| Xiaoying Quan,Chunzhi Wu,Lei Lei,Xiaoyan Chen,Bin Ye. The prognostic potential of pretreatment ?C-reactive protein to albumin ratio in stage ?IE/IIE extranodal natural killer/T-cell lymphoma. Oncol Transl Med, 2019, 5: 162-169. |
| The prognostic potential of pretreatment ?C-reactive protein to albumin ratio in stage ?IE/IIE extranodal natural killer/T-cell lymphoma |
| Received:March 26, 2019 Revised:September 09, 2019 |
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| KeyWord:?Key words: C-reactive protein to albumin ratio (CRP/Alb); extranodal NK/T cell lymphoma; prognosis ?introduction |
| Author Name | Affiliation | E-mail | | Xiaoying Quan | Department of Medical Oncology, The Sixth People''s Hospital of Chengdu | 1193084163@qq.com | | Chunzhi Wu | The Sixth People''s Hospital of Chengdu | | | Lei Lei | Department of Medical Oncology, The Sixth People''s Hospital of Chengdu | | | Xiaoyan Chen | Department of Medical Oncology, The Sixth People''s Hospital of Chengdu | | | Bin Ye* | Department of Medical Oncology, The Sixth People''s Hospital of Chengdu | 354539616@qq.com |
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| Abstract: |
| ?Objective The aim of this study was to determine the prognostic significance of the C-reactive protein-to-
albumin ratio (CRP/Alb) for stage IE/IIE upper aerodigestive tract extranodal NK/T cell lymphoma patients.
Objective The aim of this study was to determine the prognostic significance of the C-reactive protein-toalbumin
ratio (CRP/Alb) for stage IE/IIE upper aerodigestive tract extranodal NK/T cell lymphoma patients.
Methods One hundred and fourteen patients diagnosed with extranodal NK/T cell lymphoma at Sichuan
Cancer Hospital from September 2011 to November 2016 were retrospectively reviewed. An optimal cutoff
value of CRP/Alb for overall survival rate as an endpoint was obtained using the receiver operating curve
(ROC).
Results The optimal cutoff value of CRP/Alb was 0.15. For the low CRP/Alb group, the 3-year
progression-free survival (PFS) was 78.6% and the 3-year overall survival (OS) was 80.7%. The 3-year
PFS and OS values for the high CRP/Alb group were 41.6% and 45.2%, respectively. Differences for PFS
(P < 0.001) and OS (P < 0.001) between the two groups were statistically significant. Univariate analysis
showed that ECOG, IPI, CRP, GPS, and CRP/Alb were significantly associated with PFS. Similarly, all five
were also significantly associated with OS. Multivariate analysis further confirmed that ECOG and CRP/
Alb were independent prognostic factors for both PFS and OS. Moreover, the cutoff value of CRP/Alb
showed superior prognostic ability in discriminating between patients with different outcomes in low-risk
group based on GPS, IPI, and KPI scores.
Conclusion CRP/Alb is a promising prognostic marker for early-stage extranodal NK/T cell lymphoma. |
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