| Xu HanYou. Stereotactic radiotherapy for the treatment of nasopharyngeal carcinoma: a Meta-analysis of 1371 cases in China. Oncol Transl Med, 2019, 5: 293-300. |
| 中国1371例行立体定向放射治疗鼻咽癌病人的荟萃分析 |
| Stereotactic radiotherapy for the treatment of nasopharyngeal carcinoma: a Meta-analysis of 1371 cases in China |
| Received:July 19, 2019 Revised:December 26, 2019 |
| DOI：10.1007/s10330-019-0368-8 |
| 中文关键词: 立体定向放射治疗；残留鼻咽癌；复发性鼻咽癌；荟萃分析；总放射剂量；放射治疗学。 |
| 英文关键词: Stereotatic radiotherapy; Residual nasopharyngeal carcinoma; Recurrent nasopharyngeal carcinoma; Meta-analysis; Total radiation dose; Radiotherapy. |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Xu HanYou* | Department of High Dependency Unit, Tongxiong Oriental Hospital | abc13579-you@126.com |
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| 中文摘要: |
| 目的：本研究的目的是为了提高立体定向放射治疗鼻咽癌的治疗效果，促进国内外更进一步科学研究立体定向放射治疗鼻咽癌的科学方法。
方法：在中国知网上搜索中国立体定向放射治疗鼻咽癌的相关研究论文，记录相关研究论文的病例数、放射总剂量、随访时间等，研究内容，以利于研究分析。
结果：总共搜索到40篇、1371例病人参与关于中国立体定向放射治疗局部残留和（或）局部复发性鼻咽癌的相关研究论文，研究论文发表的年限为1998-2012年，平均每项研究纳入病人的参与数为34，其中最大的研究纳入最多的病人数为98人，最小的研究纳入最少的病人数为9人，平均的放射总量为16—33.6Gy，病人平均的治疗时间为3.51年，平均的随访时间为31.59月。
结论：这项研究为进一步荟萃分析研究获得立体定向放射治疗局部残留和（或）局部复发性鼻咽癌病人的临床路径，提供了最大的病例和病例研究资源，本研究提出，中国国内立体定向放射治疗局部残留和（或）局部复发性鼻咽癌病人的放射总剂量、治疗或研究时间和随访时间不统一，可能是立体定向放射治疗局部残留和（或）局部复发性鼻咽癌病人所产生复杂或严重副作用的原因。
本研究所得到的，立体定向放射治疗平均放射总量、平均治疗时间和平均的随访时间，可以作为研究和治疗局部残留和（或）局部复发性鼻咽癌病人的临床参考数据。
本研究倡议，进行纳入更多立体定向放射治疗局部残留和（或）局部复发性鼻咽癌病人相关研究项目论文和病人的国际合作性荟萃分析研究。 |
| 英文摘要: |
| Objective The aim of this study was to clarify the results of treatment of local residual and (or) local
recurrent nasopharyngeal carcinoma and to promote scientific clinical treatment and research regarding
stereotactic radiotherapy in China and other countries.
Methods This Meta-analysis conducted a literature search using the China National Knowledge
Infrastructure database for all clinical research articles on stereotactic radiotherapy for the treatment of local
residual and(or) local recurrent nasopharyngeal carcinoma in China. Data on patient cohort numbers and
other research factors were recorded for every relevant clinical research article. Calculated and analyzed
these fact sheets to pave the way for the objective of this project.
Results A total of 40 clinical research articles including 1,371 patients in China from 1998 to 2012 were
identified. The average cohort size was 34 patients (range 9–98 patients). The average total radiation dose
range was 16–33.6 Gy. The average study or treatment duration was 3.51 years. The calculated average
follow-up time was 31.59 months.
Conclusion The study provided the largest resource for further research and Meta-analyses to determine
the clinical pathway of stereotactic radiotherapy for the treatment of local residual and (or) local recurrent
nasopharyngeal carcinoma. The results indicated that variability in the total radiation dose, treatment
or research time, and follow-up duration may have contributed to the complications and side effects of
stereotactic radiotherapy for local residual and (or) local recurrent nasopharyngeal carcinoma in China.
The calculated average total radiation dose, follow-up time, and treatment and research durations may be
referenced for future treatment and research. This study also proposed worldwide cooperation for the metaanalysis of research articles on stereotactic radiotherapy for treating local residual and (or) local recurrent
nasopharyngeal carcinoma. |
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