| Kan Jiang,Xiaoyu Wu,Baiying Liu,Wenbin Li,Taotao Zhang,Xiangwen Zhang,Changle Ren,Guo Zu. Primary gastric adenosquamous carcinoma: a case report and literature review. Oncol Transl Med, 2019, 5: 188-191. |
| 原发性胃腺鳞癌：1例病例报告并文献复习 |
| Primary gastric adenosquamous carcinoma: a case report and literature review |
| Received:January 25, 2019 Revised:June 13, 2019 |
| DOI：10.1007/s10330-019-0332-2 |
| 中文关键词: 胃腺鳞癌；胃癌；治疗。 |
| 英文关键词: adenosquamous carcinoma; gastric cancer; treatment |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Kan Jiang | Department of Gastroenterology Surgery, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China | 1394807918@qq.com | | Xiaoyu Wu | Department of Gastroenterology Surgery, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China | | | Baiying Liu | Department of Gastroenterology Surgery, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China | | | Wenbin Li | Department of Gastroenterology Surgery, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China | | | Taotao Zhang | Department of Gastroenterology Surgery, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China | | | Xiangwen Zhang | Department of Gastroenterology Surgery, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China | | | Changle Ren | The Dalian Municipal Central Hospital Affiliated of Dalian Medical University | | | Guo Zu* | Department of Gastroenterology Surgery, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China | zushanghai@163.com |
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| 中文摘要: |
| 目的：原发性胃腺鳞癌非常罕见。它占所有胃癌的不到1 %。在本报告中，我们描述了我们的病理发现，并回顾了文献，以提高我们对该疾病的理解，防止误诊，并为其治疗和预后提供证据。
方法：一名49岁男性患者以上腹疼痛半个月为主诉收入我院治疗。体格检查、常规实验室血液和计算机断层扫描测试显示没有明显的异常。胃镜检查显示胃体下部有溃疡性病灶，病理提示为腺癌。进行了根治性胃切除术，并实施了FOLFOX化疗方案。
结果：肿块病理显示胃体下部有一个1.5 × 1.5 × 0.7 cm的突出肿瘤，浸润整个胃壁，这可以被免疫组织化学( IHC )染色，细胞角蛋白CK (+ )、绒毛蛋白( - )、p63 (+ )、高分子量细胞角蛋白( CK-h) (+++ )所证实。病人在接受手术后七年多没有复发。
结论：原发性胃腺鳞癌是一种罕见的恶性肿瘤。它的诊断标准主要取决于临床、影像学和组织病理学的发现。病理形态学和免疫组化染色可用于确认诊断。根治性胃切除术加FOLFOX方案的术后化疗对治疗原发性胃腺鳞癌有效，并且可能有助于长期生存。 |
| 英文摘要: |
| Primary gastric adenosquamous carcinoma (GASC) is exceedingly rare. It accounts for less than 1% of
all gastric cancers. In this report, we describe our pathological findings along with a review of the literature
to improve our understanding of the disease and reduce misdiagnosis, as well as to provide evidence for
its treatment and prognosis. A 49-year-old male patient was admitted to our hospital (Dalian Municipal
Central Hospital, Dalian, China) with a complaint of epigastric pain that had persisted for half a month.
Physical examination, regular laboratory blood tests, and computed tomography revealed no obvious
abnormalities. Gastroscopy revealed ulcers in the lower part of the stomach, and pathological assessment
revealed adenocarcinoma. Radical gastrectomy was performed, and the folinic acid, fluorouracil, oxaliplatin
(FOLFOX) chemotherapy regimen was administered postoperatively. Pathological assessment of the mass
revealed a protruding tumor measuring 1.5 × 1.5 × 0.7 cm in the lower part of the stomach. The tumor
infiltrated through the full wall of the stomach. This was confirmed by immunohistochemical (IHC) staining
for cytokeratin (CK) (+), villin (-), p63 (++), and high-molecular-weight CK (+++). The patient remains alive
with no recurrence more than seven years after surgery. Primary GASC is a rare malignant neoplasm. The
diagnostic criteria for GASC mainly depend on the clinical, radiographic, and histopathological findings.
Pathological assessment and IHC staining can be utilized to confirm the diagnosis. Radical gastrectomy
plus postoperative chemotherapy containing the FOLFOX regimen is effective for treating GASC and might
contribute to long-term survival |
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