| Xiaoying Quan,Chunzhi Wu,Lei Lei,Xiaoyan Chen,Bin Ye. The prognostic potential of pretreatment ?C-reactive protein to albumin ratio in stage ?IE/IIE extranodal natural killer/T-cell lymphoma. Oncol Transl Med, 2019, 5: 162-169. |
| C反应蛋白与白蛋白比值在IE/IIE期结外NK/T细胞淋巴瘤中预后意义 |
| The prognostic potential of pretreatment ?C-reactive protein to albumin ratio in stage ?IE/IIE extranodal natural killer/T-cell lymphoma |
| Received:March 26, 2019 Revised:September 09, 2019 |
| DOI：10.1007/s10330-019-0345-5 |
| 中文关键词: C反应蛋白与白蛋白比值；结外NK/T细胞淋巴瘤；预后 |
| 英文关键词: ?Key words: C-reactive protein to albumin ratio (CRP/Alb); extranodal NK/T cell lymphoma; prognosis ?introduction |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Xiaoying Quan | Department of Medical Oncology, The Sixth People''s Hospital of Chengdu | 1193084163@qq.com | | Chunzhi Wu | The Sixth People''s Hospital of Chengdu | | | Lei Lei | Department of Medical Oncology, The Sixth People''s Hospital of Chengdu | | | Xiaoyan Chen | Department of Medical Oncology, The Sixth People''s Hospital of Chengdu | | | Bin Ye* | Department of Medical Oncology, The Sixth People''s Hospital of Chengdu | 354539616@qq.com |
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| 中文摘要: |
| 目的：探讨C反应蛋白与白蛋白比值(CRP/Alb)在IE/IIE结外NK/T细胞淋巴瘤中预后意义。方法：回顾性分析2011年9月至2016年11月四川肿瘤医院初治的114例结外NK/T细胞淋巴瘤。以总生存率为终点，通过ROC曲线获取CRP/Alb的截断值。结果：CRP/Alb的最佳截断值为0.15。低CRP/Alb组3年PFS为78.6%，3年OS为80.7%。高CRP/Alb组3年PFS和OS分别为41.4%，45.2%，两组间的PFS ((P0.001))和OS ((P0.001))差异均有统计学意义。单因素分析显示，ECOG、IPI、CRP、GPS、CRP/Alb与PFS存在相关(P0.05)。同样，ECOG、LDH、IPI、CRP、GPS、CRP/Alb与OS也存在相关性(P0.05)。多因素分析进一步证实ECOG (P=0.033)和CRP/Alb (P=0.018)是影响PFS的独立预后因素。同时，ECOG (P=0.027)和CRP/Alb (P=0.025)是影响OS的独立预后因素。CRP/Alb能进一步区别GPS评分、IPI评分、KPI评分的低危组患者，差异有统计学意义(P0.05)。结论:CRP/Alb可作为早期结外NK/T细胞淋巴瘤一种新型预后标志物。 |
| 英文摘要: |
| ?Objective The aim of this study was to determine the prognostic significance of the C-reactive protein-to-
albumin ratio (CRP/Alb) for stage IE/IIE upper aerodigestive tract extranodal NK/T cell lymphoma patients.
Objective The aim of this study was to determine the prognostic significance of the C-reactive protein-toalbumin
ratio (CRP/Alb) for stage IE/IIE upper aerodigestive tract extranodal NK/T cell lymphoma patients.
Methods One hundred and fourteen patients diagnosed with extranodal NK/T cell lymphoma at Sichuan
Cancer Hospital from September 2011 to November 2016 were retrospectively reviewed. An optimal cutoff
value of CRP/Alb for overall survival rate as an endpoint was obtained using the receiver operating curve
(ROC).
Results The optimal cutoff value of CRP/Alb was 0.15. For the low CRP/Alb group, the 3-year
progression-free survival (PFS) was 78.6% and the 3-year overall survival (OS) was 80.7%. The 3-year
PFS and OS values for the high CRP/Alb group were 41.6% and 45.2%, respectively. Differences for PFS
(P < 0.001) and OS (P < 0.001) between the two groups were statistically significant. Univariate analysis
showed that ECOG, IPI, CRP, GPS, and CRP/Alb were significantly associated with PFS. Similarly, all five
were also significantly associated with OS. Multivariate analysis further confirmed that ECOG and CRP/
Alb were independent prognostic factors for both PFS and OS. Moreover, the cutoff value of CRP/Alb
showed superior prognostic ability in discriminating between patients with different outcomes in low-risk
group based on GPS, IPI, and KPI scores.
Conclusion CRP/Alb is a promising prognostic marker for early-stage extranodal NK/T cell lymphoma. |
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