| Kan Jiang,Xiaoyu Wu,Baiying Liu,Wenbin Li,Taotao Zhang,Xiangwen Zhang,Changle Ren,Guo Zu. Primary gastric adenosquamous carcinoma: a case report and literature review. Oncol Transl Med, 2019, 5: 188-191. |
| Primary gastric adenosquamous carcinoma: a case report and literature review |
| Received:January 25, 2019 Revised:June 13, 2019 |
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| KeyWord:adenosquamous carcinoma; gastric cancer; treatment |
| Author Name | Affiliation | E-mail | | Kan Jiang | Department of Gastroenterology Surgery, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China | 1394807918@qq.com | | Xiaoyu Wu | Department of Gastroenterology Surgery, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China | | | Baiying Liu | Department of Gastroenterology Surgery, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China | | | Wenbin Li | Department of Gastroenterology Surgery, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China | | | Taotao Zhang | Department of Gastroenterology Surgery, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China | | | Xiangwen Zhang | Department of Gastroenterology Surgery, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China | | | Changle Ren | The Dalian Municipal Central Hospital Affiliated of Dalian Medical University | | | Guo Zu | Department of Gastroenterology Surgery, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China | zushanghai@163.com |
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| Abstract: |
| Primary gastric adenosquamous carcinoma (GASC) is exceedingly rare. It accounts for less than 1% of
all gastric cancers. In this report, we describe our pathological findings along with a review of the literature
to improve our understanding of the disease and reduce misdiagnosis, as well as to provide evidence for
its treatment and prognosis. A 49-year-old male patient was admitted to our hospital (Dalian Municipal
Central Hospital, Dalian, China) with a complaint of epigastric pain that had persisted for half a month.
Physical examination, regular laboratory blood tests, and computed tomography revealed no obvious
abnormalities. Gastroscopy revealed ulcers in the lower part of the stomach, and pathological assessment
revealed adenocarcinoma. Radical gastrectomy was performed, and the folinic acid, fluorouracil, oxaliplatin
(FOLFOX) chemotherapy regimen was administered postoperatively. Pathological assessment of the mass
revealed a protruding tumor measuring 1.5 × 1.5 × 0.7 cm in the lower part of the stomach. The tumor
infiltrated through the full wall of the stomach. This was confirmed by immunohistochemical (IHC) staining
for cytokeratin (CK) (+), villin (-), p63 (++), and high-molecular-weight CK (+++). The patient remains alive
with no recurrence more than seven years after surgery. Primary GASC is a rare malignant neoplasm. The
diagnostic criteria for GASC mainly depend on the clinical, radiographic, and histopathological findings.
Pathological assessment and IHC staining can be utilized to confirm the diagnosis. Radical gastrectomy
plus postoperative chemotherapy containing the FOLFOX regimen is effective for treating GASC and might
contribute to long-term survival |
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