的表达水平分别为（16.74±4.29）、（12.17±3.26），在癌旁组织中的表达水平为（3.42±0.39）、（3.06±0.69），在正常组织中的表达水平为（1.22±0.21）、（1.08±0.35）。miR-155、miR-181癌组织中的表达水平显著较高，癌旁组织中次之，正常组织中最低（P＜0.05）。（4）miR-155、miR-181的高表达对患者分化程度、T分期、淋巴结转移、临床分期有明显影响（P＜0.05）。Cox多因素分析发性，T 分期，临床分期、分化程度、淋巴结转移、miR-155、miR-181是胃癌患者预后的独立危险因素。结论：血清miR-155、miR-181对胃癌有一定诊断价值．且是患者预后不良的强烈信号。 |
| 英文摘要: |
| ?Objective The aim of this study was to investigate the expression and clinical significance of miR-155
and miR-181 in gastric cancer.
Methods Sixty-eight patients with gastric cancer and 80 healthy volunteers were selected as subjects.
Serum samples of patients and volunteers were collected to detect miR-155 and miR-181 expression levels
in serum and tumor tissues.
Results miR-155 and miR-181 serum levels were significantly higher in patients with gastric cancer than
those in the control group (P < 0.05). miR-155 and miR-181 expression levels in gastric cancer tissues
were 16.74 ± 4.29 and 12.17 ± 3.26, respectively and 3.42 ± 0.39) and 3.06 ± 0.69 in paracancerous
tissues, respectively, and they were 1.22 ± 0.21 and 1.08 ± 0.35 in normal tissues, respectively. miR-155
and miR-181 expression levels in cancer tissues were significantly higher than adjacent tissues, and they
were lowest in normal tissues (P < 0.05). High miR-155 and miR-181 expression had significant effects
on differentiation, T stage, lymph node metastasis, and clinical stage (P < 0.05). Cox multivariate analysis
showed that onset, T stage, clinical stage, differentiation degree, lymph node metastasis, miR-155, and
miR-181 were independent risk factors for prognosis of patients with gastric cancer.
Conclusion Serum miR-155 and miR-181 have a diagnostic value in gastric cancer, and they are strong
signals of poor prognosis. |
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