| Xu HanYou. Stereotactic radiotherapy for the treatment of nasopharyngeal carcinoma: a Meta-analysis of 1371 cases in China. Oncol Transl Med, 2019, 5: 293-300. |
| Stereotactic radiotherapy for the treatment of nasopharyngeal carcinoma: a Meta-analysis of 1371 cases in China |
| Received:July 19, 2019 Revised:December 26, 2019 |
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| KeyWord:Stereotatic radiotherapy; Residual nasopharyngeal carcinoma; Recurrent nasopharyngeal carcinoma; Meta-analysis; Total radiation dose; Radiotherapy. |
| Author Name | Affiliation | E-mail | | Xu HanYou | Department of High Dependency Unit, Tongxiong Oriental Hospital | abc13579-you@126.com |
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| Abstract: |
| Objective The aim of this study was to clarify the results of treatment of local residual and (or) local
recurrent nasopharyngeal carcinoma and to promote scientific clinical treatment and research regarding
stereotactic radiotherapy in China and other countries.
Methods This Meta-analysis conducted a literature search using the China National Knowledge
Infrastructure database for all clinical research articles on stereotactic radiotherapy for the treatment of local
residual and(or) local recurrent nasopharyngeal carcinoma in China. Data on patient cohort numbers and
other research factors were recorded for every relevant clinical research article. Calculated and analyzed
these fact sheets to pave the way for the objective of this project.
Results A total of 40 clinical research articles including 1,371 patients in China from 1998 to 2012 were
identified. The average cohort size was 34 patients (range 9–98 patients). The average total radiation dose
range was 16–33.6 Gy. The average study or treatment duration was 3.51 years. The calculated average
follow-up time was 31.59 months.
Conclusion The study provided the largest resource for further research and Meta-analyses to determine
the clinical pathway of stereotactic radiotherapy for the treatment of local residual and (or) local recurrent
nasopharyngeal carcinoma. The results indicated that variability in the total radiation dose, treatment
or research time, and follow-up duration may have contributed to the complications and side effects of
stereotactic radiotherapy for local residual and (or) local recurrent nasopharyngeal carcinoma in China.
The calculated average total radiation dose, follow-up time, and treatment and research durations may be
referenced for future treatment and research. This study also proposed worldwide cooperation for the metaanalysis of research articles on stereotactic radiotherapy for treating local residual and (or) local recurrent
nasopharyngeal carcinoma. |
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