| Luo Zhigang. Regulatory mechanisms of long non-coding RNAs. Oncol Transl Med, 2019, 5: 147-151. |
| Regulatory mechanisms of long non-coding RNAs |
| Received:March 28, 2019 Revised:March 28, 2019 |
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| KeyWord:long non-coding RNAs (lncRNAs); regulatory mechanisms; transcriptional factors; chromatin state, alternative splicing; RNA editing, microRNA (miRNA) |
| Author Name | Affiliation | Address | | Luo Zhigang | People’s Hospital of Jianyang city,Jianyang city Sichuan 644000 | 四川省简阳市医院路180号 |
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| Abstract: |
| Long non-coding RNAs (lncRNAs) belong to a large and complex family of RNAs, which play many
important roles in regulating gene expression. However, the mechanism underlying the dynamic expression
of lncRNAs is still not very clear. In order to identify lncRNAs and clarify the mechanisms involved, we
collected basic information and highlighted the mechanisms underlying lncRNA expression and regulation.
Overall, lncRNAs are regulated by several similar transcription factors and protein-coding genes. Epigenetic
modification (DNA methylation and histone modification) can also downregulate lncRNA levels in tissues
and cells. Moreover, lncRNAs may be degraded or cleaved via interaction with miRNAs and miRNAassociated protein complexes. Furthermore, alternative RNA splicing (AS) may play a significant role in the
post-transcriptional regulation of lncRNAs. |
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