| Xiaoying Quan. The combined prognostic value of pretreatment neutrophil-to-lymphocyte ratio, lymphocyte-tomonocyte ratio, and platelet-to-lymphocyte ratio in stage IE/IIE extranodal natural killer/T-cell lymphoma. Oncol Transl Med, 2019, 5: 137-146. |
| The combined prognostic value of pretreatment neutrophil-to-lymphocyte ratio, lymphocyte-tomonocyte ratio, and platelet-to-lymphocyte ratio in stage IE/IIE extranodal natural killer/T-cell lymphoma |
| Received:May 06, 2019 Revised:July 23, 2019 |
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| KeyWord:extranodal natural killer/T-cell; neutrophil-to-lymphocyte ratio; lymphocyte-to-monocyte ratio; platelet-to-lymphocyte ratio; prognosis |
| Author Name | Affiliation | E-mail | | Xiaoying Quan | Department of Medical Oncology, The Sixth People''''s Hospital of Chengdu | 1193084163@qq.com |
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| Abstract: |
| Objective This study aimed to explore the combined prognostic value of pretreatment neutrophil-tolymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in
newly diagnosed IE/IIE extranodal natural killer/T-cell lymphoma (ENKTL) treated with a P-Gemox regimen
combined with radiotherapy or radiotherapy alone.
Methods A total of 132 patients from 2009 to 2017 at the Sichuan Cancer Hospital were enrolled in
the study. The cutoff values of NLR, LMR, and PLR using overall survival (OS) rate as an endpoint were
obtained by the receiver operating curve.
Results The cutoff value of NLR was 3.5. Patients with high NLR had significantly shorter progressionfree survival (PFS) (P < 0.001) and OS (P < 0.001) than those with low NLR. Similarly, the cutoff value of
LMR was 3.0. The high LMR group had significantly longer PFS (P=0.001) and OS (P < 0.001) than the low
LMR group. Similarly, the cutoff value of PLR was 191.7. The high PLR group was significantly associated
with poor PFS (P < 0.001) and OS (P < 0.001) than the low PLR group. Furthermore, combining NLR, LMR,
and PLR to build a new model to stratify patients into low-, intermediate-, intermediate-high-, and high-risk
groups, there were also significant differences in PFS (P < 0.001) and OS (P < 0.001). The univariate
analysis showed that presenting B symptoms, stage IIE, local tumor invasion, Eastern Cooperative
Oncology Group score ≥ 2, elevated lactate dehydrogenase level, elevated NLR, decreased LMR, and
elevated PLR were significantly associated with poor survival. The multivariate analysis demonstrated that
PLR was an independent prognostic factor for both PFS (hazard ratio [HR] = 2.073, 95% confidence interval
[CI] = 1.080–3.981, P = 0.028) and OS (HR = 2.127, 95% CI = 1.102–4.107, P = 0.025).
Conclusion Elevated pretreatment PLR was a novel simple predictor of poor survival in patients with
stage IE/IIE ENKTL. Combining NLR, LMR, and PLR could provide additional stratification. |
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