| Qing Zhang,Juan Guo. Expression and clinical significance of CD90 and CD177 tumor stem cell markers in cervical cancer. Oncol Transl Med, 2019, 5: 170-174. |
| 肿瘤干细胞标志物CD90、CD177在宫颈癌组织中的表达及其临床意义 |
| Expression and clinical significance of CD90 and CD177 tumor stem cell markers in cervical cancer |
| Received:May 20, 2019 Revised:September 17, 2019 |
| DOI：10.1007/s10330-019-0360-0 |
| 中文关键词: CD90；CD177；宫颈癌 |
| 英文关键词: ?CD90; CD177; cervical cancer |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Qing Zhang* | Clinical Medical College of Jiangsu Medical Vocational College | dengchao0430@163.com | | Juan Guo | Department of Obstetrics and Gynecology, Yancheng Third People''s Hospital | |
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| 中文摘要: |
| 目的：探讨肿瘤干细胞标志物CD90、CD177在宫颈癌组织中的表达及临床意义。方法：选取102例宫颈癌、52例宫颈上皮内瘤变（CIN）、50例子宫良性病患者为研究对象。采用免疫组化法检测宫颈组织中CD90、CD177阳性率，对患者进行随访，统计分析CD90、CD177表达对宫颈癌患者临床病理参数及预后的影响。结果：（1）CD90在正常宫颈组织、上皮内瘤变组织、宫颈癌组织中的阳性率分别为3.7%、36.5%、79.4%，CD177的阳性率分别为1.8%、32.7%、74.5%。两两比较后发现，CD90、CD177在宫颈癌组织中的阳性率最高，CIN组织中次之，在正常组织中的阳性率最低，差异均具有统计学意义（P＜0.05）。（2）多因素Logistic分析结果发现，病理学分级、淋巴结转移、肿瘤直径是影响CD90、CD177表达的独立性危险因素（P＜0.05）。（3）spearman等级相关检验结果显示，CD90与CD177的表达呈中等强度的正相关关系（r=0.679，P=0.003）。（4）随访截止时间2019年1月。102例宫颈癌患者，死亡36例，生存66例，生存率64.7%。CD90阳性组患者死亡33例，阴性组死亡3例，总体生存率分别为59.3%、85.7%，差异具有统计学意义（χ2=4.606，P=0.031）。CD177阳性组患者死亡33例，阴性组死亡3例，总体生存率分别为56.6%、88.5%，差异具有统计学意义（χ2=5.166，P=0.023）。结论：CD90、CD177的表达对宫颈癌的临床病理参数均有一定的不良影响，且二者阳性表达是患者预后不良的危险因素。 |
| 英文摘要: |
| Objective To investigate the expression and clinical significance of CD90 and CD177 in cervical cancer.
Methods Cases of cervical cancer (n = 102), cervical intraepithelial neoplasia (CIN, n = 52), and benign
uterine disease (n = 50) were selected. The positive rates of CD90 and CD177 in the cervical tissues were
detected, and the significance of CD90 and CD177 expression was analyzed.
Results The positive rate of CD90 in normal cervical tissue, CIN, and cervical cancer was 3.7%, 36.5%,
and 79.4% respectively. The respective positive rates of CD177 were 1.8%, 32.7%, and 74.5%. The
positive rates of CD90 and CD177 in cervical cancer tissues were the highest, followed by CIN tissues (P
< 0.05). Multivariate analysis showed that pathological grade, lymph node metastasis, and tumor diameter
were independent risk factors affecting the expression of CD90 and CD177 (each P < 0.05). There was
a moderate positive correlation between CD90 and CD177 expression (r = 0.679, P = 0.003). The overall
survival rate of 102 patients with cervical cancer was 64.7%. There were 33 deaths in the CD90 positive
group and 3 in the negative group. The overall survival rates were 59.3% and 85.7% in the CD90 and
negative group, respectively. There were 33 deaths in the CD177 positive group and 3 in the negative
group. The overall survival rates were 56.6% and 88.5%, respectively. The difference was statistically
significant.
Conclusion The expression of CD90 and CD177 has some adverse effects on the clinicopathological
parameters of cervical cancer. The positive expression of CD90 and CD177 is a risk factor for poor
prognosis. |
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