| zhengfeng shi,Shuchun Lin,Xiaorong Tang,Hongli Zheng,Fei Wang,Wudong Tao. The expression of miR-155 and miR-181 in gastric cancer and their effects on clinical parameters and prognostic value. Oncol Transl Med, 2019, 5: 264-267. |
| The expression of miR-155 and miR-181 in gastric cancer and their effects on clinical parameters and prognostic value |
| Received:August 12, 2019 Revised:September 26, 2019 |
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| KeyWord:?miR-155; miR-181; gastric cancer; tumor markers |
| Author Name | Affiliation | E-mail | | zhengfeng shi | Fifth People''''s Hospital of Zhangjiagang | jianjian1919@163.com | | Shuchun Lin | Fifth People''''s Hospital of Zhangjiagang | | | Xiaorong Tang | Fifth People''''s Hospital of Zhangjiagang | | | Hongli Zheng | Fifth People''''s Hospital of Zhangjiagang | | | Fei Wang | Fifth People''''s Hospital of Zhangjiagang | | | Wudong Tao | Fifth People''''s Hospital of Zhangjiagang | Jianjian 1919@163.com |
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| Abstract: |
| ?Objective The aim of this study was to investigate the expression and clinical significance of miR-155
and miR-181 in gastric cancer.
Methods Sixty-eight patients with gastric cancer and 80 healthy volunteers were selected as subjects.
Serum samples of patients and volunteers were collected to detect miR-155 and miR-181 expression levels
in serum and tumor tissues.
Results miR-155 and miR-181 serum levels were significantly higher in patients with gastric cancer than
those in the control group (P < 0.05). miR-155 and miR-181 expression levels in gastric cancer tissues
were 16.74 ± 4.29 and 12.17 ± 3.26, respectively and 3.42 ± 0.39) and 3.06 ± 0.69 in paracancerous
tissues, respectively, and they were 1.22 ± 0.21 and 1.08 ± 0.35 in normal tissues, respectively. miR-155
and miR-181 expression levels in cancer tissues were significantly higher than adjacent tissues, and they
were lowest in normal tissues (P < 0.05). High miR-155 and miR-181 expression had significant effects
on differentiation, T stage, lymph node metastasis, and clinical stage (P < 0.05). Cox multivariate analysis
showed that onset, T stage, clinical stage, differentiation degree, lymph node metastasis, miR-155, and
miR-181 were independent risk factors for prognosis of patients with gastric cancer.
Conclusion Serum miR-155 and miR-181 have a diagnostic value in gastric cancer, and they are strong
signals of poor prognosis. |
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