| Shaojun Nong,Yangbo Guan,Zhiwei Wang,Zhongqing Wei,Yueping Zhang,Jian Ni,Chongsheng He,Limin Ma,Shujun Zhou,Wenguang Li. Significant association between IL-18 and OCT4 gene polymorphisms in susceptibility and clinical characteristics of prostate cancer. Oncol Transl Med, 2019, 5: 123-130. |
| 白细胞介素-18和Oct4基因多态性和易感性在前列腺癌临床特征关联性研究 |
| Significant association between IL-18 and OCT4 gene polymorphisms in susceptibility and clinical characteristics of prostate cancer |
| Received:March 17, 2019 Revised:July 28, 2019 |
| DOI：10.1007/s10330-019-0342-2 |
| 中文关键词: 白细胞介素-18；Oct4；基因多态性；前列腺癌，临床特征 |
| 英文关键词: clinical characteristics; interleukin-18 (IL-18); octamer-binding transcription factor 4 (OCT4); polymorphism; prostate cancer |
| 基金项目:中国博士后科学基金 |
| Author Name | Affiliation | E-mail | | Shaojun Nong* | The Affiliated Hospital of Nantong University | shaojunnong@sina.com | | Yangbo Guan | The Affiliated Hospital of Nantong University | | | Zhiwei Wang | The Affiliated Hospital of Nantong University | | | Zhongqing Wei | The Second Affiliated Hospital of Nanjing Medical University, | | | Yueping Zhang | The Affiliated Hospital of Nantong University | | | Jian Ni | The Affiliated Hospital of Nantong University | | | Chongsheng He | The Affiliated Hospital of Nantong University | | | Limin Ma | The Affiliated Hospital of Nantong University | | | Shujun Zhou | The Affiliated Hospital of Nantong University | | | Wenguang Li | The Affiliated Hospital of Nantong University | |
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| 中文摘要: |
| 摘要 目的：近年来的研究表明Oct4和IL-18的基因异常表达和癌症有关，但Oct4和IL-18的基因多态性在前列腺癌的分子机制仍不明确。本研究目的是探讨Oct4和IL-18的基因多态性在前列腺癌患者，肿瘤大小，分级，TNM分期和患者生存率的表达情况。
方法：评估Oct4和IL-18的基因多态性，易感性在120位前列腺癌患者的表达。对照组为125位随机样本。基因分型采用TaqMan等位基因鉴别试验。采用SPSS进行统计学分析。
结果：研究发现Oct4和IL-18的基因多态性在前列腺癌肿瘤易感性方面无明显关联。Oct4-AA 和IL-18-607 CC基因分型和较高的肿瘤分级 (P=0.03和P = 0.025)和分期 (P=0.04 和P = 0.001)有关。IL-18-137 GG基因分型和较高的肿瘤分级 (P = 0.028) 和分期 (P = 0.008)有关。Oct4-AA 和淋巴结和远处转移有关（(P = 0.02和P = 0.01）。Cox比例风险模型显示肿瘤分期和分级是独立的预后因子，但Oct4和IL-18的基因多态性不是。
结论 Oct4基因可能在前列腺癌风险有较大的影响。Oct4和IL-18的基因多态性的变异可能和较差的前列腺癌预后有关。 |
| 英文摘要: |
| Objective Recent studies have shown abnormal expression of octamer-binding transcription factor 4
(OCT4) and interleukin-18 (IL-18) to be related to cancer. However, the molecular mechanisms by which
the IL-18 and OCT4 gene polymorphisms are associated with prostate cancer remain unclear. In this study,
we aimed to determine whether the presence of IL-18 and OCT4 polymorphisms were associated with size,
grade, tumor, nodes and metastasis (TNM) stage, or survival in patients with prostate cancer.
Methods Polymorphisms in OCT4 and IL-18 genes were evaluated to determine susceptibility to prostate
cancer in 120 patients. A control group consisted of 125 Chinese participants. Genotyping was performed
using TaqMan allelic discrimination assays, and statistical analysis was performed using SPSS.
Results No association was found between OCT4 and IL-18 gene polymorphisms and prostate cancer
susceptibility. For OCT4 AA and IL-18-607 CC genotypes, there was a significant association with higher
tumor grade (P = 0.03 and P = 0.025) and stage (P = 0.04 and P = 0.001). The OCT4 and IL-18-137
GG genotype was correlated with higher tumor grade (P = 0.028) and stage (P = 0.008). Furthermore,
OCT4 AA was significantly more frequent in patients with lymph node metastasis (P = 0.02) and distant
metastasis (P = 0.01). The Cox proportional hazard model showed that tumor grade and stage grouping
were independent prognostic factors but IL-18 and OCT4 polymorphisms were not.
Conclusion The OCT4 gene may have a profound effect on prostate cancer risk. Polymorphism variants
in the IL-18 (IL-18-607 and IL-18-137) and OCT4 genes may be associated with poor prognoses for
individuals with prostate cancer. |
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