| Jiaheng Li,Lina Zhang,Yue Wang,Meng Gu,Ziyu Wang,Weiying Li. Association of genetic polymorphisms of GSTM1 and smoking status with lung cancer risk. Oncol Transl Med, 2019, 5: 249-256. |
| GSTM1基因多态性和吸烟情况与肺癌发生风险存在相关性 |
| Association of genetic polymorphisms of GSTM1 and smoking status with lung cancer risk |
| Received:May 06, 2019 Revised:December 27, 2019 |
| DOI：10.1007/s10330-019-0354-4 |
| 中文关键词: GSTM1；遗传易感性；吸烟；肺癌 |
| 英文关键词: GSTM1; genetic susceptibility; smoking; lung cancer |
| 基金项目:国家自然科学基金 |
| Author Name | Affiliation | E-mail | | Jiaheng Li | Cell Biology Laboratory, Capital Medical University, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute | ljhhbmu@126.com | | Lina Zhang | Cell Biology Laboratory, Capital Medical University, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute | | | Yue Wang | Cell Biology Laboratory, Capital Medical University, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute | | | Meng Gu | Cell Biology Laboratory, Capital Medical University, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute | | | Ziyu Wang | Cell Biology Laboratory, Capital Medical University, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute | | | Weiying Li* | Cell Biology Laboratory, Capital Medical University, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute | li_weiying412@aliyun.com |
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| 中文摘要: |
| 目标：长时间吸烟会导致呼吸道上皮细胞受损。GSTM1基因多态性、吸烟状况与肺癌易感性之间的的相关研究并不完全一致。在本次研究中，我们鉴定了GSTM1的遗传多态性，并研究了GSTM1多态性、吸烟史和肺癌易感性之间的关联。
研究设计：病例对照研究
方法：采用聚合酶链反应（PCR）对217例肺癌患者和198例对照者的GSTM1基因多态性进行基因分型。收集人口统计学数据以及受试者的吸烟史。
结果：在病例组和对照组之间观察到GSTM1多态性存在显著差异（P = 0.024）。吸烟时间和吸烟指数在病例组和对照组之间有显著差异。随着吸烟时间和吸烟指数的增加，差异越来越明显。 GSTM1与吸烟之间存在协同作用（S = 3.35）。携带GSTM1基因缺乏型的吸烟者患肺癌发生风险增加了4.82倍。与野生型GSTM1相比，随着吸烟时间和吸烟指数的增加， GSTM1基因缺乏型患者患肺癌的风险越来越大。在不同的病理类型中未观察到GSTM1多态性存在显著差异。随着吸烟时间和吸烟指数的增加，患者的比例在不同的病理类型中增加。这种趋势在鳞状细胞癌中更为明显。与野生型GSTM1相比，随着吸烟时间和吸烟指数的增加，GSTM1基因缺乏型患者的比例增加（P = 0.003,0.017）。这种趋势主要发生在鳞状细胞癌。
结论：缺陷GSTM1与肺癌易感性有关。 特别是那些携带GSTM1基因缺乏型的吸烟者更容易患上肺癌。 与野生型GSTM1相比，GSTM1基因缺乏型吸烟时间超过30年并且吸烟指数超过400更容易引起肺癌。在GSTM1基因缺乏型中，随着吸烟时间和吸烟剂量的延长，鳞状细胞癌的风险增加 |
| 英文摘要: |
| Objective: Long-term cigarette smoke exposure damages the airway epithelium. However, the correlation
among GSTM1 gene polymorphism, smoking status, and lung cancer susceptibility remains unclear. This
study aimed to identify the genetic polymorphism of GSTM1 and examine the association of GSTM1
polymorphism and smoking history with lung cancer susceptibility.
Methods: The genetic polymorphism of GSTM1 was genotyped by polymerase chain reaction (PCR) in
217 lung cancer patients and 198 controls. The demographic data and smoking history of the patients were
collected. The age, sex, and residence of the two groups were also obtained.
Results: Significant differences in GSTM1 polymorphism were observed between the case and control
groups (P = 0.024). Smoking time and smoking index were significantly different between the case and
control groups. With the increase in smoking time and smoking index, the differences became more obvious.
There was a synergistic effect between GSTM1 and smoking (S = 3.35). The risk of developing lung cancer
increased 4.82 fold in smokers carrying deficient-type GSTM1. Compared with patients carrying wild-type
GSTM1, the risk of developing lung cancer was higher in those carrying deficient-type GSTM1 with the
increase in smoking time and smoking index. In different pathological types, no significant differences were
observed in GSTM1 polymorphism. In different pathological types, the proportions of patients increased
with the increase in smoking time and smoking index, especially the proportion of patients with squamous
cell carcinoma. Compared with wild-type GSTM1, the proportion of patients with deficient-type GSTM1
increased with the increase in smoking time and smoking index (P = 0.003 and 0.017). This trend was
mainly observed in those with squamous cell carcinoma.
Conclusion: GSTM1 mutation is associated with lung cancer susceptibility. Smokers carrying deficienttype
GSTM1 are more likely to develop lung cancer. Compared with patients carrying wild-type GSTM1,
smokers with deficient-type GSTM1 are more likely develop lung cancer when smoking time is more
than 30 years and smoking index is more than 400. In patients carrying deficient-type GSTM1, the risk of
developing squamous cell carcinoma increases with an increase in smoking time and smoking dose. |
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