| Weidong Wu,Xiaozhen Zhan,Kezhen Wang,Chengzhi Cui,Peiyu Cong. Olfactory schwannoma: a case report. Oncol Transl Med, 2018, 4: 259-262. |
| 嗅神经鞘瘤一例报告 |
| Olfactory schwannoma: a case report |
| Received:November 09, 2018 Revised:January 04, 2019 |
| DOI：10.1007/s10330-018-0316-6 |
| 中文关键词: 嗅神经鞘瘤、前颅窝神经鞘瘤、神经鞘瘤、诊断、治疗 |
| 英文关键词: olfactory schwannoma; anterior skull base schwannoma; schwannoma; diagnosis; treatment |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Weidong Wu | Dalian Municipal Central Hospital | w853289125@163.com | | Xiaozhen Zhan | Dalian Municipal Central Hospital | | | Kezhen Wang | Dalian Municipal Central Hospital | | | Chengzhi Cui | Dalian Municipal Central Hospital | | | Peiyu Cong* | Dalian Municipal Central Hospital | congpydalian@163.com |
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| 中文摘要: |
| 目的 颅内神经鞘瘤常见于第VIII对颅神经，其次是第V和第VII对颅神经。发生在嗅神经的神经鞘瘤非常罕见。我们在这报告一例嗅神经鞘瘤，并对相关文献进行复习，以提高对嗅神经鞘瘤的诊断和治疗。
方法 我们在这里报告一例嗅神经鞘瘤是来自51岁中国男性患者，该患者主要临床症状为头晕，无其它不适。
结果 磁共振成像（MRI）显示肿物位于右侧前颅窝底邻近筛板和蝶骨平台。病变通过筛板进入鼻腔。初步诊断考虑为嗅沟脑膜瘤。我们进行了开颅手术切除，肿瘤完全切除同时采取重建颅底。手术过程中无手术并发症发生，术后患者恢复良好。术后组织病理学诊断为神经鞘瘤。
结论 嗅神经鞘瘤极为罕见，并且临床特征与嗅鞘细胞瘤（OECT）非常相似，免疫组织化学染色Leu7（CD57）可用于鉴别这两种肿瘤。虽然嗅神经鞘瘤的标准治疗方式仍未明确，复习相关文献报道，大多数患者通过有效的手术切除后预后较好。 |
| 英文摘要: |
| Objective?Intracranial schwannomas are frequently located in the VIII cranial nerve, followed by the V and VII cranial nerves, but are quite rare in the olfactory cranial nerves. Here, we report a case of an olfactory schwannoma and review the literature to improve the diagnosis and treatment of olfactory schwannoma.
Methods?We report a case of olfactory schwannoma in a 51-year-old Chinese man who experienced dizziness and no other symptoms.
Results?Magnetic resonance imaging (MRI) showed a neoplastic mass located on the anterior cranial base to the right of the midline and near the cribriform plate and sphenoidal plane. The lesion travelled through the cribriform plate into the nasal cavity. This mass was initially thought to be an olfactory groove meningioma. We performed a craniotomy for surgical excision, and the tumor was completely resected, and the skull base was reconstructed at the same time. There were no complications during surgery, and the patient recovered well. The histopathological diagnosis was a schwannoma.
Conclusion?Olfactory schwannomas are extremely rare and similar to olfactory ensheating cell tumors, and the immunohistochemical staining of leukocyte antigen 7 (Leu7/CD57) can be used to identify them. Although the standard treatment of olfactory schwannoma remains unclear, in all reports, most patients can have excellent prognosis after an effective surgical resection.
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