| Qing Zhang,Juan Guo. Expression and clinical significance of CD90 and CD177 tumor stem cell markers in cervical cancer. Oncol Transl Med, 2019, 5: 170-174. |
| Expression and clinical significance of CD90 and CD177 tumor stem cell markers in cervical cancer |
| Received:May 20, 2019 Revised:September 17, 2019 |
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| KeyWord:?CD90; CD177; cervical cancer |
| Author Name | Affiliation | E-mail | | Qing Zhang | Clinical Medical College of Jiangsu Medical Vocational College | dengchao0430@163.com | | Juan Guo | Department of Obstetrics and Gynecology, Yancheng Third People''s Hospital | |
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| Abstract: |
| Objective To investigate the expression and clinical significance of CD90 and CD177 in cervical cancer.
Methods Cases of cervical cancer (n = 102), cervical intraepithelial neoplasia (CIN, n = 52), and benign
uterine disease (n = 50) were selected. The positive rates of CD90 and CD177 in the cervical tissues were
detected, and the significance of CD90 and CD177 expression was analyzed.
Results The positive rate of CD90 in normal cervical tissue, CIN, and cervical cancer was 3.7%, 36.5%,
and 79.4% respectively. The respective positive rates of CD177 were 1.8%, 32.7%, and 74.5%. The
positive rates of CD90 and CD177 in cervical cancer tissues were the highest, followed by CIN tissues (P
< 0.05). Multivariate analysis showed that pathological grade, lymph node metastasis, and tumor diameter
were independent risk factors affecting the expression of CD90 and CD177 (each P < 0.05). There was
a moderate positive correlation between CD90 and CD177 expression (r = 0.679, P = 0.003). The overall
survival rate of 102 patients with cervical cancer was 64.7%. There were 33 deaths in the CD90 positive
group and 3 in the negative group. The overall survival rates were 59.3% and 85.7% in the CD90 and
negative group, respectively. There were 33 deaths in the CD177 positive group and 3 in the negative
group. The overall survival rates were 56.6% and 88.5%, respectively. The difference was statistically
significant.
Conclusion The expression of CD90 and CD177 has some adverse effects on the clinicopathological
parameters of cervical cancer. The positive expression of CD90 and CD177 is a risk factor for poor
prognosis. |
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